An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation
Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose and lipid metabolism, favoring the development of degenerative diseases, including type II diabetes. Congruently, the inflammatory signaling inhibition prevents the deve...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2022-06-01
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| Series: | Disease Models & Mechanisms |
| Subjects: | |
| Online Access: | http://dmm.biologists.org/content/15/6/dmm048936 |
| _version_ | 1811293662486724608 |
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| author | Sol Díaz de León-Guerrero Jonathan Salazar-León Karla F. Meza-Sosa David Valle-Garcia Diana Aguilar-León Gustavo Pedraza-Alva Leonor Pérez-Martínez |
| author_facet | Sol Díaz de León-Guerrero Jonathan Salazar-León Karla F. Meza-Sosa David Valle-Garcia Diana Aguilar-León Gustavo Pedraza-Alva Leonor Pérez-Martínez |
| author_sort | Sol Díaz de León-Guerrero |
| collection | DOAJ |
| description | Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose and lipid metabolism, favoring the development of degenerative diseases, including type II diabetes. Congruently, the inflammatory signaling inhibition prevents the development of obesity and restores insulin sensitivity. Via the enhancement of central nervous system activity, an enriched environment (EE) has beneficial effects on learning and memory as well as on immune cell functions and inflammation in different disease models. Here, we explored whether an EE can restore energy balance in obese mice that previously presented metabolic alterations. We discovered that an EE improved glucose metabolism, increased insulin signaling in liver, and reduced hepatic steatosis and inflammation, and increased lipolysis and browning in the white adipose tissue of high-fat diet (HFD)-fed mice. Finally, we found reduced inflammatory signaling and increased anorexigenic signaling in the hypothalamus of HFD-fed mice exposed to an EE. These data indicate that an EE is able to restore the metabolic imbalance caused by HFD feeding. Thus, we propose EE as a novel therapeutic approach for treating obesity-related metabolic alterations. This article has an associated First Person interview with the first author of the paper. |
| first_indexed | 2024-04-13T05:04:49Z |
| format | Article |
| id | doaj.art-c141ede2316644e986d54401b8bda206 |
| institution | Directory Open Access Journal |
| issn | 1754-8403 1754-8411 |
| language | English |
| last_indexed | 2024-04-13T05:04:49Z |
| publishDate | 2022-06-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj.art-c141ede2316644e986d54401b8bda2062022-12-22T03:01:13ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112022-06-0115610.1242/dmm.048936048936An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammationSol Díaz de León-Guerrero0Jonathan Salazar-León1Karla F. Meza-Sosa2David Valle-Garcia3Diana Aguilar-León4Gustavo Pedraza-Alva5Leonor Pérez-Martínez6 Laboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, CP 62210, Mexico Laboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, CP 62210, Mexico Laboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, CP 62210, Mexico Laboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, CP 62210, Mexico Departamento de Patología, Instituto Nacional de Ciencias Médicas y Nutrición ‘Salvador Zubirán’, Tlalpan, Ciudad de México, CP 14000, Mexico Laboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, CP 62210, Mexico Laboratorio de Neuroinmunobiología, Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Cuernavaca, Morelos, CP 62210, Mexico Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose and lipid metabolism, favoring the development of degenerative diseases, including type II diabetes. Congruently, the inflammatory signaling inhibition prevents the development of obesity and restores insulin sensitivity. Via the enhancement of central nervous system activity, an enriched environment (EE) has beneficial effects on learning and memory as well as on immune cell functions and inflammation in different disease models. Here, we explored whether an EE can restore energy balance in obese mice that previously presented metabolic alterations. We discovered that an EE improved glucose metabolism, increased insulin signaling in liver, and reduced hepatic steatosis and inflammation, and increased lipolysis and browning in the white adipose tissue of high-fat diet (HFD)-fed mice. Finally, we found reduced inflammatory signaling and increased anorexigenic signaling in the hypothalamus of HFD-fed mice exposed to an EE. These data indicate that an EE is able to restore the metabolic imbalance caused by HFD feeding. Thus, we propose EE as a novel therapeutic approach for treating obesity-related metabolic alterations. This article has an associated First Person interview with the first author of the paper.http://dmm.biologists.org/content/15/6/dmm048936obesityenriched environmentinflammationmetabolism |
| spellingShingle | Sol Díaz de León-Guerrero Jonathan Salazar-León Karla F. Meza-Sosa David Valle-Garcia Diana Aguilar-León Gustavo Pedraza-Alva Leonor Pérez-Martínez An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation Disease Models & Mechanisms obesity enriched environment inflammation metabolism |
| title | An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation |
| title_full | An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation |
| title_fullStr | An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation |
| title_full_unstemmed | An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation |
| title_short | An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation |
| title_sort | enriched environment re establishes metabolic homeostasis by reducing obesity induced inflammation |
| topic | obesity enriched environment inflammation metabolism |
| url | http://dmm.biologists.org/content/15/6/dmm048936 |
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