Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines
Highly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined b...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2011-05-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/16/5/3778/ |
| _version_ | 1819149213698621440 |
|---|---|
| author | Tai-Ran Kang Sha-Sha Kan Jian-Zhen Li Cheng-Yan Ni Quan-Zhong Liu |
| author_facet | Tai-Ran Kang Sha-Sha Kan Jian-Zhen Li Cheng-Yan Ni Quan-Zhong Liu |
| author_sort | Tai-Ran Kang |
| collection | DOAJ |
| description | Highly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined by X-ray analysis. A variety of substrates were tolerable in the present catalytic system. |
| first_indexed | 2024-12-22T13:58:02Z |
| format | Article |
| id | doaj.art-c13e05b6de3c45b092e79c9e553569fd |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T13:58:02Z |
| publishDate | 2011-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-c13e05b6de3c45b092e79c9e553569fd2022-12-21T18:23:30ZengMDPI AGMolecules1420-30492011-05-011653778378610.3390/molecules16053778Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral DiaminesTai-Ran KangSha-Sha KanJian-Zhen LiCheng-Yan NiQuan-Zhong LiuHighly efficient asymmetric aldol reactions between α,β-unsaturated keto esters and acyclic ketones catalyzed by chiral diamines are reported. The corresponding products were obtained in excellent yields with excellent enantioselectivities. The absolute configuration for the product was determined by X-ray analysis. A variety of substrates were tolerable in the present catalytic system.http://www.mdpi.com/1420-3049/16/5/3778/chiral diamineenantioselectivityaldol reactionconfiguration |
| spellingShingle | Tai-Ran Kang Sha-Sha Kan Jian-Zhen Li Cheng-Yan Ni Quan-Zhong Liu Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines Molecules chiral diamine enantioselectivity aldol reaction configuration |
| title | Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines |
| title_full | Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines |
| title_fullStr | Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines |
| title_full_unstemmed | Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines |
| title_short | Asymmetric Aldol Reactions of α,β-Unsaturated Ketoester Substrates Catalyzed by Chiral Diamines |
| title_sort | asymmetric aldol reactions of α β unsaturated ketoester substrates catalyzed by chiral diamines |
| topic | chiral diamine enantioselectivity aldol reaction configuration |
| url | http://www.mdpi.com/1420-3049/16/5/3778/ |
| work_keys_str_mv | AT tairankang asymmetricaldolreactionsofabunsaturatedketoestersubstratescatalyzedbychiraldiamines AT shashakan asymmetricaldolreactionsofabunsaturatedketoestersubstratescatalyzedbychiraldiamines AT jianzhenli asymmetricaldolreactionsofabunsaturatedketoestersubstratescatalyzedbychiraldiamines AT chengyanni asymmetricaldolreactionsofabunsaturatedketoestersubstratescatalyzedbychiraldiamines AT quanzhongliu asymmetricaldolreactionsofabunsaturatedketoestersubstratescatalyzedbychiraldiamines |