Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus
Preterm contraction of uterus is a main cause of miscarriages and preterm labour. Euphorbia known as Ferphion in Iranian traditional medicine texts like Al-Hawi, is reported for prevention of preterm labour. Therefore, the objective of this research was to investigate the effect of Euphorbia spinide...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Research in Pharmaceutical Sciences |
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| Online Access: | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2016;volume=11;issue=6;spage=491;epage=496;aulast=Ghanadian |
| _version_ | 1819142483508985856 |
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| author | Mustafa Ghanadian Hassan Sadraei Zeinab Cheraghi |
| author_facet | Mustafa Ghanadian Hassan Sadraei Zeinab Cheraghi |
| author_sort | Mustafa Ghanadian |
| collection | DOAJ |
| description | Preterm contraction of uterus is a main cause of miscarriages and preterm labour. Euphorbia known as Ferphion in Iranian traditional medicine texts like Al-Hawi, is reported for prevention of preterm labour. Therefore, the objective of this research was to investigate the effect of Euphorbia spinidens Bornm. Ex Prokh. on motility of rat uterus. Uterine horns were isolated form non-pregnant female rats pretreated with estrogen. E. spinidens hydroalcoholic extract was examined on KCl (80 mM) induced and spontaneous periodic contraction in isolate uterine strips suspended in an organ bath and compared with nifedipine and ritodrine. In isolated rat uterine strips, E. spinidens extract (1-500 µg/mL) showed mixed effects. At lower concentrations, firstly potentiated the spontaneous periodic contraction, while in concentrations above 256 µg/mL the spontaneous periodic contractions were completely attenuated. These findings demonstrated that although lower concentrations of hydroalcoholic extract potentiated the spontaneous periodic contraction of rat uterine smooth muscle, but at higher concentrations it had inhibitory effect on rat uterus contraction. |
| first_indexed | 2024-12-22T12:11:04Z |
| format | Article |
| id | doaj.art-c1554fec0ba74277841df89ed1a1cbbe |
| institution | Directory Open Access Journal |
| issn | 1735-5362 1735-9414 |
| language | English |
| last_indexed | 2024-12-22T12:11:04Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
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| series | Research in Pharmaceutical Sciences |
| spelling | doaj.art-c1554fec0ba74277841df89ed1a1cbbe2022-12-21T18:26:18ZengWolters Kluwer Medknow PublicationsResearch in Pharmaceutical Sciences1735-53621735-94142016-01-0111649149610.4103/1735-5362.194893Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterusMustafa GhanadianHassan SadraeiZeinab CheraghiPreterm contraction of uterus is a main cause of miscarriages and preterm labour. Euphorbia known as Ferphion in Iranian traditional medicine texts like Al-Hawi, is reported for prevention of preterm labour. Therefore, the objective of this research was to investigate the effect of Euphorbia spinidens Bornm. Ex Prokh. on motility of rat uterus. Uterine horns were isolated form non-pregnant female rats pretreated with estrogen. E. spinidens hydroalcoholic extract was examined on KCl (80 mM) induced and spontaneous periodic contraction in isolate uterine strips suspended in an organ bath and compared with nifedipine and ritodrine. In isolated rat uterine strips, E. spinidens extract (1-500 µg/mL) showed mixed effects. At lower concentrations, firstly potentiated the spontaneous periodic contraction, while in concentrations above 256 µg/mL the spontaneous periodic contractions were completely attenuated. These findings demonstrated that although lower concentrations of hydroalcoholic extract potentiated the spontaneous periodic contraction of rat uterine smooth muscle, but at higher concentrations it had inhibitory effect on rat uterus contraction.http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2016;volume=11;issue=6;spage=491;epage=496;aulast=Ghanadianeuphorbia spinidens ; uterus; spasmodic; spasmolytic; kcl |
| spellingShingle | Mustafa Ghanadian Hassan Sadraei Zeinab Cheraghi Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus Research in Pharmaceutical Sciences euphorbia spinidens ; uterus; spasmodic; spasmolytic; kcl |
| title | Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus |
| title_full | Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus |
| title_fullStr | Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus |
| title_full_unstemmed | Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus |
| title_short | Spasmodic versus spasmolytic activities of Euphorbia spinidens extract on rat isolated uterus |
| title_sort | spasmodic versus spasmolytic activities of euphorbia spinidens extract on rat isolated uterus |
| topic | euphorbia spinidens ; uterus; spasmodic; spasmolytic; kcl |
| url | http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2016;volume=11;issue=6;spage=491;epage=496;aulast=Ghanadian |
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