Improved Release of a Drug with Poor Water Solubility by Using Electrospun Water-Soluble Polymers as Carriers

Improved Release of a Drug with Poor Water Solubility by Using Electrospun Water-Soluble Polymers as Carriers

In an attempt to improve the solubility of valsartan, a BCS II drug, fibers containing the drug were prepared from three water-soluble polymers, hydroxypropyl-methyl-cellulose (HPMC), polyvinyl-pyrrolidone (PVP), and polyvinyl-alcohol (PVA). Fiber spinning technology was optimized for each polymer s...

Full description

Bibliographic Details
Main Authors:	Muriel Józó, Nóra Simon, Lan Yi, János Móczó, Béla Pukánszky
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Series:	Pharmaceutics
Subjects:	valsartan hydroxypropyl-methyl-cellulose polyvinyl-pyrrolidone polyvinyl-alcohol drug morphology distribution
Online Access:	https://www.mdpi.com/1999-4923/14/1/34

Similar Items

Properties of Bacterial Cellulose/Polyvinyl Composite Membrane for Polymer Electrolyte Li ion Battery
by: Qolby Sabrina, et al.
Published: (2023-04-01)

Effect of Polyvinyl Pyrrolidone on Polyvinyl Chloride-Graft-Acrylamide Membranes
by: Maha Al-Bahate, et al.
Published: (2020-09-01)

Fabrication of Tizanidine Loaded Patches Using Flaxseed Oil and Coriander Oil as a Penetration Enhancer for Transdermal Delivery
by: Muhammad Akhlaq, et al.
Published: (2021-12-01)

Synthesis of Ag3PO4 using Hydrophylic Polymer and Their Photocatalytic Activities under Visible Light Irradiation
by: Uyi Sulaeman, et al.
Published: (2017-08-01)

Preparation and Properties of Asymmetric Polyvinyl Pyrroli-Done/Polycaprolactone Composite Nanofiber Loaded with Tea Tree Extract
by: Yu Xu, et al.
Published: (2022-09-01)

Synthesis and Characterization of Monodispersed Copper Colloids in Polar Solvents
by: Yu Wei, et al.
Published: (2009-01-01)

Preparation and Characterization of Carbamazepine Cocrystal in Polymer Solution
by: Hao Zhang, et al.
Published: (2017-12-01)

Preparation and in Vitro Evaluation for Different Types of Ondansetron Hydrochloride Transdermal Patches
by: Karima Abd allatif, et al.
Published: (2023-06-01)

Levocetirizine-Loaded Electrospun Fibers from Water-Soluble Polymers: Encapsulation and Drug Release
by: Lan Yi, et al.
Published: (2023-05-01)

Ternary cyclodextrin systems of terbinafine hydrochloride inclusion complexes: Solventless preparation, solid-state, and in vitro characterization
by: Balázs Attila Kondoros, et al.
Published: (2023-11-01)

Porous Film Coating Enabled by Polyvinyl Pyrrolidone (PVP) for Enhanced Air Permeability of Fabrics: The Effect of PVP Molecule Weight and Dosage
by: Jiantang Jiang, et al.
Published: (2020-12-01)

A Study on the Improvement of Using Raw Lacquer and Electrospinning on Properties of PVP Nanofilms
by: Kunlin Wu, et al.
Published: (2020-08-01)

Eco-Friendly Chitosan-Based Biodiesel Heterogeneous Catalyst Support Membrane
by: Retno Ariadi Lusiana, et al.
Published: (2023-02-01)

Efficiency of Fenbendazole on the Basis of Nanosized Supramolecular Delivery Systems with Polyvinyl Pyrrolidone and Dioctylsulphosuccinate Sodium in the Cases of Helminthosis
by: A. I. Varlamova, et al.
Published: (2020-05-01)

Preparation of Nanofibres from Phenol Liquefied Wood by Electrospinning
by: Zhifan Tian, et al.
Published: (2016-02-01)

Effect of PVP Coating on LiMnBO<sub>3</sub> Cathodes for Li-Ion Batteries
by: Bolong Hong, et al.
Published: (2020-12-01)

Transdermal drug delivery of crocin using electrospun polyvinyl alcohol by Franz diffusion /
by: Muhammad Syafiq Mohd. Najib, 1981- , author 612397
Published: (2018)

Transdermal drug delivery of crocin using electrospun polyvinyl alcohol by Franz diffusion /
by: Muhammad Syafiq Mohd. Najib, 1981- , author 612397
Published: (2018)

Innovative Methylcellulose-Polyvinyl Pyrrolidone-Based Solid Polymer Electrolytes Impregnated with Potassium Salt: Ion Conduction and Thermal Properties
by: Abdullahi Abbas Adam, et al.
Published: (2022-07-01)

Influences of NaCl and Na<sub>2</sub>SO<sub>4</sub> on the Micellization Behavior of the Mixture of Cetylpyridinium Chloride + Polyvinyl Pyrrolidone at Several Temperatures
by: Md. Farid Ahmed, et al.
Published: (2022-01-01)

A Water-Soluble Epoxy-Based Green Crosslinking System for Stabilizing PVA Nanofibers
by: Yujian Zhang, et al.
Published: (2022-06-01)

Innovative fully soluble NPK gel fertilizers based on biopolymers with controlled release of nutrients
by: Ikramov Muboshir, et al.
Published: (2023-01-01)

Preparation and Characterization of Hydrophilic Polymer Based Sustained-Release Matrix Tablets of a High Dose Hydrophobic Drug
by: Niaz Ali Khan, et al.
Published: (2022-05-01)

Enhanced Hydrophilic and Electrophilic Properties of Polyvinyl Chloride (PVC) Biofilm Carrier
by: Haifeng Cai, et al.
Published: (2020-05-01)

Synthesis and Characterization of Silver Nanoparticle-Polydimethylsiloxane (Ag-NP-PDMS) Stretchable Conductive Nanocomposites
by: Abdul Rauf Jamali, et al.
Published: (2022-08-01)

Design and Evaluation of Dissolving Microneedles for Enhanced Dermal Delivery of Propranolol Hydrochloride
by: Jingjing He, et al.
Published: (2021-04-01)

Optimized Loading of Carboxymethyl Cellulose (CMC) in Tri-component Electrospun Nanofibers Having Uniform Morphology
by: Motahira Hashmi, et al.
Published: (2020-10-01)

Effect of Cellulose Nanocrystals and Lignin Nanoparticles on Mechanical, Antioxidant and Water Vapour Barrier Properties of Glutaraldehyde Crosslinked PVA Films
by: Weijun Yang, et al.
Published: (2020-06-01)

Peningkatan kekuatan hentaman bagi PVC-U /
by: 246350 Lee, Chao Yang
Published: (1998)

Kesan saiz zarah pengisi keatas kekuatan hentaman PVC-U /
by: 249907 Syamsul Ariff Hanafiah
Published: (1999)

New poly(vinyl chloride)-based blends : aspects of processability (Part I) /
by: Rusu, Mihai

Preparation of Needleless Electrospinning Polyvinyl Alcohol/Water-Soluble Chitosan Nanofibrous Membranes: Antibacterial Property and Filter Efficiency
by: Ching-Wen Lou, et al.
Published: (2022-03-01)

Preparation and characterization of anticorrosive and antibacterial coatable nanocomposite based on zinc phosphate modified by Hydroxy Apatite/alginate: Investigation of electrochemical impedance spectroscopy (EIS)
by: Arezoo Mohammadkhani, et al.
Published: (2024-06-01)

Effect of Surfactant Polyvinyl Pyrrolidone on the Properties of Microporous Carbon Nanospheres Reinforced Magnesium Matrix Composites
by: Lin Jin, et al.
Published: (2020-11-01)

Fabrication of solid lipid nanoparticles-based patches of paroxetine and their ex-vivo permeation behaviour
by: Fahad Pervaiz, et al.
Published: (2023-12-01)

Synthesis and Characterization of Slow-Release Fertilizer Hydrogel Based on Hydroxy Propyl Methyl Cellulose, Polyvinyl Alcohol, Glycerol and Blended Paper
by: Semiu A. Kareem, et al.
Published: (2021-12-01)

In Vivo Evaluation of a Gastro-Resistant Enprotect<sup>®</sup> Capsule under Postprandial Conditions
by: Michael Grimm, et al.
Published: (2023-11-01)

In Vivo Evaluation of a Gastro-Resistant HPMC-Based “Next Generation Enteric” Capsule
by: Adrian Rump, et al.
Published: (2022-09-01)

Safety of feed additives consisting of hydroxypropyl methyl cellulose (E 464) and methyl cellulose (E 461) for all animal species (International Cellulosics Association)
by: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), et al.
Published: (2024-02-01)

A developed composite hard-gelatin capsules: delayed-release enteric properties
by: Mozhgan Nezhad Mohseni, et al.
Published: (2022-12-01)