Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity
Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on wh...
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MDPI AG
2016-08-01
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author | Ameyalli Grasa-López Ángel Miliar-García Lucía Quevedo-Corona Norma Paniagua-Castro Gerardo Escalona-Cardoso Elba Reyes-Maldonado María-Eugenia Jaramillo-Flores |
author_facet | Ameyalli Grasa-López Ángel Miliar-García Lucía Quevedo-Corona Norma Paniagua-Castro Gerardo Escalona-Cardoso Elba Reyes-Maldonado María-Eugenia Jaramillo-Flores |
author_sort | Ameyalli Grasa-López |
collection | DOAJ |
description | Brown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related. |
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issn | 1660-3397 |
language | English |
last_indexed | 2024-04-11T13:46:34Z |
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publisher | MDPI AG |
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spelling | doaj.art-c13b3b2feb654b818d637a91e33100ce2022-12-22T04:21:05ZengMDPI AGMarine Drugs1660-33972016-08-0114814810.3390/md14080148md14080148Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced ObesityAmeyalli Grasa-López0Ángel Miliar-García1Lucía Quevedo-Corona2Norma Paniagua-Castro3Gerardo Escalona-Cardoso4Elba Reyes-Maldonado5María-Eugenia Jaramillo-Flores6Departamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoLaboratorio de Biología Molecular, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoDepartamento de Fisiologia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoDepartamento de Fisiologia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoDepartamento de Fisiologia, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoDepartamento de Morfología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 11340, MexicoDepartamento de Ingeniería Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México 07738, MexicoBrown algae and its carotenoids have been shown to have a positive influence on obesity and its comorbidities. This study evaluated the effect of Undaria pinnatifida and fucoxanthin on biochemical, physiological and inflammation markers related to obesity and on the expression of genes engaged on white adipose tissue lipid metabolism in a murine model of diet-induced obesity. The treatments improved energy expenditure, β-oxidation and adipogenesis by upregulating PPARα, PGC1α, PPARγ and UCP-1. Adipogenesis was also confirmed by image analysis of the retroperitoneal adipose tissue, by measuring cell area, perimeter and cellular density. Additionally, the treatments, ameliorated adipose tissue accumulation, insulin resistance, blood pressure, cholesterol and triglycerides concentration in serum, and reduced lipogenesis and inflammation by downregulating acetyl-CoA carboxylase (ACC) gene expression, increasing serum concentration and expression of adiponectin as well as downregulating IL-6 expression. Both fucoxanthin and Undaria pinnatifida may be considered for treating obesity and other diseases related.http://www.mdpi.com/1660-3397/14/8/148fucoxanthinUndaria pinnatifidaobesityinflammationenergy expenditureadipose tissue expansiongene expression |
spellingShingle | Ameyalli Grasa-López Ángel Miliar-García Lucía Quevedo-Corona Norma Paniagua-Castro Gerardo Escalona-Cardoso Elba Reyes-Maldonado María-Eugenia Jaramillo-Flores Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity Marine Drugs fucoxanthin Undaria pinnatifida obesity inflammation energy expenditure adipose tissue expansion gene expression |
title | Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity |
title_full | Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity |
title_fullStr | Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity |
title_full_unstemmed | Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity |
title_short | Undaria pinnatifida and Fucoxanthin Ameliorate Lipogenesis and Markers of Both Inflammation and Cardiovascular Dysfunction in an Animal Model of Diet-Induced Obesity |
title_sort | undaria pinnatifida and fucoxanthin ameliorate lipogenesis and markers of both inflammation and cardiovascular dysfunction in an animal model of diet induced obesity |
topic | fucoxanthin Undaria pinnatifida obesity inflammation energy expenditure adipose tissue expansion gene expression |
url | http://www.mdpi.com/1660-3397/14/8/148 |
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