Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Suppress the Proliferation of Multiple Myeloma Cells by Down-Regulating the Level of β-Catenin

Ilimaquinone and Ethylsmenoquinone, Marine Sponge Metabolites, Suppress the Proliferation of Multiple Myeloma Cells by Down-Regulating the Level of β-Catenin

Deregulation of Wnt/β-catenin signaling promotes the development of a broad range of human cancers, including multiple myeloma, and is thus a potential target for the development of therapeutics for this disease. Here, we used a cell-based reporter system to demonstrate that ilimaquinone and ethyls...

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Bibliographic Details
Main Authors: Seoyoung Park, Eunju Yun, In Hyun Hwang, Soojin Yoon, Dong-Eun Kim, Ji Seon Kim, MinKyun Na, Gyu-Yong Song, Sangtaek Oh
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:Marine Drugs
Subjects:
ilimaquinone
ethylsmenoquinone
Wnt/β-catenin signaling
multiple myeloma
Online Access:http://www.mdpi.com/1660-3397/12/6/3231

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