Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease
Malnutrition has a negative impact on patients with chronic pulmonary obstructive disease (COPD). The purpose of this study was to assess the prevalence of malnutrition, defined by the Global Leadership Initiative for Malnutrition (GLIM), in stable COPD patients referred to pulmonary rehabilitation,...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
|
| Series: | Nutrients |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6643/13/2/369 |
| _version_ | 1797407393703788544 |
|---|---|
| author | Vanesa Dávalos-Yerovi Ester Marco Dolores Sánchez-Rodríguez Xavier Duran Delky Meza-Valderrama Diego A. Rodríguez Elena Muñoz Marta Tejero-Sánchez Maria Dolors Muns Anna Guillén-Solà Esther Duarte |
| author_facet | Vanesa Dávalos-Yerovi Ester Marco Dolores Sánchez-Rodríguez Xavier Duran Delky Meza-Valderrama Diego A. Rodríguez Elena Muñoz Marta Tejero-Sánchez Maria Dolors Muns Anna Guillén-Solà Esther Duarte |
| author_sort | Vanesa Dávalos-Yerovi |
| collection | DOAJ |
| description | Malnutrition has a negative impact on patients with chronic pulmonary obstructive disease (COPD). The purpose of this study was to assess the prevalence of malnutrition, defined by the Global Leadership Initiative for Malnutrition (GLIM), in stable COPD patients referred to pulmonary rehabilitation, and to explore potential associations of malnutrition according to GLIM, and its components, with increased risk of mortality and hospitalizations in 2 years. In a post-hoc analysis of a prospective cohort of 200 rehabilitation patients with stable COPD, main outcome variables were hospital admissions, length of stay, and mortality during a 2-year follow-up. Covariates were malnutrition according to GLIM and its phenotypic criteria: unintentional weight loss, low body mass index (BMI), and low fat-free mass (FFM). Univariate and multivariate analysis were performed using logistic and proportional hazard Cox regression. Malnutrition according to GLIM showed 45% prevalence and was associated with increased mortality risk. Low age-related BMI and FFM were independently associated with mortality, which persisted after adjustment for age and lung function. Malnutrition and low BMI were also associated with increased risk of hospitalization. Malnutrition according to GLIM criteria was highly prevalent in rehabilitation patients with COPD and was associated with nearly 3 times greater mortality and hospitalization risk. |
| first_indexed | 2024-03-09T03:40:46Z |
| format | Article |
| id | doaj.art-c13b9355777d4c1fab2de8fdd34f05d6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:40:46Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c13b9355777d4c1fab2de8fdd34f05d62023-12-03T14:41:41ZengMDPI AGNutrients2072-66432021-01-0113236910.3390/nu13020369Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary DiseaseVanesa Dávalos-Yerovi0Ester Marco1Dolores Sánchez-Rodríguez2Xavier Duran3Delky Meza-Valderrama4Diego A. Rodríguez5Elena Muñoz6Marta Tejero-Sánchez7Maria Dolors Muns8Anna Guillén-Solà9Esther Duarte10Physical Medicine and Rehabilitation Department, Parc Salut Mar (Hospital del Mar Hospital de l’Esperança), Passeig Maritim de la Barceloneta 25-29, 08003 Barcelona, SpainPhysical Medicine and Rehabilitation Department, Parc Salut Mar (Hospital del Mar Hospital de l’Esperança), Passeig Maritim de la Barceloneta 25-29, 08003 Barcelona, SpainRehabilitation Research Group, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Carrer del Doctor Aiguader 88, 08003 Barcelona, SpainMethodology and Biostatistics Support Unit, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Carrer del Doctor Aiguader 88, 08003 Barcelona, SpainRehabilitation Research Group, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Carrer del Doctor Aiguader 88, 08003 Barcelona, SpainSchool of Medicine, Universitat Autònoma de Barcelona (UAB), Campus Universitari Mar, Carrer del Doctor Aiguader 80, 08003 Barcelona, SpainRehabilitation Research Group, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Carrer del Doctor Aiguader 88, 08003 Barcelona, SpainPhysical Medicine and Rehabilitation Department, Parc Salut Mar (Hospital del Mar Hospital de l’Esperança), Passeig Maritim de la Barceloneta 25-29, 08003 Barcelona, SpainRehabilitation Research Group, Institut Hospital del Mar d’Investigacions Mèdiques (IMIM), Carrer del Doctor Aiguader 88, 08003 Barcelona, SpainPhysical Medicine and Rehabilitation Department, Parc Salut Mar (Hospital del Mar Hospital de l’Esperança), Passeig Maritim de la Barceloneta 25-29, 08003 Barcelona, SpainPhysical Medicine and Rehabilitation Department, Parc Salut Mar (Hospital del Mar Hospital de l’Esperança), Passeig Maritim de la Barceloneta 25-29, 08003 Barcelona, SpainMalnutrition has a negative impact on patients with chronic pulmonary obstructive disease (COPD). The purpose of this study was to assess the prevalence of malnutrition, defined by the Global Leadership Initiative for Malnutrition (GLIM), in stable COPD patients referred to pulmonary rehabilitation, and to explore potential associations of malnutrition according to GLIM, and its components, with increased risk of mortality and hospitalizations in 2 years. In a post-hoc analysis of a prospective cohort of 200 rehabilitation patients with stable COPD, main outcome variables were hospital admissions, length of stay, and mortality during a 2-year follow-up. Covariates were malnutrition according to GLIM and its phenotypic criteria: unintentional weight loss, low body mass index (BMI), and low fat-free mass (FFM). Univariate and multivariate analysis were performed using logistic and proportional hazard Cox regression. Malnutrition according to GLIM showed 45% prevalence and was associated with increased mortality risk. Low age-related BMI and FFM were independently associated with mortality, which persisted after adjustment for age and lung function. Malnutrition and low BMI were also associated with increased risk of hospitalization. Malnutrition according to GLIM criteria was highly prevalent in rehabilitation patients with COPD and was associated with nearly 3 times greater mortality and hospitalization risk.https://www.mdpi.com/2072-6643/13/2/369malnutritionGLIMmortalityhospitalizationchronic pulmonary obstructive diseaserehabilitation |
| spellingShingle | Vanesa Dávalos-Yerovi Ester Marco Dolores Sánchez-Rodríguez Xavier Duran Delky Meza-Valderrama Diego A. Rodríguez Elena Muñoz Marta Tejero-Sánchez Maria Dolors Muns Anna Guillén-Solà Esther Duarte Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease Nutrients malnutrition GLIM mortality hospitalization chronic pulmonary obstructive disease rehabilitation |
| title | Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_full | Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_fullStr | Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_full_unstemmed | Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_short | Malnutrition According to GLIM Criteria Is Associated with Mortality and Hospitalizations in Rehabilitation Patients with Stable Chronic Obstructive Pulmonary Disease |
| title_sort | malnutrition according to glim criteria is associated with mortality and hospitalizations in rehabilitation patients with stable chronic obstructive pulmonary disease |
| topic | malnutrition GLIM mortality hospitalization chronic pulmonary obstructive disease rehabilitation |
| url | https://www.mdpi.com/2072-6643/13/2/369 |
| work_keys_str_mv | AT vanesadavalosyerovi malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT estermarco malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT doloressanchezrodriguez malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT xavierduran malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT delkymezavalderrama malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT diegoarodriguez malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT elenamunoz malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT martatejerosanchez malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT mariadolorsmuns malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT annaguillensola malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease AT estherduarte malnutritionaccordingtoglimcriteriaisassociatedwithmortalityandhospitalizationsinrehabilitationpatientswithstablechronicobstructivepulmonarydisease |