Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma
Objective To investigate the significance of metabolic parameters and biochemical indexes of 18F-FDG-PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma （DLBCL）. Methods Clinical data of 194 patients with DLBCL were analyzed retrospectively. The mid-term evaluation resul...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-03-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1648889513501-1177169121.pdf |
| _version_ | 1797987366140379136 |
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| author | Zhang Fan, Zhang Guoxu, Liu Xiuting, Wang Jigang, Liu Yanqin, Tong Danjiang, Liu Jinghua, Zhou Fan |
| author_facet | Zhang Fan, Zhang Guoxu, Liu Xiuting, Wang Jigang, Liu Yanqin, Tong Danjiang, Liu Jinghua, Zhou Fan |
| author_sort | Zhang Fan, Zhang Guoxu, Liu Xiuting, Wang Jigang, Liu Yanqin, Tong Danjiang, Liu Jinghua, Zhou Fan |
| collection | DOAJ |
| description | Objective To investigate the significance of metabolic parameters and biochemical indexes of 18F-FDG-PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma （DLBCL）. Methods Clinical data of 194 patients with DLBCL were analyzed retrospectively. The mid-term evaluation results were recorded. The proportion of patients who achieved complete remission （CR） was statistically compared among different clinical indexes（β2-microglobulin （β2-MG）, dual expression, triple expression, Ann Arbor stage, international prognostic index （IPI） and Deauville 5-point scale （D5PS） score） and metabolic parameters of 18F-FDG-PET/CT （the maximum standardized uptake value （SUVmax）, the sum of the maximum standardized uptake value （SUVmaxsum）, the mean standardized uptake value （SUVmean） and the maximum decrease range of SUV （△SUVmax））. The influence of metabolic parameters and biochemical indexes of18F-FDG-PET/CT on the 2-year progression-free survival （PFS） was evaluated by Cox regression models and Kaplan-Meier survival analysis. The correlation between SUVmax and β2-MG, Ann Arbor stage and IPI score was analyzed. Results The proportion of patients with β2-MG > 2.3 mg/L, Ann Arbor stage Ⅲ/Ⅳ, IPI score > 2, SUVmax > 17.00 and SUVmaxsum > 38.60 who achieved CR was significantly decreased, the △SUVmax of patients achieving CR was significantly higher than that of those without CR（all P < 0.05）. Univariate Cox regression analysis showed that β2-MG, Ann Arbor stage, IPI score, dual expression, triple expression, SUVmaxsum and D5PS socre were significantly correlated with the 2-year PFS of DLBCL patients （all P < 0.05）. Multivariate analysis showed that Ann Arbor stage Ⅲ/Ⅳ （HR = 4.486, P = 0.001） was an independent risk factor for the 2-year PFS, and D5PS score of 1-3 （HR = 0.256, P < 0.001） was an independent protective factor for the 2-year PFS of patients with DLBCL. Spearman’s rank correlation analysis demonstrated that SUVmax was significantly associated with β2-MG （rs = 0.348, P = 0.001）, Ann Arbor stage （rs = 0.236, P = 0.022） and IPI score （rs = 0.305, P = 0.003）. Conclusions The metabolic parameters of18F-FDG-PET/CT are associated with clinical indexes. Ann Arbor stage and D5PS can be utilized as reference indexes for clinical prognosis of DLBCL patients. |
| first_indexed | 2024-04-11T07:47:33Z |
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| id | doaj.art-c13d9d3685074065891a0323736b5ab7 |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-11T07:47:33Z |
| publishDate | 2022-03-01 |
| publisher | Editorial Office of Journal of New Medicine |
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| series | Xin yixue |
| spelling | doaj.art-c13d9d3685074065891a0323736b5ab72022-12-22T04:36:14ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-03-0153319920310.3969/j.issn.0253-9802.2022.03.010Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphomaZhang Fan, Zhang Guoxu, Liu Xiuting, Wang Jigang, Liu Yanqin, Tong Danjiang, Liu Jinghua, Zhou Fan0The Graduate Training Base of the Northern Theater General Hospital of Jinzhou Medical University, Shenyang 110016, ChinaObjective To investigate the significance of metabolic parameters and biochemical indexes of 18F-FDG-PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma （DLBCL）. Methods Clinical data of 194 patients with DLBCL were analyzed retrospectively. The mid-term evaluation results were recorded. The proportion of patients who achieved complete remission （CR） was statistically compared among different clinical indexes（β2-microglobulin （β2-MG）, dual expression, triple expression, Ann Arbor stage, international prognostic index （IPI） and Deauville 5-point scale （D5PS） score） and metabolic parameters of 18F-FDG-PET/CT （the maximum standardized uptake value （SUVmax）, the sum of the maximum standardized uptake value （SUVmaxsum）, the mean standardized uptake value （SUVmean） and the maximum decrease range of SUV （△SUVmax））. The influence of metabolic parameters and biochemical indexes of18F-FDG-PET/CT on the 2-year progression-free survival （PFS） was evaluated by Cox regression models and Kaplan-Meier survival analysis. The correlation between SUVmax and β2-MG, Ann Arbor stage and IPI score was analyzed. Results The proportion of patients with β2-MG > 2.3 mg/L, Ann Arbor stage Ⅲ/Ⅳ, IPI score > 2, SUVmax > 17.00 and SUVmaxsum > 38.60 who achieved CR was significantly decreased, the △SUVmax of patients achieving CR was significantly higher than that of those without CR（all P < 0.05）. Univariate Cox regression analysis showed that β2-MG, Ann Arbor stage, IPI score, dual expression, triple expression, SUVmaxsum and D5PS socre were significantly correlated with the 2-year PFS of DLBCL patients （all P < 0.05）. Multivariate analysis showed that Ann Arbor stage Ⅲ/Ⅳ （HR = 4.486, P = 0.001） was an independent risk factor for the 2-year PFS, and D5PS score of 1-3 （HR = 0.256, P < 0.001） was an independent protective factor for the 2-year PFS of patients with DLBCL. Spearman’s rank correlation analysis demonstrated that SUVmax was significantly associated with β2-MG （rs = 0.348, P = 0.001）, Ann Arbor stage （rs = 0.236, P = 0.022） and IPI score （rs = 0.305, P = 0.003）. Conclusions The metabolic parameters of18F-FDG-PET/CT are associated with clinical indexes. Ann Arbor stage and D5PS can be utilized as reference indexes for clinical prognosis of DLBCL patients.https://www.xinyixue.cn/fileup/0253-9802/PDF/1648889513501-1177169121.pdf|fdg pet/ct|dlbcl|suvmax|suvmaxsum|d5ps |
| spellingShingle | Zhang Fan, Zhang Guoxu, Liu Xiuting, Wang Jigang, Liu Yanqin, Tong Danjiang, Liu Jinghua, Zhou Fan Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma Xin yixue |fdg pet/ct|dlbcl|suvmax|suvmaxsum|d5ps |
| title | Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma |
| title_full | Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma |
| title_fullStr | Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma |
| title_full_unstemmed | Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma |
| title_short | Significance of metabolic parameters and biochemical indexes of 18F-FDG PET/CT in the mid-term evaluation and prognosis of diffuse large B-cell lymphoma |
| title_sort | significance of metabolic parameters and biochemical indexes of 18f fdg pet ct in the mid term evaluation and prognosis of diffuse large b cell lymphoma |
| topic | |fdg pet/ct|dlbcl|suvmax|suvmaxsum|d5ps |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1648889513501-1177169121.pdf |
| work_keys_str_mv | AT zhangfanzhangguoxuliuxiutingwangjigangliuyanqintongdanjiangliujinghuazhoufan significanceofmetabolicparametersandbiochemicalindexesof18ffdgpetctinthemidtermevaluationandprognosisofdiffuselargebcelllymphoma |