Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis
Background: Due to the limited number of studies, failure to adequately investigating the impact of miltefosine in the treatment of cutaneous leishmaniasis, and the fact that faster recovery of injuries causes less scarring for the patient, the present study aimed to investigate the effect of topica...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2014-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/2042 |
| _version_ | 1797719748694245376 |
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| author | Ali Asilian Shaghayegh Omrani Mohammad Ail Nilforoushzadeh |
| author_facet | Ali Asilian Shaghayegh Omrani Mohammad Ail Nilforoushzadeh |
| author_sort | Ali Asilian |
| collection | DOAJ |
| description | Background: Due to the limited number of studies, failure to adequately investigating the impact of miltefosine in the treatment of cutaneous leishmaniasis, and the fact that faster recovery of injuries causes less scarring for the patient, the present study aimed to investigate the effect of topical miltefosine on the treatment of cutaneous leishmaniasis.
Methods: In this clinical trial study, 64 patients with cutaneous leishmaniasis were equally treated in two groups with miltefosine and Glucantime. The first group of patients was treated with localized Glucantime 2 times a week (up to 28 days) and the second group was treated with localized miltefosine (ointment 6%), once daily (for 28 days), in a way that the lesion was completely smeared with the ointment. Patients were examined every week during treatment and the lesion size was recorded. All the patients’ lesions regarding their appearance, wound size, induration, erythema, and lesion size during weekly visits, at end of the treatment, and one month after the treatment were assessed.
Findings: Mean age of the patients was 23.12 ± 13.30 years. The cure rate was 34.4% in patients treated with topical Glucantime, and 53.1% in the patients treated with topical miltefosine (P = 0.010). 1 month after the treatment, the cure rate was 50% in patients treated with topical Glucantime, and 81.3% in patients treated with miltefosine (P = 0.300). Mean size of the remaining scar caused by cutaneous leishmaniasis was 1.9 cm in the group treated with Glucantime, and 0.9 cm in the group treated with miltefosine (P = 0.001).
Conclusion: According to the results of this study and other studies in this area, it can be concluded that topical miltefosine can treat the lesions faster than intralesional Glucantime injection. In addition, patients treated with topical miltefosine had smaller scars. |
| first_indexed | 2024-03-12T09:09:17Z |
| format | Article |
| id | doaj.art-c13b1002b2de484ab9e6009483e31996 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:09:17Z |
| publishDate | 2014-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-c13b1002b2de484ab9e6009483e319962023-09-02T15:06:20ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2014-03-0131269225722631503Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous LeishmaniasisAli Asilian0Shaghayegh Omrani1Mohammad Ail Nilforoushzadeh2Professor, Skin Disease and Leishmaniasis Research Center AND Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranGeneral Practitioner, Skin Disease and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, IranBackground: Due to the limited number of studies, failure to adequately investigating the impact of miltefosine in the treatment of cutaneous leishmaniasis, and the fact that faster recovery of injuries causes less scarring for the patient, the present study aimed to investigate the effect of topical miltefosine on the treatment of cutaneous leishmaniasis. Methods: In this clinical trial study, 64 patients with cutaneous leishmaniasis were equally treated in two groups with miltefosine and Glucantime. The first group of patients was treated with localized Glucantime 2 times a week (up to 28 days) and the second group was treated with localized miltefosine (ointment 6%), once daily (for 28 days), in a way that the lesion was completely smeared with the ointment. Patients were examined every week during treatment and the lesion size was recorded. All the patients’ lesions regarding their appearance, wound size, induration, erythema, and lesion size during weekly visits, at end of the treatment, and one month after the treatment were assessed. Findings: Mean age of the patients was 23.12 ± 13.30 years. The cure rate was 34.4% in patients treated with topical Glucantime, and 53.1% in the patients treated with topical miltefosine (P = 0.010). 1 month after the treatment, the cure rate was 50% in patients treated with topical Glucantime, and 81.3% in patients treated with miltefosine (P = 0.300). Mean size of the remaining scar caused by cutaneous leishmaniasis was 1.9 cm in the group treated with Glucantime, and 0.9 cm in the group treated with miltefosine (P = 0.001). Conclusion: According to the results of this study and other studies in this area, it can be concluded that topical miltefosine can treat the lesions faster than intralesional Glucantime injection. In addition, patients treated with topical miltefosine had smaller scars.http://jims.mui.ac.ir/index.php/jims/article/view/2042GlucantimeMiltefosineCutaneous leishmaniasisTreatment |
| spellingShingle | Ali Asilian Shaghayegh Omrani Mohammad Ail Nilforoushzadeh Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis مجله دانشکده پزشکی اصفهان Glucantime Miltefosine Cutaneous leishmaniasis Treatment |
| title | Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis |
| title_full | Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis |
| title_fullStr | Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis |
| title_full_unstemmed | Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis |
| title_short | Comparing the Effects of Topical Miltefosine and Glucantime in Treatment of Cutaneous Leishmaniasis |
| title_sort | comparing the effects of topical miltefosine and glucantime in treatment of cutaneous leishmaniasis |
| topic | Glucantime Miltefosine Cutaneous leishmaniasis Treatment |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/2042 |
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