Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review
Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Althou...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Bashkir State Medical University
2022-07-01
|
| Series: | Креативная хирургия и онкология |
| Subjects: | |
| Online Access: | https://www.surgonco.ru/jour/article/view/695 |
| _version_ | 1826532762220232704 |
|---|---|
| author | K. V. Menshikov A. V. Sultanbaev Sh. I. Musin I. R. Rakhmatullina I. A. Menshikova R. R. Abdeev N. I. Sultanbaeva E. V. Popova G. A. Serebrennikov |
| author_facet | K. V. Menshikov A. V. Sultanbaev Sh. I. Musin I. R. Rakhmatullina I. A. Menshikova R. R. Abdeev N. I. Sultanbaeva E. V. Popova G. A. Serebrennikov |
| author_sort | K. V. Menshikov |
| collection | DOAJ |
| description | Liver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field. |
| first_indexed | 2024-04-10T00:58:55Z |
| format | Article |
| id | doaj.art-c14b45b6db8241569154b21ca73ae506 |
| institution | Directory Open Access Journal |
| issn | 2076-3093 2307-0501 |
| language | English |
| last_indexed | 2025-03-14T01:56:23Z |
| publishDate | 2022-07-01 |
| publisher | Bashkir State Medical University |
| record_format | Article |
| series | Креативная хирургия и онкология |
| spelling | doaj.art-c14b45b6db8241569154b21ca73ae5062025-03-12T07:05:52ZengBashkir State Medical UniversityКреативная хирургия и онкология2076-30932307-05012022-07-0112213915010.24060/2076-3093-2022-12-2-139-150478Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature ReviewK. V. Menshikov0A. V. Sultanbaev1Sh. I. Musin2I. R. Rakhmatullina3I. A. Menshikova4R. R. Abdeev5N. I. Sultanbaeva6E. V. Popova7G. A. Serebrennikov8Republican Clinical Oncology Dispensary; Bashkir State Medical UniversityRepublican Clinical Oncology DispensaryRepublican Clinical Oncology DispensaryBashkir State Medical UniversityBashkir State Medical UniversityRepublican Clinical Oncology DispensaryRepublican Clinical Oncology DispensaryRepublican Clinical Oncology DispensaryBashkir State Medical UniversityLiver cancer remains a global challenge of healthcare, with the incidence growing worldwide. According to various authors, over 1 million patients will be diagnosed with liver cancer each year by 2025. The molecular pathogenesis of HCC varies with respect to genotoxic lesions and aetiologies. Although our understanding of the HCC pathophysiology and drivers tends to improve, it is still distant from translation into clinical practice. About 25 % of HCC cases are associated with variant mutations. HCC pathophysiology is a complex multi-step process. The interaction of various factors underlies the early stages of malignant hepatocyte transformation towards the development of HCC. Overall, about 20–25 % of HCC patients have at least one potential driver mutation. Obesity should also be noted as being associated with a higher risk of HCC and various other cancers. Despite many issues in the HCC pathogenesis being already known, the unresolved questions remain. Modern molecular genetic diagnostics and animal modelling of malignant tumours are expanding our horizons of knowledge in this field.https://www.surgonco.ru/jour/article/view/695hepatocellular carcinomaliver cancermolecular pathogenesisdriver mutationstumour microenvironmentnon-alcoholic steatohepatitisviral hepatitis |
| spellingShingle | K. V. Menshikov A. V. Sultanbaev Sh. I. Musin I. R. Rakhmatullina I. A. Menshikova R. R. Abdeev N. I. Sultanbaeva E. V. Popova G. A. Serebrennikov Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review Креативная хирургия и онкология hepatocellular carcinoma liver cancer molecular pathogenesis driver mutations tumour microenvironment non-alcoholic steatohepatitis viral hepatitis |
| title | Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review |
| title_full | Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review |
| title_fullStr | Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review |
| title_full_unstemmed | Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review |
| title_short | Hepatocellular Carcinoma: Aetiology and Mechanisms of Development. A Literature Review |
| title_sort | hepatocellular carcinoma aetiology and mechanisms of development a literature review |
| topic | hepatocellular carcinoma liver cancer molecular pathogenesis driver mutations tumour microenvironment non-alcoholic steatohepatitis viral hepatitis |
| url | https://www.surgonco.ru/jour/article/view/695 |
| work_keys_str_mv | AT kvmenshikov hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT avsultanbaev hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT shimusin hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT irrakhmatullina hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT iamenshikova hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT rrabdeev hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT nisultanbaeva hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT evpopova hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview AT gaserebrennikov hepatocellularcarcinomaaetiologyandmechanismsofdevelopmentaliteraturereview |