Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects
Solanum xanthocarpum is used for the treatment of rheumatic arthritis, toothache, sore throats, carbuncle, furuncle, and other inflammatory diseases in traditional Chinese medicine and Ayurvedic medical system, with the phenolic compounds being one of its principal components. In this study, 51 phen...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Arabian Journal of Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535222001939 |
| _version_ | 1818531057090166784 |
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| author | Zhen-Peng Xu Yan Liu Si-Yi Wang Zi-Wei Li Dong-Xu Lu Peng Jiang Juan Pan Wei Guan Hai-Xue Kuang Bing-You Yang |
| author_facet | Zhen-Peng Xu Yan Liu Si-Yi Wang Zi-Wei Li Dong-Xu Lu Peng Jiang Juan Pan Wei Guan Hai-Xue Kuang Bing-You Yang |
| author_sort | Zhen-Peng Xu |
| collection | DOAJ |
| description | Solanum xanthocarpum is used for the treatment of rheumatic arthritis, toothache, sore throats, carbuncle, furuncle, and other inflammatory diseases in traditional Chinese medicine and Ayurvedic medical system, with the phenolic compounds being one of its principal components. In this study, 51 phenolic compounds including seven new compounds 1, 2, 9, 13, 17, 22, and 40 were isolated from the fruits of Solanum xanthocarpum. 40 known compounds 3–8, 10–12, 14–16, 18–21, 23–25, 28–32, 35–39, 41–51 were firstly isolated from Solanum xanthocarpum. Their structures were determined by comprehensive spectroscopic analyses, X-ray crystallography, NMR calculations, chemical methods, and comparisons of spectroscopic data. The results of anti-inflammatory assays indicated that most isolated compounds (3–7, 11–30, 32–37, 39, 40, 42, 43, 45, and 48–51) possessed significant inhibitory activities of the NO release of LPS-induced RAW 264.7 cells, with IC50 values ranging from 10.46 to 47.59 μM. Further analysis by molecular docking implied that most bioactive compounds could interact with the amino acid residues of iNOS proteins, supporting the anti-inflammatory activity of the compounds. Especially, compounds 17–20, 26–27, 32, and 34 showed strong affinities with iNOS proteins. The bioinformatic analysis further revealed the potential anti-inflammatory targets of the phenolic compounds isolated from the fruits of Solanum xanthocarpum. |
| first_indexed | 2024-12-11T17:27:32Z |
| format | Article |
| id | doaj.art-c1539412e2b7464eb8683bc5cef0675d |
| institution | Directory Open Access Journal |
| issn | 1878-5352 |
| language | English |
| last_indexed | 2024-12-11T17:27:32Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arabian Journal of Chemistry |
| spelling | doaj.art-c1539412e2b7464eb8683bc5cef0675d2022-12-22T00:56:56ZengElsevierArabian Journal of Chemistry1878-53522022-07-01157103877Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effectsZhen-Peng Xu0Yan Liu1Si-Yi Wang2Zi-Wei Li3Dong-Xu Lu4Peng Jiang5Juan Pan6Wei Guan7Hai-Xue Kuang8Bing-You Yang9Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaKey Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaCorresponding authors.; Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaCorresponding authors.; Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Heilongjiang University of Chinese Medicine, Harbin 150040, ChinaSolanum xanthocarpum is used for the treatment of rheumatic arthritis, toothache, sore throats, carbuncle, furuncle, and other inflammatory diseases in traditional Chinese medicine and Ayurvedic medical system, with the phenolic compounds being one of its principal components. In this study, 51 phenolic compounds including seven new compounds 1, 2, 9, 13, 17, 22, and 40 were isolated from the fruits of Solanum xanthocarpum. 40 known compounds 3–8, 10–12, 14–16, 18–21, 23–25, 28–32, 35–39, 41–51 were firstly isolated from Solanum xanthocarpum. Their structures were determined by comprehensive spectroscopic analyses, X-ray crystallography, NMR calculations, chemical methods, and comparisons of spectroscopic data. The results of anti-inflammatory assays indicated that most isolated compounds (3–7, 11–30, 32–37, 39, 40, 42, 43, 45, and 48–51) possessed significant inhibitory activities of the NO release of LPS-induced RAW 264.7 cells, with IC50 values ranging from 10.46 to 47.59 μM. Further analysis by molecular docking implied that most bioactive compounds could interact with the amino acid residues of iNOS proteins, supporting the anti-inflammatory activity of the compounds. Especially, compounds 17–20, 26–27, 32, and 34 showed strong affinities with iNOS proteins. The bioinformatic analysis further revealed the potential anti-inflammatory targets of the phenolic compounds isolated from the fruits of Solanum xanthocarpum.http://www.sciencedirect.com/science/article/pii/S1878535222001939Solanum xanthocarpumAnti-inflammatoryNO inhibitory effectsPhenolic compounds |
| spellingShingle | Zhen-Peng Xu Yan Liu Si-Yi Wang Zi-Wei Li Dong-Xu Lu Peng Jiang Juan Pan Wei Guan Hai-Xue Kuang Bing-You Yang Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects Arabian Journal of Chemistry Solanum xanthocarpum Anti-inflammatory NO inhibitory effects Phenolic compounds |
| title | Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects |
| title_full | Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects |
| title_fullStr | Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects |
| title_full_unstemmed | Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects |
| title_short | Phenolic compounds of Solanum xanthocarpum play an important role in anti-inflammatory effects |
| title_sort | phenolic compounds of solanum xanthocarpum play an important role in anti inflammatory effects |
| topic | Solanum xanthocarpum Anti-inflammatory NO inhibitory effects Phenolic compounds |
| url | http://www.sciencedirect.com/science/article/pii/S1878535222001939 |
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