Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review
Background: With the rapidly-increased HIV epidemic among men who have sex with men worldwide, the effectiveness of voluntary medical male circumcision as the tool of HIV prevention still remains undetermined. Purpose: In the current study, we conducted a systematic review and meta-analysis to asses...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2019-08-01
|
| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/2050312119869110 |
| _version_ | 1818847102165319680 |
|---|---|
| author | Chen Zhang Han-Zhu Qian Yu Liu Sten H Vermund |
| author_facet | Chen Zhang Han-Zhu Qian Yu Liu Sten H Vermund |
| author_sort | Chen Zhang |
| collection | DOAJ |
| description | Background: With the rapidly-increased HIV epidemic among men who have sex with men worldwide, the effectiveness of voluntary medical male circumcision as the tool of HIV prevention still remains undetermined. Purpose: In the current study, we conducted a systematic review and meta-analysis to assess the association between voluntary medical male circumcision and HIV risk among men who have sex with men. Methods and Conclusion: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, we conducted a comprehensive literature search through multiple databases. A total of 37 articles/abstracts were included in the analysis. We employed random-effects models and subgroup analyses based upon key study characteristics derived from empirical studies. A total of 117,293 men who have sex with men were included in the meta-analysis, and no randomized control trials have been identified. The odds of being HIV positive were 7% lower among men who have sex with men who were circumcised than among men who have sex with men who were uncircumcised (adjusted odds ratio, 0.93; 95% confidence interval, 0.88–0.99). The evidence for the potential protective effect of voluntary medical male circumcision was stronger among men who have sex with men in Asia and Africa (adjusted odds ratio, 0.62; 95% confidence interval, 0.53–0.73). Our meta-analyses may suggest a protective effect of voluntary medical male circumcision against HIV infection among men who have sex with men, especially in settings like Asia/Africa. |
| first_indexed | 2024-12-19T05:56:06Z |
| format | Article |
| id | doaj.art-c1324ef2d32c4e52aa7b569007ef956c |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-12-19T05:56:06Z |
| publishDate | 2019-08-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-c1324ef2d32c4e52aa7b569007ef956c2022-12-21T20:33:27ZengSAGE PublishingSAGE Open Medicine2050-31212019-08-01710.1177/2050312119869110Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic reviewChen Zhang0Han-Zhu Qian1Yu Liu2Sten H Vermund3School of Nursing, University of Rochester Medical Center, Rochester, NY, USAYale School of Public Health, Yale University, New Haven, CT, USADivision of Epidemiology, Department of Public Health Science, University of Rochester Medical Center, Rochester, NY, USAYale School of Public Health, Yale University, New Haven, CT, USABackground: With the rapidly-increased HIV epidemic among men who have sex with men worldwide, the effectiveness of voluntary medical male circumcision as the tool of HIV prevention still remains undetermined. Purpose: In the current study, we conducted a systematic review and meta-analysis to assess the association between voluntary medical male circumcision and HIV risk among men who have sex with men. Methods and Conclusion: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guideline, we conducted a comprehensive literature search through multiple databases. A total of 37 articles/abstracts were included in the analysis. We employed random-effects models and subgroup analyses based upon key study characteristics derived from empirical studies. A total of 117,293 men who have sex with men were included in the meta-analysis, and no randomized control trials have been identified. The odds of being HIV positive were 7% lower among men who have sex with men who were circumcised than among men who have sex with men who were uncircumcised (adjusted odds ratio, 0.93; 95% confidence interval, 0.88–0.99). The evidence for the potential protective effect of voluntary medical male circumcision was stronger among men who have sex with men in Asia and Africa (adjusted odds ratio, 0.62; 95% confidence interval, 0.53–0.73). Our meta-analyses may suggest a protective effect of voluntary medical male circumcision against HIV infection among men who have sex with men, especially in settings like Asia/Africa.https://doi.org/10.1177/2050312119869110 |
| spellingShingle | Chen Zhang Han-Zhu Qian Yu Liu Sten H Vermund Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review SAGE Open Medicine |
| title | Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review |
| title_full | Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review |
| title_fullStr | Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review |
| title_full_unstemmed | Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review |
| title_short | Voluntary medical male circumcision and HIV infection among men who have sex with men: Implications from a systematic review |
| title_sort | voluntary medical male circumcision and hiv infection among men who have sex with men implications from a systematic review |
| url | https://doi.org/10.1177/2050312119869110 |
| work_keys_str_mv | AT chenzhang voluntarymedicalmalecircumcisionandhivinfectionamongmenwhohavesexwithmenimplicationsfromasystematicreview AT hanzhuqian voluntarymedicalmalecircumcisionandhivinfectionamongmenwhohavesexwithmenimplicationsfromasystematicreview AT yuliu voluntarymedicalmalecircumcisionandhivinfectionamongmenwhohavesexwithmenimplicationsfromasystematicreview AT stenhvermund voluntarymedicalmalecircumcisionandhivinfectionamongmenwhohavesexwithmenimplicationsfromasystematicreview |