Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra
Abstract The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of L. paracasei HP7, which has been reported to exert antibacterial and gastri...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | Laboratory Animal Research |
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| Online Access: | http://link.springer.com/article/10.1186/s42826-020-00073-x |
| _version_ | 1819014761674702848 |
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| author | Hyun-A Lee Joo-Yun Kim Jisoo Kim Bora Nam Okjin Kim |
| author_facet | Hyun-A Lee Joo-Yun Kim Jisoo Kim Bora Nam Okjin Kim |
| author_sort | Hyun-A Lee |
| collection | DOAJ |
| description | Abstract The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of L. paracasei HP7, which has been reported to exert antibacterial and gastric mucosal protective effects, in combination with Perilla frutescens var. acuta (P. frutescens)and Glycyrrhiza glabra (G. glabra) extracts. P. frutescens extract and G. glabra extract were found to inhibit the growth of H. pylori in a concentration-dependent manner, and the combination of L. paracasei HP7 and P. frutescens extract and G. glabra extract effectively inhibited H. pylori from attaching to AGS a gastric epithelial cells. Moreover, L. paracasei HP7 complex mixture containing P. frutescens and G. glabra extracts has been shown to inhibit H. pylori virulence genes such as AlpA, CagA, FlaA and UreA. When H. pylori-infected mice were administered a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extract, the infection rate of H. pylori was significantly reduced. In addition, the L. paracasei HP7 complex mixture significantly reduced serum IL-8 levels and stomach inflammation in H. pylori infected mice. These results suggest that a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extracts may be an alternative to treating diseases caused by H. pylori infection. |
| first_indexed | 2024-12-21T02:20:59Z |
| format | Article |
| id | doaj.art-c1415f026f9a407094bf60b1db38661a |
| institution | Directory Open Access Journal |
| issn | 2233-7660 |
| language | English |
| last_indexed | 2024-12-21T02:20:59Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Laboratory Animal Research |
| spelling | doaj.art-c1415f026f9a407094bf60b1db38661a2022-12-21T19:19:08ZengBMCLaboratory Animal Research2233-76602020-10-013611810.1186/s42826-020-00073-xAnti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabraHyun-A Lee0Joo-Yun Kim1Jisoo Kim2Bora Nam3Okjin Kim4Center for Animal Resources Development, Wonkwang UniversityR&BD Center, Korea Yakult Co., Ltd.R&BD Center, Korea Yakult Co., Ltd.R&BD Center, Korea Yakult Co., Ltd.Center for Animal Resources Development, Wonkwang UniversityAbstract The effect of standard therapeutic strategies on Helicobacter pylori infection is diminished over time owing to the emergence of drug resistant strains. In this study, we would like to confirm the enhanced effect of L. paracasei HP7, which has been reported to exert antibacterial and gastric mucosal protective effects, in combination with Perilla frutescens var. acuta (P. frutescens)and Glycyrrhiza glabra (G. glabra) extracts. P. frutescens extract and G. glabra extract were found to inhibit the growth of H. pylori in a concentration-dependent manner, and the combination of L. paracasei HP7 and P. frutescens extract and G. glabra extract effectively inhibited H. pylori from attaching to AGS a gastric epithelial cells. Moreover, L. paracasei HP7 complex mixture containing P. frutescens and G. glabra extracts has been shown to inhibit H. pylori virulence genes such as AlpA, CagA, FlaA and UreA. When H. pylori-infected mice were administered a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extract, the infection rate of H. pylori was significantly reduced. In addition, the L. paracasei HP7 complex mixture significantly reduced serum IL-8 levels and stomach inflammation in H. pylori infected mice. These results suggest that a complex mixture of L. paracasei HP7 containing P. frutescens and G. glabra extracts may be an alternative to treating diseases caused by H. pylori infection.http://link.springer.com/article/10.1186/s42826-020-00073-xLactobacillus paracaseiHP7Helicobacter pyloriPerilla frutescens var. acutaGlycyrrhiza glabr |
| spellingShingle | Hyun-A Lee Joo-Yun Kim Jisoo Kim Bora Nam Okjin Kim Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra Laboratory Animal Research Lactobacillus paracasei HP7 Helicobacter pylori Perilla frutescens var. acuta Glycyrrhiza glabr |
| title | Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra |
| title_full | Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra |
| title_fullStr | Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra |
| title_full_unstemmed | Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra |
| title_short | Anti-Helicobacter pylori activity of acomplex mixture of Lactobacillus paracasei HP7 including the extract of Perilla frutescens var. acuta and Glycyrrhiza glabra |
| title_sort | anti helicobacter pylori activity of acomplex mixture of lactobacillus paracasei hp7 including the extract of perilla frutescens var acuta and glycyrrhiza glabra |
| topic | Lactobacillus paracasei HP7 Helicobacter pylori Perilla frutescens var. acuta Glycyrrhiza glabr |
| url | http://link.springer.com/article/10.1186/s42826-020-00073-x |
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