The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma?
<p>Abstract</p> <p>Background</p> <p>This study aims to analyze the structure and quantities of cellular elements in sarcoid granulomas.</p> <p>Methods</p> <p>We investigated 34 transbronchial lung biopsy samples obtained from 34 sarcoid patients...
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| Format: | Article |
| Language: | English |
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Mattioli 1885
2012-06-01
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| Series: | Multidisciplinary Respiratory Medicine |
| Subjects: | |
| Online Access: | http://www.mrmjournal.com/content/7/1/11 |
| _version_ | 1827263903642419200 |
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| author | Kosjerina Zdravko Zaric Bojan Vuckovic Dejan Lalosevic Dusan Djenadic Goran Murer Bruno |
| author_facet | Kosjerina Zdravko Zaric Bojan Vuckovic Dejan Lalosevic Dusan Djenadic Goran Murer Bruno |
| author_sort | Kosjerina Zdravko |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>This study aims to analyze the structure and quantities of cellular elements in sarcoid granulomas.</p> <p>Methods</p> <p>We investigated 34 transbronchial lung biopsy samples obtained from 34 sarcoid patients. The quantity and composition of the cellular elements inside a granuloma were determined by the quantitative stereometry method, employing the numerical density as a stereological method.</p> <p>Results</p> <p>A total of 102 sarcoid granulomas were analyzed. The central part of all granulomas was occupied by epithelioid cells. Besides these, giant cells, lymphocytes, macrophages and plasma cells were also seen. The mean numerical density of all the cells in the central part of a sarcoid granuloma was 111,751 mm<sup>-3.</sup> Lymphocytes prevailed in number, exceeding the total count of all other cells. With a mean numerical density of 74,321 mm<sup>-3</sup>, lymphocytes were twice as numerous as both epithelioid cells and macrophages with a mean numerical density of 37,193 mm<sup>-3</sup>.</p> <p>Conclusions</p> <p>Lymphocytes are the predominant cell type in the central part of a sarcoid granuloma, significantly exceeding both epithelioid cells and macrophages in number, raising the question if the term “epithelioid granuloma”, routinely used to designate sarcoid granulomas, is correct, or if it would be more logical to call them “lymphocytic-epithelioid granulomas” instead.</p> <p>Trial registration</p> <p>This study was supported by the Serbian Ministry of Science and Environmental Protection Grant Number 175006/2011.</p> |
| first_indexed | 2024-03-07T17:20:25Z |
| format | Article |
| id | doaj.art-c14c17e4a1f2412198b76eeeb73dad2d |
| institution | Directory Open Access Journal |
| issn | 2049-6958 |
| language | English |
| last_indexed | 2025-03-22T03:37:34Z |
| publishDate | 2012-06-01 |
| publisher | Mattioli 1885 |
| record_format | Article |
| series | Multidisciplinary Respiratory Medicine |
| spelling | doaj.art-c14c17e4a1f2412198b76eeeb73dad2d2024-04-28T12:09:55ZengMattioli 1885Multidisciplinary Respiratory Medicine2049-69582012-06-01711110.1186/2049-6958-7-11The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma?Kosjerina ZdravkoZaric BojanVuckovic DejanLalosevic DusanDjenadic GoranMurer Bruno<p>Abstract</p> <p>Background</p> <p>This study aims to analyze the structure and quantities of cellular elements in sarcoid granulomas.</p> <p>Methods</p> <p>We investigated 34 transbronchial lung biopsy samples obtained from 34 sarcoid patients. The quantity and composition of the cellular elements inside a granuloma were determined by the quantitative stereometry method, employing the numerical density as a stereological method.</p> <p>Results</p> <p>A total of 102 sarcoid granulomas were analyzed. The central part of all granulomas was occupied by epithelioid cells. Besides these, giant cells, lymphocytes, macrophages and plasma cells were also seen. The mean numerical density of all the cells in the central part of a sarcoid granuloma was 111,751 mm<sup>-3.</sup> Lymphocytes prevailed in number, exceeding the total count of all other cells. With a mean numerical density of 74,321 mm<sup>-3</sup>, lymphocytes were twice as numerous as both epithelioid cells and macrophages with a mean numerical density of 37,193 mm<sup>-3</sup>.</p> <p>Conclusions</p> <p>Lymphocytes are the predominant cell type in the central part of a sarcoid granuloma, significantly exceeding both epithelioid cells and macrophages in number, raising the question if the term “epithelioid granuloma”, routinely used to designate sarcoid granulomas, is correct, or if it would be more logical to call them “lymphocytic-epithelioid granulomas” instead.</p> <p>Trial registration</p> <p>This study was supported by the Serbian Ministry of Science and Environmental Protection Grant Number 175006/2011.</p>http://www.mrmjournal.com/content/7/1/11Epithelioid granulomaLymphocytic-epithelioid granulomaMorphometrySarcoidosis |
| spellingShingle | Kosjerina Zdravko Zaric Bojan Vuckovic Dejan Lalosevic Dusan Djenadic Goran Murer Bruno The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma? Multidisciplinary Respiratory Medicine Epithelioid granuloma Lymphocytic-epithelioid granuloma Morphometry Sarcoidosis |
| title | The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma? |
| title_full | The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma? |
| title_fullStr | The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma? |
| title_full_unstemmed | The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma? |
| title_short | The sarcoid granuloma: ‘epithelioid’ or ‘lymphocytic-epithelioid’ granuloma? |
| title_sort | sarcoid granuloma epithelioid or lymphocytic epithelioid granuloma |
| topic | Epithelioid granuloma Lymphocytic-epithelioid granuloma Morphometry Sarcoidosis |
| url | http://www.mrmjournal.com/content/7/1/11 |
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