MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases
Mitochondria are the key organelles that supply cellular energy. As the most active organ in the body, the energy required to maintain the mechanical function of the heart requires a high quantity of high-quality mitochondria in cardiomyocytes. MicroRNAs (miRNAs) are single-stranded noncoding RNAs,...
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| Format: | Article |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.663322/full |
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| author | Guang-Qiong Zhang Guang-Qiong Zhang Guang-Qiong Zhang Sheng-Quan Wang Sheng-Quan Wang Sheng-Quan Wang Yan Chen Yan Chen Yan Chen Ling-Yun Fu Ling-Yun Fu Ling-Yun Fu Yi-Ni Xu Yi-Ni Xu Yi-Ni Xu Ling Li Ling Li Ling Li Ling Tao Ling Tao Ling Tao Xiang-Chun Shen Xiang-Chun Shen Xiang-Chun Shen |
| author_facet | Guang-Qiong Zhang Guang-Qiong Zhang Guang-Qiong Zhang Sheng-Quan Wang Sheng-Quan Wang Sheng-Quan Wang Yan Chen Yan Chen Yan Chen Ling-Yun Fu Ling-Yun Fu Ling-Yun Fu Yi-Ni Xu Yi-Ni Xu Yi-Ni Xu Ling Li Ling Li Ling Li Ling Tao Ling Tao Ling Tao Xiang-Chun Shen Xiang-Chun Shen Xiang-Chun Shen |
| author_sort | Guang-Qiong Zhang |
| collection | DOAJ |
| description | Mitochondria are the key organelles that supply cellular energy. As the most active organ in the body, the energy required to maintain the mechanical function of the heart requires a high quantity of high-quality mitochondria in cardiomyocytes. MicroRNAs (miRNAs) are single-stranded noncoding RNAs, approximately 22 nt in length, which play key roles in mediating post-transcriptional gene silencing. Numerous studies have confirmed that miRNAs can participate in the occurrence and development of cardiac diseases by regulating mitochondrial function-related genes and signaling pathways. Therefore, elucidating the crosstalk that occurs between miRNAs and mitochondria is important for the prevention and treatment of cardiac diseases. In this review, we discuss the biogenesis of miRNAs, the miRNA-mediated regulation of major genes involved in the maintenance of mitochondrial function, and the effects of miRNAs on mitochondrial function in cardiac diseases in order to provide a theoretical basis for the clinical prevention and treatment of cardiac disease and the development of new drugs. |
| first_indexed | 2024-12-17T00:30:38Z |
| format | Article |
| id | doaj.art-c13598f9f1054d95a8c5e6e50ffe92fb |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-17T00:30:38Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-c13598f9f1054d95a8c5e6e50ffe92fb2022-12-21T22:10:20ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-05-011210.3389/fphar.2021.663322663322MicroRNAs Regulating Mitochondrial Function in Cardiac DiseasesGuang-Qiong Zhang0Guang-Qiong Zhang1Guang-Qiong Zhang2Sheng-Quan Wang3Sheng-Quan Wang4Sheng-Quan Wang5Yan Chen6Yan Chen7Yan Chen8Ling-Yun Fu9Ling-Yun Fu10Ling-Yun Fu11Yi-Ni Xu12Yi-Ni Xu13Yi-Ni Xu14Ling Li15Ling Li16Ling Li17Ling Tao18Ling Tao19Ling Tao20Xiang-Chun Shen21Xiang-Chun Shen22Xiang-Chun Shen23The State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe State Key Laboratory of Functions and Applications of Medicinal Plants, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe High Efficacy Application of Natural Medicinal Resources Engineering Center of Guizhou Province, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaThe Key Laboratory of Optimal Utilization of Natural Medicine Resources, School of Pharmaceutical Sciences, Guizhou Medical University, Guizhou, ChinaMitochondria are the key organelles that supply cellular energy. As the most active organ in the body, the energy required to maintain the mechanical function of the heart requires a high quantity of high-quality mitochondria in cardiomyocytes. MicroRNAs (miRNAs) are single-stranded noncoding RNAs, approximately 22 nt in length, which play key roles in mediating post-transcriptional gene silencing. Numerous studies have confirmed that miRNAs can participate in the occurrence and development of cardiac diseases by regulating mitochondrial function-related genes and signaling pathways. Therefore, elucidating the crosstalk that occurs between miRNAs and mitochondria is important for the prevention and treatment of cardiac diseases. In this review, we discuss the biogenesis of miRNAs, the miRNA-mediated regulation of major genes involved in the maintenance of mitochondrial function, and the effects of miRNAs on mitochondrial function in cardiac diseases in order to provide a theoretical basis for the clinical prevention and treatment of cardiac disease and the development of new drugs.https://www.frontiersin.org/articles/10.3389/fphar.2021.663322/fullmicroRNAsmitochondrial functioncardiac diseasecardiac apoptosiscardiac hypertrophydiabetic cardiomyopathy |
| spellingShingle | Guang-Qiong Zhang Guang-Qiong Zhang Guang-Qiong Zhang Sheng-Quan Wang Sheng-Quan Wang Sheng-Quan Wang Yan Chen Yan Chen Yan Chen Ling-Yun Fu Ling-Yun Fu Ling-Yun Fu Yi-Ni Xu Yi-Ni Xu Yi-Ni Xu Ling Li Ling Li Ling Li Ling Tao Ling Tao Ling Tao Xiang-Chun Shen Xiang-Chun Shen Xiang-Chun Shen MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases Frontiers in Pharmacology microRNAs mitochondrial function cardiac disease cardiac apoptosis cardiac hypertrophy diabetic cardiomyopathy |
| title | MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases |
| title_full | MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases |
| title_fullStr | MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases |
| title_full_unstemmed | MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases |
| title_short | MicroRNAs Regulating Mitochondrial Function in Cardiac Diseases |
| title_sort | micrornas regulating mitochondrial function in cardiac diseases |
| topic | microRNAs mitochondrial function cardiac disease cardiac apoptosis cardiac hypertrophy diabetic cardiomyopathy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.663322/full |
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