Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease
Higher prevalence of chronic kidney disease (CKD) in women than in men was reported all over the world. This difference could be partly explained by longer life expectancy and slower CKD progression rate in women. Potential factors associated with sex differences in CKD progression are as follows: d...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Medical Society
2023-01-01
|
| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300071D.pdf |
| _version_ | 1797680716793774080 |
|---|---|
| author | Đukanović Ljubica Dimković Nada Ležaić Višnja |
| author_facet | Đukanović Ljubica Dimković Nada Ležaić Višnja |
| author_sort | Đukanović Ljubica |
| collection | DOAJ |
| description | Higher prevalence of chronic kidney disease (CKD) in women than in men was reported all over the world. This difference could be partly explained by longer life expectancy and slower CKD progression rate in women. Potential factors associated with sex differences in CKD progression are as follows: difference in glomerular hemodynamic and the response to angiotensin II; sex hormones – estrogen has protective and testosterone deleterious effects on CKD progression; lifestyle. In most countries, the percentage of men is higher than that of women among incident and prevalent patients on hemodialysis (HD). In HD patients, the Kt/V index overestimates HD adequacy, secondary hyperparathyroidism is more common in women, and women require higher doses of erythropoiesis-stimulating agents for achieving and maintaining the hemoglobin target level. The survival of HD patients is equal for both sexes. In earlier years, an equal percentage of women and men started peritoneal dialysis, but in recent years, a higher percentage of women, especially at younger ages, start peritoneal dialysis. Initial peritoneal transport properties differ between men and women. A smaller percentage of women than men receive deceased donor kidneys, but women are more likely to be living kidney donors. Kidney allograft outcome depends on the sex and age of both the recipient and the donor. Cardiovascular diseases are the most common cause of death for renal replacement therapy patients of both sexes. Although sex-specific differences have been described in CKD patients, the inequality of patients in access to medical care has not been found in most regions of the world. |
| first_indexed | 2024-03-11T23:34:09Z |
| format | Article |
| id | doaj.art-c1393b34ecd945a794c5525422d1aa44 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-03-11T23:34:09Z |
| publishDate | 2023-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-c1393b34ecd945a794c5525422d1aa442023-09-20T06:03:11ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952023-01-011517-849349810.2298/SARH230321071D0370-81792300071DSex-specific differences in the epidemiology, progression, and outcomes of chronic kidney diseaseĐukanović Ljubica0Dimković Nada1https://orcid.org/0000-0002-9553-777XLežaić Višnja2Academy of Medical Sciences of the Serbian Medical Society, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaAcademy of Medical Sciences of the Serbian Medical Society, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaAcademy of Medical Sciences of the Serbian Medical Society, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, SerbiaHigher prevalence of chronic kidney disease (CKD) in women than in men was reported all over the world. This difference could be partly explained by longer life expectancy and slower CKD progression rate in women. Potential factors associated with sex differences in CKD progression are as follows: difference in glomerular hemodynamic and the response to angiotensin II; sex hormones – estrogen has protective and testosterone deleterious effects on CKD progression; lifestyle. In most countries, the percentage of men is higher than that of women among incident and prevalent patients on hemodialysis (HD). In HD patients, the Kt/V index overestimates HD adequacy, secondary hyperparathyroidism is more common in women, and women require higher doses of erythropoiesis-stimulating agents for achieving and maintaining the hemoglobin target level. The survival of HD patients is equal for both sexes. In earlier years, an equal percentage of women and men started peritoneal dialysis, but in recent years, a higher percentage of women, especially at younger ages, start peritoneal dialysis. Initial peritoneal transport properties differ between men and women. A smaller percentage of women than men receive deceased donor kidneys, but women are more likely to be living kidney donors. Kidney allograft outcome depends on the sex and age of both the recipient and the donor. Cardiovascular diseases are the most common cause of death for renal replacement therapy patients of both sexes. Although sex-specific differences have been described in CKD patients, the inequality of patients in access to medical care has not been found in most regions of the world.https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300071D.pdfsex-specific differenceschronic kidney diseaseprevalenceprogressionrenal replacement therapy |
| spellingShingle | Đukanović Ljubica Dimković Nada Ležaić Višnja Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease Srpski Arhiv za Celokupno Lekarstvo sex-specific differences chronic kidney disease prevalence progression renal replacement therapy |
| title | Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease |
| title_full | Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease |
| title_fullStr | Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease |
| title_full_unstemmed | Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease |
| title_short | Sex-specific differences in the epidemiology, progression, and outcomes of chronic kidney disease |
| title_sort | sex specific differences in the epidemiology progression and outcomes of chronic kidney disease |
| topic | sex-specific differences chronic kidney disease prevalence progression renal replacement therapy |
| url | https://doiserbia.nb.rs/img/doi/0370-8179/2023/0370-81792300071D.pdf |
| work_keys_str_mv | AT đukanovicljubica sexspecificdifferencesintheepidemiologyprogressionandoutcomesofchronickidneydisease AT dimkovicnada sexspecificdifferencesintheepidemiologyprogressionandoutcomesofchronickidneydisease AT lezaicvisnja sexspecificdifferencesintheepidemiologyprogressionandoutcomesofchronickidneydisease |