Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome
PCOS (polycystic ovary syndrome) is a common endocrine disorder that affects 8–13% of women of reproductive age. Increased body weight and insulin resistance may be associated with chronic inflammation, which increases the risk of cardiovascular complications. CRP (C-reactive protein) tests may be u...
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MDPI AG
2023-07-01
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| Online Access: | https://www.mdpi.com/2227-9059/11/7/1953 |
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| author | Katarzyna Lejman-Larysz Dominika Pietrzyk Adrianna Ćwiertnia Mateusz Kozłowski Sebastian Kwiatkowski Iwona Szydłowska Jolanta Nawrocka-Rutkowska Jacek Brodowski Elżbieta Sowińska-Przepiera Aneta Cymbaluk-Płoska Agnieszka Brodowska |
| author_facet | Katarzyna Lejman-Larysz Dominika Pietrzyk Adrianna Ćwiertnia Mateusz Kozłowski Sebastian Kwiatkowski Iwona Szydłowska Jolanta Nawrocka-Rutkowska Jacek Brodowski Elżbieta Sowińska-Przepiera Aneta Cymbaluk-Płoska Agnieszka Brodowska |
| author_sort | Katarzyna Lejman-Larysz |
| collection | DOAJ |
| description | PCOS (polycystic ovary syndrome) is a common endocrine disorder that affects 8–13% of women of reproductive age. Increased body weight and insulin resistance may be associated with chronic inflammation, which increases the risk of cardiovascular complications. CRP (C-reactive protein) tests may be use to assess persistent inflammation. Elevated CRP levels may be associated with insulin resistance and type 2 diabetes. Determination of hsCRP, highly sensitive C-reactive protein, can be used to assess cardiovascular risk in women with PCOS. In this study, 120 women between the ages of 18 and 42 were divided into two groups: patients with polycystic ovary syndrome (<i>n</i> = 80) and regular menstruating women in whom PCOS was excluded (<i>n</i> = 40). Lipid and carbohydrate metabolism parameters and hsCRP levels were assessed, followed by receiver operating characteristic (ROC) analysis for hsCRP, where metabolic syndrome was the dependent variable. For hsCRP, the cutoff point was 1.44 (mg/dL). Sensitivity for the cutoff point was 0.913 and specificity was 0.691. The area under the curve (AUC) was 0.851 (<i>p</i> < 0.000). The closer the AUC value is to unity, the better the predictive ability of the studied variable. There was also a statistically significant correlation between hsCRP levels and the presence of metabolic syndrome. |
| first_indexed | 2024-03-11T01:16:58Z |
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| id | doaj.art-c138ad31188f4408a97bb49ea8d7cc43 |
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| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T01:16:58Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-c138ad31188f4408a97bb49ea8d7cc432023-11-18T18:27:21ZengMDPI AGBiomedicines2227-90592023-07-01117195310.3390/biomedicines11071953Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary SyndromeKatarzyna Lejman-Larysz0Dominika Pietrzyk1Adrianna Ćwiertnia2Mateusz Kozłowski3Sebastian Kwiatkowski4Iwona Szydłowska5Jolanta Nawrocka-Rutkowska6Jacek Brodowski7Elżbieta Sowińska-Przepiera8Aneta Cymbaluk-Płoska9Agnieszka Brodowska10Department of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Obstetrics and Gynecology, Pomeranian Medical University in Szczecin, al. Powstaców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandPrimary Care Department, Pomeranian Medical University in Szczecin, Żołnierska 48, 71-210 Szczecin, PolandDepartment of Endocrinology, Metabolic and Internal Diseases, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandDepartment of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University in Szczecin, al. Powstańców Wielkopolskich 72, 70-111 Szczecin, PolandDepartment of Gynecology, Endocrinology and Gynecological Oncology, Pomeranian Medical University in Szczecin, Unii Lubelskiej 1, 71-252 Szczecin, PolandPCOS (polycystic ovary syndrome) is a common endocrine disorder that affects 8–13% of women of reproductive age. Increased body weight and insulin resistance may be associated with chronic inflammation, which increases the risk of cardiovascular complications. CRP (C-reactive protein) tests may be use to assess persistent inflammation. Elevated CRP levels may be associated with insulin resistance and type 2 diabetes. Determination of hsCRP, highly sensitive C-reactive protein, can be used to assess cardiovascular risk in women with PCOS. In this study, 120 women between the ages of 18 and 42 were divided into two groups: patients with polycystic ovary syndrome (<i>n</i> = 80) and regular menstruating women in whom PCOS was excluded (<i>n</i> = 40). Lipid and carbohydrate metabolism parameters and hsCRP levels were assessed, followed by receiver operating characteristic (ROC) analysis for hsCRP, where metabolic syndrome was the dependent variable. For hsCRP, the cutoff point was 1.44 (mg/dL). Sensitivity for the cutoff point was 0.913 and specificity was 0.691. The area under the curve (AUC) was 0.851 (<i>p</i> < 0.000). The closer the AUC value is to unity, the better the predictive ability of the studied variable. There was also a statistically significant correlation between hsCRP levels and the presence of metabolic syndrome.https://www.mdpi.com/2227-9059/11/7/1953polycystic ovary syndrome (PCOS)metabolic syndromehigh-sensitivity C-reactive protein (hsCRP)high-density lipoprotein (HDL)low-density lipoprotein (LDL)obesity |
| spellingShingle | Katarzyna Lejman-Larysz Dominika Pietrzyk Adrianna Ćwiertnia Mateusz Kozłowski Sebastian Kwiatkowski Iwona Szydłowska Jolanta Nawrocka-Rutkowska Jacek Brodowski Elżbieta Sowińska-Przepiera Aneta Cymbaluk-Płoska Agnieszka Brodowska Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome Biomedicines polycystic ovary syndrome (PCOS) metabolic syndrome high-sensitivity C-reactive protein (hsCRP) high-density lipoprotein (HDL) low-density lipoprotein (LDL) obesity |
| title | Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome |
| title_full | Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome |
| title_fullStr | Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome |
| title_full_unstemmed | Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome |
| title_short | Influence of hsCRP Parameter on the Occurrence of Metabolic Syndrome in Patients with Polycystic Ovary Syndrome |
| title_sort | influence of hscrp parameter on the occurrence of metabolic syndrome in patients with polycystic ovary syndrome |
| topic | polycystic ovary syndrome (PCOS) metabolic syndrome high-sensitivity C-reactive protein (hsCRP) high-density lipoprotein (HDL) low-density lipoprotein (LDL) obesity |
| url | https://www.mdpi.com/2227-9059/11/7/1953 |
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