Thermofluidic chip containing virtual thermal wells
The authors describe a thermofluidic chip on which microscale islands of controlled temperature are formed within an open fluidic environment. The chip forms part of the authors’ technology for thermally controlled DNA synthesis, whereby the site-specific temperature control enables site-specific ad...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-02-01
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| Series: | Engineering Biology |
| Subjects: | |
| Online Access: | https://digital-library.theiet.org/content/journals/10.1049/enb.2018.5010 |
| _version_ | 1818426051979640832 |
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| author | Andrew J. Ferguson Matthew J. Hayes Blair C. Kirkpatrick Yen-chun Lin Vijay Narayan Albert Prak Albert Prak |
| author_facet | Andrew J. Ferguson Matthew J. Hayes Blair C. Kirkpatrick Yen-chun Lin Vijay Narayan Albert Prak Albert Prak |
| author_sort | Andrew J. Ferguson |
| collection | DOAJ |
| description | The authors describe a thermofluidic chip on which microscale islands of controlled temperature are formed within an open fluidic environment. The chip forms part of the authors’ technology for thermally controlled DNA synthesis, whereby the site-specific temperature control enables site-specific addressability of chemical reactions, for example, related to the phosphoramidite cycle. Here, the authors discuss the principle of the chip, supporting the thermal well concept by means of simulations as well as by showing a prototype thermal array device. |
| first_indexed | 2024-12-14T14:23:42Z |
| format | Article |
| id | doaj.art-c133d3bd47da4d4080cc3a40b8610c92 |
| institution | Directory Open Access Journal |
| issn | 2398-6182 |
| language | English |
| last_indexed | 2024-12-14T14:23:42Z |
| publishDate | 2019-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Engineering Biology |
| spelling | doaj.art-c133d3bd47da4d4080cc3a40b8610c922022-12-21T22:58:00ZengWileyEngineering Biology2398-61822019-02-0110.1049/enb.2018.5010ENB.2018.5010Thermofluidic chip containing virtual thermal wellsAndrew J. Ferguson0Matthew J. Hayes1Blair C. Kirkpatrick2Yen-chun Lin3Vijay Narayan4Albert Prak5Albert Prak6Evonetix LtdEvonetix LtdEvonetix LtdEvonetix LtdEvonetix LtdLioniX International BVLioniX International BVThe authors describe a thermofluidic chip on which microscale islands of controlled temperature are formed within an open fluidic environment. The chip forms part of the authors’ technology for thermally controlled DNA synthesis, whereby the site-specific temperature control enables site-specific addressability of chemical reactions, for example, related to the phosphoramidite cycle. Here, the authors discuss the principle of the chip, supporting the thermal well concept by means of simulations as well as by showing a prototype thermal array device.https://digital-library.theiet.org/content/journals/10.1049/enb.2018.5010microfluidicstemperature controldnamolecular biophysicsthermofluidic chipvirtual thermal wellsmicroscale islandscontrolled temperatureopen fluidic environmentauthorsthermally controlled dna synthesissite-specific temperature controlsite-specific addressabilitythermal well conceptprototype thermal array device |
| spellingShingle | Andrew J. Ferguson Matthew J. Hayes Blair C. Kirkpatrick Yen-chun Lin Vijay Narayan Albert Prak Albert Prak Thermofluidic chip containing virtual thermal wells Engineering Biology microfluidics temperature control dna molecular biophysics thermofluidic chip virtual thermal wells microscale islands controlled temperature open fluidic environment authors thermally controlled dna synthesis site-specific temperature control site-specific addressability thermal well concept prototype thermal array device |
| title | Thermofluidic chip containing virtual thermal wells |
| title_full | Thermofluidic chip containing virtual thermal wells |
| title_fullStr | Thermofluidic chip containing virtual thermal wells |
| title_full_unstemmed | Thermofluidic chip containing virtual thermal wells |
| title_short | Thermofluidic chip containing virtual thermal wells |
| title_sort | thermofluidic chip containing virtual thermal wells |
| topic | microfluidics temperature control dna molecular biophysics thermofluidic chip virtual thermal wells microscale islands controlled temperature open fluidic environment authors thermally controlled dna synthesis site-specific temperature control site-specific addressability thermal well concept prototype thermal array device |
| url | https://digital-library.theiet.org/content/journals/10.1049/enb.2018.5010 |
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