Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy
Brillouin imaging (BI) for micromechanical characterization of tissues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells. Although the principles of BI imply its compatibility with in vivo and in situ measureme...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2017-11-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545817420020 |
| _version_ | 1818245968497213440 |
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| author | Irina V. Kabakova YuChen Xiang Carl Paterson Peter Török |
| author_facet | Irina V. Kabakova YuChen Xiang Carl Paterson Peter Török |
| author_sort | Irina V. Kabakova |
| collection | DOAJ |
| description | Brillouin imaging (BI) for micromechanical characterization of tissues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells. Although the principles of BI imply its compatibility with in vivo and in situ measurements, the integration of BI with a flexible catheter, capable of reaching the region of interest within the body, is yet to be reported. Here, for the first time, we experimentally investigate integration of the Brillouin spectroscope with standard optical fiber components to achieve a Brillouin endoscope. The performance of single-fiber and dual-fiber endoscopes are demonstrated and analyzed. We show that a major challenge in construction of Brillouin endoscopes is the strong backward Brillouin scattering in the optical fiber and we present a dual-fiber geometry as a possible solution. Measurements of Brillouin spectra in test liquids (water, ethanol and glycerol) are demonstrated using the dual-fiber endoscope and its performance is analyzed numerically with the help of a beam propagation model. |
| first_indexed | 2024-12-12T14:41:21Z |
| format | Article |
| id | doaj.art-c13c2562947942d78130faa54c0a130c |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-12-12T14:41:21Z |
| publishDate | 2017-11-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-c13c2562947942d78130faa54c0a130c2022-12-22T00:21:15ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052017-11-011061742002-11742002-910.1142/S179354581742002010.1142/S1793545817420020Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopyIrina V. Kabakova0YuChen Xiang1Carl Paterson2Peter Török3Blackett Laboratory, Imperial College London, Prince Consort Road SW7 2AZ, London, UKBlackett Laboratory, Imperial College London, Prince Consort Road SW7 2AZ, London, UKBlackett Laboratory, Imperial College London, Prince Consort Road SW7 2AZ, London, UKBlackett Laboratory, Imperial College London, Prince Consort Road SW7 2AZ, London, UKBrillouin imaging (BI) for micromechanical characterization of tissues and biomaterials is a fast-developing field of research with a strong potential for medical diagnosis of disease-modified tissues and cells. Although the principles of BI imply its compatibility with in vivo and in situ measurements, the integration of BI with a flexible catheter, capable of reaching the region of interest within the body, is yet to be reported. Here, for the first time, we experimentally investigate integration of the Brillouin spectroscope with standard optical fiber components to achieve a Brillouin endoscope. The performance of single-fiber and dual-fiber endoscopes are demonstrated and analyzed. We show that a major challenge in construction of Brillouin endoscopes is the strong backward Brillouin scattering in the optical fiber and we present a dual-fiber geometry as a possible solution. Measurements of Brillouin spectra in test liquids (water, ethanol and glycerol) are demonstrated using the dual-fiber endoscope and its performance is analyzed numerically with the help of a beam propagation model.http://www.worldscientific.com/doi/pdf/10.1142/S1793545817420020Brillouin imagingfiber integrationendoscope |
| spellingShingle | Irina V. Kabakova YuChen Xiang Carl Paterson Peter Török Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy Journal of Innovative Optical Health Sciences Brillouin imaging fiber integration endoscope |
| title | Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy |
| title_full | Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy |
| title_fullStr | Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy |
| title_full_unstemmed | Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy |
| title_short | Fiber-integrated Brillouin microspectroscopy: Towards Brillouin endoscopy |
| title_sort | fiber integrated brillouin microspectroscopy towards brillouin endoscopy |
| topic | Brillouin imaging fiber integration endoscope |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545817420020 |
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