Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish

Exercise, programmed cell death and exhaustion of cardiomyocyte proliferation in aging zebrafish

Exercise may ameliorate the eventual heart failure inherent in human aging. In this study, we use zebrafish to understand how aging and exercise affect cardiomyocyte turnover and myocardial remodelling. We show that cardiomyocyte proliferation remains constant throughout life but that onset of fibro...

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Bibliographic Details
Main Authors: Lindsay B. Murphy, Adrian Santos-Ledo, Tamilvendhan Dhanaseelan, Lorraine Eley, David Burns, Deborah J. Henderson, Bill Chaudhry
Format: Article
Language:English
Published: The Company of Biologists 2021-07-01
Series:Disease Models & Mechanisms
Subjects:
cardiomyocyte turnover
fibrosis
aging
zebrafish heart
exercise
Online Access:http://dmm.biologists.org/content/14/7/dmm049013

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