| Summary: | Tooth decay has occurred due to the numerous microorganisms in the mouth such as Streptococcus and Lactobacilli bacteria that can produce acid. Commercial antiplatelet agents are predominantly antibacterial compounds, but these compounds can disrupt oral bacterial flora and induce and enhance the growth of opportunistic pathogens, including Candida albicans. Nowadays, bacterial therapy is a replacement therapy for microorganisms. One of the methods of bacterial therapy is the use of probiotic bacteria. So far, many studies have been done on the effect of probiotic-containing food products on the microbial factors of tooth decay. Therefore, this study aimed to investigate the effect of probiotics on dental caries. The search queries were from ISI, PubMed, Scopus, Science Direct, magiran, SID databases. Key words were probiotic, dental caries, bacterial caries, tooth decay, laboratory and clinical studies. Finally, the selected articles were used for the review table. The results of the review of studies showed that probiotic strains are able to control bacterial agents that cause dental caries.
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