Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis
Abstract Objective Previous studies have proposed that food intakes are associated with the risk of urolithiasis. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal effects of different food intakes on urolithiasis. Methods Independent genetic variants associat...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Human Genomics |
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| Online Access: | https://doi.org/10.1186/s40246-023-00523-2 |
| _version_ | 1797557831252049920 |
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| author | Yiwei Lin Cheng Zhou Yuqing Wu Hong Chen Liping Xie Xiangyi Zheng |
| author_facet | Yiwei Lin Cheng Zhou Yuqing Wu Hong Chen Liping Xie Xiangyi Zheng |
| author_sort | Yiwei Lin |
| collection | DOAJ |
| description | Abstract Objective Previous studies have proposed that food intakes are associated with the risk of urolithiasis. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal effects of different food intakes on urolithiasis. Methods Independent genetic variants associated with different food intakes at a genome-wide significant level were selected from summary-level statistics of genome-wide association studies from the UK Biobank. The association of these instrumental variables with urolithiasis was studied in a cohort from FinnGen Consortium. Results Among the 15 studied food intake exposures, tea intake (odds ratio [OR] = 0.433, 95% confidence interval [CI] = 0.281–0.667, p value = 1.470 × 10–4) and fresh fruit intake (OR = 0.358, 95% CI = 0.185–0.694, p value = 0.002) were found to significantly reduce the risk of the calculus of kidney and ureter. The association remained consistent in the sensitivity analyses. After adjusting for the effects of vitamin D and vitamin C, fresh fruit intake remained the reverse causal association with the calculus of kidney and ureter. Conclusions Genetically proxied fresh fruit intake is causally associated with a reduced risk of the calculus of kidney and ureter. |
| first_indexed | 2024-03-10T17:21:49Z |
| format | Article |
| id | doaj.art-c131383fcf0347d0b69769769809d3f7 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-03-10T17:21:49Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-c131383fcf0347d0b69769769809d3f72023-11-20T10:18:52ZengBMCHuman Genomics1479-73642023-10-011711810.1186/s40246-023-00523-2Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasisYiwei Lin0Cheng Zhou1Yuqing Wu2Hong Chen3Liping Xie4Xiangyi Zheng5Department of Urology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Urology, The First Affiliated Hospital, Zhejiang University School of MedicineAbstract Objective Previous studies have proposed that food intakes are associated with the risk of urolithiasis. Here, we conducted a two-sample Mendelian randomization (MR) study to evaluate the causal effects of different food intakes on urolithiasis. Methods Independent genetic variants associated with different food intakes at a genome-wide significant level were selected from summary-level statistics of genome-wide association studies from the UK Biobank. The association of these instrumental variables with urolithiasis was studied in a cohort from FinnGen Consortium. Results Among the 15 studied food intake exposures, tea intake (odds ratio [OR] = 0.433, 95% confidence interval [CI] = 0.281–0.667, p value = 1.470 × 10–4) and fresh fruit intake (OR = 0.358, 95% CI = 0.185–0.694, p value = 0.002) were found to significantly reduce the risk of the calculus of kidney and ureter. The association remained consistent in the sensitivity analyses. After adjusting for the effects of vitamin D and vitamin C, fresh fruit intake remained the reverse causal association with the calculus of kidney and ureter. Conclusions Genetically proxied fresh fruit intake is causally associated with a reduced risk of the calculus of kidney and ureter.https://doi.org/10.1186/s40246-023-00523-2Food intakeUrolithiasisMendelian randomizationKidney stone disease |
| spellingShingle | Yiwei Lin Cheng Zhou Yuqing Wu Hong Chen Liping Xie Xiangyi Zheng Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis Human Genomics Food intake Urolithiasis Mendelian randomization Kidney stone disease |
| title | Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis |
| title_full | Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis |
| title_fullStr | Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis |
| title_full_unstemmed | Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis |
| title_short | Mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis |
| title_sort | mendelian randomization analysis reveals fresh fruit intake as a protective factor for urolithiasis |
| topic | Food intake Urolithiasis Mendelian randomization Kidney stone disease |
| url | https://doi.org/10.1186/s40246-023-00523-2 |
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