Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix
Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Coho...
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| Format: | Article |
| Language: | English |
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Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
2019-01-01
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| Series: | Scripta Medica |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2019/2490-33291902069D.pdf |
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| author | Dabeski Drage Dabeski Ana Antovska Vesna Trajanova Milka Todorovska Irena Sima Aneta |
| author_facet | Dabeski Drage Dabeski Ana Antovska Vesna Trajanova Milka Todorovska Irena Sima Aneta |
| author_sort | Dabeski Drage |
| collection | DOAJ |
| description | Background: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation. Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%. Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected. |
| first_indexed | 2024-12-11T14:26:53Z |
| format | Article |
| id | doaj.art-c137403f9d074c778cc5138e49e8b3d6 |
| institution | Directory Open Access Journal |
| issn | 2490-3329 2303-7954 |
| language | English |
| last_indexed | 2024-12-11T14:26:53Z |
| publishDate | 2019-01-01 |
| publisher | Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine |
| record_format | Article |
| series | Scripta Medica |
| spelling | doaj.art-c137403f9d074c778cc5138e49e8b3d62022-12-22T01:02:39ZengMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of MedicineScripta Medica2490-33292303-79542019-01-0150269762490-33291902069DHuman papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervixDabeski Drage0Dabeski Ana1Antovska Vesna2Trajanova Milka3Todorovska Irena4Sima Aneta5University Clinic for Gynaecology and Obstetrics, Department of Gynaecology, Skopje, the Republic of North MacedoniaUniversity Clinic for Gynaecology and Obstetrics, Department of Gynaecology, Skopje, the Republic of North MacedoniaUniversity Clinic for Gynaecology and Obstetrics, Department of Gynaecology, Skopje, the Republic of North MacedoniaUniversity Clinic for Gynaecology and Obstetrics, Department of Gynaecology, Skopje, the Republic of North MacedoniaUniversity Clinic for Gynaecology and Obstetrics, Department of Gynaecology, Skopje, the Republic of North MacedoniaUniversity Clinic for Gynaecology and Obstetrics, Department of Gynaecology, Skopje, the Republic of North MacedoniaBackground: Human papillomavirus infections are one of the most common sexually transmitted infections with viral aetiology. The aim of the study was to confirm the existence of an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix. Methods: Cohort study, conducted in the period from January 2017 to June 2018 of 768 sexually active women, age groups of 20 to 59 years, divided into two groups: examined and control, who came to their annual gynaecological exam at University Clinic for Gynaecology and Obstetrics in Skopje. In all patients was done human papillomavirus-deoxyribonucleic testing. Human papillomavirus detection and typing was done using a polymerase chain reaction and reverse hybridisation. Results: Data analysis showed an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix (p=0.00001). Human papillomavirus infection was detected in 22.91% of all patients, in 75.00% of patients with abnormal cervical cytology and in 12.50% of patients with normal cervical cytology. A single human papillomavirus infection was detected in 13.67% of all patients (in 59.66% of human papillomavirus positive patients). Mixed human papillomavirus infection was detected in 9.24% of all patients (in 40.34% of human papillomavirus positive patients). Human papillomavirus type 16 was the most common genotype with 40.91%. Conclusion: This study confirmed that there is an association between human papillomavirus infection and squamous cell abnormalities of the uterine cervix and the young population under the age of 30 years is the most affected.https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2019/2490-33291902069D.pdfhuman papillomavirussquamous cell abnormalitiesuterine cervix |
| spellingShingle | Dabeski Drage Dabeski Ana Antovska Vesna Trajanova Milka Todorovska Irena Sima Aneta Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix Scripta Medica human papillomavirus squamous cell abnormalities uterine cervix |
| title | Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix |
| title_full | Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix |
| title_fullStr | Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix |
| title_full_unstemmed | Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix |
| title_short | Human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix |
| title_sort | human papillomavirus infections in women with and without squamous cell abnormalities of the uterine cervix |
| topic | human papillomavirus squamous cell abnormalities uterine cervix |
| url | https://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2019/2490-33291902069D.pdf |
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