The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells

The Impact of Acquired Genetic Abnormalities on the Clinical Translation of Human Pluripotent Stem Cells

Human pluripotent stem cells (hPSC) are known to acquire chromosomal abnormalities, which range from point mutations to large copy number changes, including full chromosome aneuploidy. These aberrations have a wide-ranging influence on the state of cells, in both the undifferentiated and differentia...

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Bibliographic Details
Main Authors:	Alexander Keller, Claudia Spits
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Cells
Subjects:	pluripotent stem cells embryonic stem cells induced pluripotent stem cells genomic instability differentiation clinical translation
Online Access:	https://www.mdpi.com/2073-4409/10/11/3246

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