Glt25d2 Knockout Directly Increases CD25+CD69– but Decreases CD25–CD69+ Subset Proliferation and is Involved in Concanavalin-Induced Hepatitis

Glt25d2 Knockout Directly Increases CD25+CD69– but Decreases CD25–CD69+ Subset Proliferation and is Involved in Concanavalin-Induced Hepatitis

Background/Aims: The elaborate structure of the extracellular matrix (ECM) and the appropriate surface glycoforms upon it are indispensable to CD4+ T cell regulation. Methods: To explore the effects of Glcα1,2Galβ1 glycosylation mediated by GLT25D2 (Colgalt2) for CD4+ T cell regulation, we prepared...

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Bibliografiske detaljer
Main Authors: Xiaohua Hao, Ran Liu, Yifan Zhang, Yufeng Li, Qun He, Yubo Huang, Yu Jiang, Jiali Ma, Ping Li, Hongshan Wei
Format: Article
Sprog:English
Udgivet: Cell Physiol Biochem Press GmbH & Co KG 2018-10-01
Serier:Cellular Physiology and Biochemistry
Fag:
CD4+ T lymphocyte
Glycosylation
Proliferation
GLT25D2
Gene knockout
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