The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP

Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart f...

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Main Authors: Victoria Sircu, Silvia-Iaroslava Colesnic, Serghei Covantsev, Olga Corlateanu, Anna Sukhotko, Cristian Popovici, Alexandru Corlateanu
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Clocks & Sleep
Subjects:
Online Access:https://www.mdpi.com/2624-5175/5/2/25
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author Victoria Sircu
Silvia-Iaroslava Colesnic
Serghei Covantsev
Olga Corlateanu
Anna Sukhotko
Cristian Popovici
Alexandru Corlateanu
author_facet Victoria Sircu
Silvia-Iaroslava Colesnic
Serghei Covantsev
Olga Corlateanu
Anna Sukhotko
Cristian Popovici
Alexandru Corlateanu
author_sort Victoria Sircu
collection DOAJ
description Micro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.
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spelling doaj.art-c13acf83e5fa40dca2d7844cfcceb3da2023-11-18T09:53:12ZengMDPI AGClocks & Sleep2624-51752023-06-015233334910.3390/clockssleep5020025The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAPVictoria Sircu0Silvia-Iaroslava Colesnic1Serghei Covantsev2Olga Corlateanu3Anna Sukhotko4Cristian Popovici5Alexandru Corlateanu6Division of Pneumology and Allergology, Department of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, MoldovaDivision of Pneumology and Allergology, Department of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, MoldovaDepartment of Clinical Research and Development, Botkin Hospital, 125284 Moscow, RussiaDepartment of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, MoldovaDepartment of General Oncology № 71, Botkin Hospital, 125284 Moscow, RussiaDivision of Pneumology and Allergology, Department of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, MoldovaDivision of Pneumology and Allergology, Department of Internal Medicine, State University of Medicine and Pharmacy Nicolae Testemitanu, MD-2004 Chisinau, MoldovaMicro-arousals and the repeated desaturation of oxyhemoglobin, which are typical in obstructive sleep apnea syndrome (OSAS), have adverse effects on the health of patients, leading to a wide range of complications such as cardiovascular (arterial hypertension, pulmonary hypertension, chronic heart failure, arrhythmias, myocardial infarction), cerebrovascular (strokes), metabolic (insulin resistance, obesity, diabetes mellitus, metabolic syndrome), gastrointestinal (non-alcoholic liver disease), urinary (chronic renal failure), and neuropsychiatric complications as well as a wide range of malignancies. These, in turn, have multilateral effects on familial, occupational, and social life, as well as increasing the risks of road traffic accidents and accidents at the workplace. Awareness, timely screening, and the prevention of complications play important roles in diagnosing and treating comorbid conditions. This review focuses on comorbidities in OSAS and the effect of Continuous Positive Airway Pressure (CPAP) therapy on their prognoses.https://www.mdpi.com/2624-5175/5/2/25OSASCPAPdiabetes mellitushypertensionischemic heart diseasestroke
spellingShingle Victoria Sircu
Silvia-Iaroslava Colesnic
Serghei Covantsev
Olga Corlateanu
Anna Sukhotko
Cristian Popovici
Alexandru Corlateanu
The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP
Clocks & Sleep
OSAS
CPAP
diabetes mellitus
hypertension
ischemic heart disease
stroke
title The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP
title_full The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP
title_fullStr The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP
title_full_unstemmed The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP
title_short The Burden of Comorbidities in Obstructive Sleep Apnea and the Pathophysiologic Mechanisms and Effects of CPAP
title_sort burden of comorbidities in obstructive sleep apnea and the pathophysiologic mechanisms and effects of cpap
topic OSAS
CPAP
diabetes mellitus
hypertension
ischemic heart disease
stroke
url https://www.mdpi.com/2624-5175/5/2/25
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