Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic
In this study we evaluated the possible teratogenic effects of arsenic (As) in the same concentrations recorded in water Zimapan, Hidalgo, using specimens of Rattus norvegicus Wistar strain, pregnant. Were subjected to varying concentrations of sodium arsenate (1887.9 mg/L, 943.9 mg/L and 0.5 mg/L),...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2018-07-01
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| Series: | Dyna |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/dyna/article/view/68670 |
| _version_ | 1819088909109297152 |
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| author | Mireya Quiterio-Pérez Juan Carlos Gaytán-Oyarzún Alberto José Gordillo-Martínez Francisco Prieto-García |
| author_facet | Mireya Quiterio-Pérez Juan Carlos Gaytán-Oyarzún Alberto José Gordillo-Martínez Francisco Prieto-García |
| author_sort | Mireya Quiterio-Pérez |
| collection | DOAJ |
| description | In this study we evaluated the possible teratogenic effects of arsenic (As) in the same concentrations recorded in water Zimapan, Hidalgo, using specimens of Rattus norvegicus Wistar strain, pregnant. Were subjected to varying concentrations of sodium arsenate (1887.9 mg/L, 943.9 mg/L and 0.5 mg/L), concentration, 0.5 mg/L corresponds to the registered Zimapan water, Hidalgo and chromium trioxide (166.0 mg/L) used as positive control and 5% sucrose as a negative control. The specimens were exposed from day 7 through 15 of gestation, and were sacrificed on day 19 of gestation by inhalation of chloroform. We analyzed reproductive harm the mother, as well as alterations and lack of ossification of the bone tissue of the fetus. The highest dose tested (1887.9 mg/L) produced more reproductive harm in mother resorptions caused by preventing the continuation of embryonic development. Concentrations of 0.5 mg/L to 943.9 mg/L, resulted in lack of ossification ribs, sternebrae, metacarpals, phalanges previous metatarsals and phalanges posterior sacral vertebrae. |
| first_indexed | 2024-12-21T21:59:31Z |
| format | Article |
| id | doaj.art-c152bfc8eeb345ea9bf418dd66beabf1 |
| institution | Directory Open Access Journal |
| issn | 0012-7353 2346-2183 |
| language | English |
| last_indexed | 2024-12-21T21:59:31Z |
| publishDate | 2018-07-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Dyna |
| spelling | doaj.art-c152bfc8eeb345ea9bf418dd66beabf12022-12-21T18:48:51ZengUniversidad Nacional de ColombiaDyna0012-73532346-21832018-07-018520624224910.15446/dyna.v85n206.6867049205Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenicMireya Quiterio-Pérez0Juan Carlos Gaytán-Oyarzún1Alberto José Gordillo-Martínez2Francisco Prieto-García3Universidad Autónoma del Estado de HidalgoUniversidad Autónoma del Estado de HidalgoUniversidad Autónoma del Estado de HidalgoUniversidad Autónoma del Estado de HidalgoIn this study we evaluated the possible teratogenic effects of arsenic (As) in the same concentrations recorded in water Zimapan, Hidalgo, using specimens of Rattus norvegicus Wistar strain, pregnant. Were subjected to varying concentrations of sodium arsenate (1887.9 mg/L, 943.9 mg/L and 0.5 mg/L), concentration, 0.5 mg/L corresponds to the registered Zimapan water, Hidalgo and chromium trioxide (166.0 mg/L) used as positive control and 5% sucrose as a negative control. The specimens were exposed from day 7 through 15 of gestation, and were sacrificed on day 19 of gestation by inhalation of chloroform. We analyzed reproductive harm the mother, as well as alterations and lack of ossification of the bone tissue of the fetus. The highest dose tested (1887.9 mg/L) produced more reproductive harm in mother resorptions caused by preventing the continuation of embryonic development. Concentrations of 0.5 mg/L to 943.9 mg/L, resulted in lack of ossification ribs, sternebrae, metacarpals, phalanges previous metatarsals and phalanges posterior sacral vertebrae.https://revistas.unal.edu.co/index.php/dyna/article/view/68670sodium arsenateteratogenicreproductive harmlack of ossificationRattus norvegicus |
| spellingShingle | Mireya Quiterio-Pérez Juan Carlos Gaytán-Oyarzún Alberto José Gordillo-Martínez Francisco Prieto-García Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic Dyna sodium arsenate teratogenic reproductive harm lack of ossification Rattus norvegicus |
| title | Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic |
| title_full | Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic |
| title_fullStr | Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic |
| title_full_unstemmed | Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic |
| title_short | Teratogenic effect on bone tissue development in Rattus norvegicus Wistar strain, induced by the presence of arsenic |
| title_sort | teratogenic effect on bone tissue development in rattus norvegicus wistar strain induced by the presence of arsenic |
| topic | sodium arsenate teratogenic reproductive harm lack of ossification Rattus norvegicus |
| url | https://revistas.unal.edu.co/index.php/dyna/article/view/68670 |
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