The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints
Among the proteins of the human body, collagen accounts for at least 25–45% collagen; it is an essential structural component of skeletal tissues, connective tissue of internal organs (heart, intestines, lungs, liver, kidneys), as well as blood vessels. The variety of types of collagen is due to the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Remedium Group LLC
2022-08-01
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| Series: | Медицинский совет |
| Subjects: | |
| Online Access: | https://www.med-sovet.pro/jour/article/view/7032 |
| _version_ | 1797842263053697024 |
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| author | I. S. Dydykina P. S. Kovalenko A. A. Kovalenko A. V. Aboleshina |
| author_facet | I. S. Dydykina P. S. Kovalenko A. A. Kovalenko A. V. Aboleshina |
| author_sort | I. S. Dydykina |
| collection | DOAJ |
| description | Among the proteins of the human body, collagen accounts for at least 25–45% collagen; it is an essential structural component of skeletal tissues, connective tissue of internal organs (heart, intestines, lungs, liver, kidneys), as well as blood vessels. The variety of types of collagen is due to their role and function. The article presents information about the structure and synthesis of collagen, a high concentration of glycine, proline and hydroxyproline in the alpha chains of the collagen helix. Attention is drawn to the fact that cross-links and orientation of collagen fibers in the direction of the vector of external forces and loads provide protection to tissues and organs. The clinical significance of type II collagen is considered on the example of the cartilaginous tissue of the joints and tendons. It is emphasized that an imbalance in the structure of nutrition, genetic mutations, dysfunction of the endocrine and immune systems, especially in old age, are associated with the occurrence of one of the most common joint diseases – osteoarthritis (ОА). It has been established that the degradation or reduction of type II collagen in the cartilage matrix is accompanied by the progression of this disease. Due to the increasing prevalence of OA, signs of metabolic disorders and post-traumatic joint injuries, there is a growing interest in non-pharmacological and pharmacological interventions for the prevention and treatment of osteoarthritis. In recent years, convincing evidence has emerged of the successful use of drugs (biologically active food supplements) of collagen in osteoarthritis. The article presents the results of experimental and clinical studies, meta-analysis and systematic review, confirming the possibility of using these drugs (products) as part of the complex treatment of OA. The possibility of using compositions based on undenatured (native) collagen type II, with the inclusion of ascorbic acid, vitamin D, methylsulfonylmethane and boswellic acids promotes the synergy of these substances, slows down the rate of cartilage destruction, reduces the manifestation of pain and inflammation in the joints, improves functional joint and spinal conditions, promotes the synthesis of endogenous collagen. |
| first_indexed | 2024-04-09T16:45:05Z |
| format | Article |
| id | doaj.art-c133963499cd4b0da75000724bf6e07f |
| institution | Directory Open Access Journal |
| issn | 2079-701X 2658-5790 |
| language | Russian |
| last_indexed | 2024-04-09T16:45:05Z |
| publishDate | 2022-08-01 |
| publisher | Remedium Group LLC |
| record_format | Article |
| series | Медицинский совет |
| spelling | doaj.art-c133963499cd4b0da75000724bf6e07f2023-04-23T06:56:32ZrusRemedium Group LLCМедицинский совет2079-701X2658-57902022-08-0101414515310.21518/2079-701X-2022-16-14-145-1536294The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the jointsI. S. Dydykina0P. S. Kovalenko1A. A. Kovalenko2A. V. Aboleshina3Nasonova Research Institute of RheumatologyNasonova Research Institute of RheumatologySechenov First Moscow State Medical University (Sechenov University)Nasonova Research Institute of RheumatologyAmong the proteins of the human body, collagen accounts for at least 25–45% collagen; it is an essential structural component of skeletal tissues, connective tissue of internal organs (heart, intestines, lungs, liver, kidneys), as well as blood vessels. The variety of types of collagen is due to their role and function. The article presents information about the structure and synthesis of collagen, a high concentration of glycine, proline and hydroxyproline in the alpha chains of the collagen helix. Attention is drawn to the fact that cross-links and orientation of collagen fibers in the direction of the vector of external forces and loads provide protection to tissues and organs. The clinical significance of type II collagen is considered on the example of the cartilaginous tissue of the joints and tendons. It is emphasized that an imbalance in the structure of nutrition, genetic mutations, dysfunction of the endocrine and immune systems, especially in old age, are associated with the occurrence of one of the most common joint diseases – osteoarthritis (ОА). It has been established that the degradation or reduction of type II collagen in the cartilage matrix is accompanied by the progression of this disease. Due to the increasing prevalence of OA, signs of metabolic disorders and post-traumatic joint injuries, there is a growing interest in non-pharmacological and pharmacological interventions for the prevention and treatment of osteoarthritis. In recent years, convincing evidence has emerged of the successful use of drugs (biologically active food supplements) of collagen in osteoarthritis. The article presents the results of experimental and clinical studies, meta-analysis and systematic review, confirming the possibility of using these drugs (products) as part of the complex treatment of OA. The possibility of using compositions based on undenatured (native) collagen type II, with the inclusion of ascorbic acid, vitamin D, methylsulfonylmethane and boswellic acids promotes the synergy of these substances, slows down the rate of cartilage destruction, reduces the manifestation of pain and inflammation in the joints, improves functional joint and spinal conditions, promotes the synthesis of endogenous collagen.https://www.med-sovet.pro/jour/article/view/7032collagen structure and functiontype ii collagenstructure of hyaline cartilagetype ii collagen products for the treatment of osteoarthritisundenatured type ii collagen in the complex treatment of osteoarthritis |
| spellingShingle | I. S. Dydykina P. S. Kovalenko A. A. Kovalenko A. V. Aboleshina The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints Медицинский совет collagen structure and function type ii collagen structure of hyaline cartilage type ii collagen products for the treatment of osteoarthritis undenatured type ii collagen in the complex treatment of osteoarthritis |
| title | The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints |
| title_full | The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints |
| title_fullStr | The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints |
| title_full_unstemmed | The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints |
| title_short | The value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints |
| title_sort | value of undenatured collagen for the normalization of the function of the cartilaginous tissue of the joints |
| topic | collagen structure and function type ii collagen structure of hyaline cartilage type ii collagen products for the treatment of osteoarthritis undenatured type ii collagen in the complex treatment of osteoarthritis |
| url | https://www.med-sovet.pro/jour/article/view/7032 |
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