Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article
Sintayehu Mekonnen,1 Hawi Farris2 1Department of Internal Medicine, All Africa Leprosy, Tuberculosis and Rehabilitation Training Center, Addis Ababa, Ethiopia; 2Department of Radiology, Addis Ababa University College of Health Science, Addis Ababa, EthiopiaCorrespondence: Sintayehu Mekonnen, Email s...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-03-01
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| Series: | Biologics: Targets & Therapy |
| Subjects: | |
| Online Access: | https://www.dovepress.com/why-and-how-should-ethiopia-establish-a-stem-cell-transplant-service-a-peer-reviewed-fulltext-article-BTT |
| _version_ | 1797866252837847040 |
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| author | Mekonnen S Farris H |
| author_facet | Mekonnen S Farris H |
| author_sort | Mekonnen S |
| collection | DOAJ |
| description | Sintayehu Mekonnen,1 Hawi Farris2 1Department of Internal Medicine, All Africa Leprosy, Tuberculosis and Rehabilitation Training Center, Addis Ababa, Ethiopia; 2Department of Radiology, Addis Ababa University College of Health Science, Addis Ababa, EthiopiaCorrespondence: Sintayehu Mekonnen, Email sintu04mekonnen@gmail.comAbstract: Ethiopia is attempting to reduce cancer-related morbidity and mortality through a strategic national cancer control plan but according to Globocan 2020, hematologic malignancies particularly leukemia and non-Hodgkin’s lymphoma rank among the top five leading causes of new cancer incidence and cause of death among all age groups in both sexes. Hematopoietic stem-cell transplantation (HSCT) is an advanced treatment modality that makes the only effective treatment for cancer and non-cancer-related hematologic diseases unresponsive to conventional therapy. Patients who need stem cell transplants must travel to abroad countries to get the treatment. Meanwhile, the Ethiopian National Specialty and Subspecialty Roadmap sets the goal of establishing HSCT centers in 2020– 2029 GC, yet leaders and planners must start taking steps to put the setup in place. Setting up an HSCT facility is challenging for developing countries due to the high costs, limited infrastructure, and need for intensive medical staff training; however, several nations have been able to start successful stem cell transplant programs. This review summarizes the basic steps and requirements of the program in light of guidelines recommendations and lessons learned from other developing countries. It also highlights possible cost-effective opportunities, bottlenecks, and areas that will require work and investment to make the objective reality in Ethiopia. Provides key information to assist administrators and policymakers to set priorities in planning and making informed decisions to establish and maintain the service.Keywords: Ethiopia, cancer, hematopoietic stem-cell transplantation, hematologic malignancy |
| first_indexed | 2024-04-09T23:21:05Z |
| format | Article |
| id | doaj.art-c132ccc60a7b4d8f93cf7f123214a842 |
| institution | Directory Open Access Journal |
| issn | 1177-5491 |
| language | English |
| last_indexed | 2024-04-09T23:21:05Z |
| publishDate | 2023-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Biologics: Targets & Therapy |
| spelling | doaj.art-c132ccc60a7b4d8f93cf7f123214a8422023-03-21T18:11:20ZengDove Medical PressBiologics: Targets & Therapy1177-54912023-03-01Volume 17334082410Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review ArticleMekonnen SFarris HSintayehu Mekonnen,1 Hawi Farris2 1Department of Internal Medicine, All Africa Leprosy, Tuberculosis and Rehabilitation Training Center, Addis Ababa, Ethiopia; 2Department of Radiology, Addis Ababa University College of Health Science, Addis Ababa, EthiopiaCorrespondence: Sintayehu Mekonnen, Email sintu04mekonnen@gmail.comAbstract: Ethiopia is attempting to reduce cancer-related morbidity and mortality through a strategic national cancer control plan but according to Globocan 2020, hematologic malignancies particularly leukemia and non-Hodgkin’s lymphoma rank among the top five leading causes of new cancer incidence and cause of death among all age groups in both sexes. Hematopoietic stem-cell transplantation (HSCT) is an advanced treatment modality that makes the only effective treatment for cancer and non-cancer-related hematologic diseases unresponsive to conventional therapy. Patients who need stem cell transplants must travel to abroad countries to get the treatment. Meanwhile, the Ethiopian National Specialty and Subspecialty Roadmap sets the goal of establishing HSCT centers in 2020– 2029 GC, yet leaders and planners must start taking steps to put the setup in place. Setting up an HSCT facility is challenging for developing countries due to the high costs, limited infrastructure, and need for intensive medical staff training; however, several nations have been able to start successful stem cell transplant programs. This review summarizes the basic steps and requirements of the program in light of guidelines recommendations and lessons learned from other developing countries. It also highlights possible cost-effective opportunities, bottlenecks, and areas that will require work and investment to make the objective reality in Ethiopia. Provides key information to assist administrators and policymakers to set priorities in planning and making informed decisions to establish and maintain the service.Keywords: Ethiopia, cancer, hematopoietic stem-cell transplantation, hematologic malignancyhttps://www.dovepress.com/why-and-how-should-ethiopia-establish-a-stem-cell-transplant-service-a-peer-reviewed-fulltext-article-BTTethiopiacancerhematopoietic stem-cell transplantationhematologic malignancy |
| spellingShingle | Mekonnen S Farris H Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article Biologics: Targets & Therapy ethiopia cancer hematopoietic stem-cell transplantation hematologic malignancy |
| title | Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article |
| title_full | Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article |
| title_fullStr | Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article |
| title_full_unstemmed | Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article |
| title_short | Why and How Should Ethiopia Establish a Stem Cell Transplant Service? A Review Article |
| title_sort | why and how should ethiopia establish a stem cell transplant service a review article |
| topic | ethiopia cancer hematopoietic stem-cell transplantation hematologic malignancy |
| url | https://www.dovepress.com/why-and-how-should-ethiopia-establish-a-stem-cell-transplant-service-a-peer-reviewed-fulltext-article-BTT |
| work_keys_str_mv | AT mekonnens whyandhowshouldethiopiaestablishastemcelltransplantserviceareviewarticle AT farrish whyandhowshouldethiopiaestablishastemcelltransplantserviceareviewarticle |