The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications
Abstract Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell microenvironment provides factors and elements that play significant roles in controlling the cell fate direction. The bone marrow is an important environment for functional hematopoietic stem cells in...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-11-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13287-019-1422-7 |
| _version_ | 1818198482845958144 |
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| author | Pan Zhang Chen Zhang Jing Li Jiyang Han Xiru Liu Hui Yang |
| author_facet | Pan Zhang Chen Zhang Jing Li Jiyang Han Xiru Liu Hui Yang |
| author_sort | Pan Zhang |
| collection | DOAJ |
| description | Abstract Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell microenvironment provides factors and elements that play significant roles in controlling the cell fate direction. The bone marrow is an important environment for functional hematopoietic stem cells in adults. Remarkable progress has been achieved in the area of hematopoietic stem cell fate modulation based on the recognition of biochemical factors provided by bone marrow niches. In this review, we focus on emerging evidence that hematopoietic stem cell fate is altered in response to a variety of microenvironmental physical cues, such as geometric properties, matrix stiffness, and mechanical forces. Based on knowledge of these biophysical cues, recent developments in harnessing hematopoietic stem cell niches ex vivo are also discussed. A comprehensive understanding of cell microenvironments helps provide mechanistic insights into pathophysiological mechanisms and underlies biomaterial-based hematopoietic stem cell engineering. |
| first_indexed | 2024-12-12T02:06:35Z |
| format | Article |
| id | doaj.art-c15582f1e6d64f098a8701d4b8edeac2 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-12-12T02:06:35Z |
| publishDate | 2019-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-c15582f1e6d64f098a8701d4b8edeac22022-12-22T00:42:02ZengBMCStem Cell Research & Therapy1757-65122019-11-0110111310.1186/s13287-019-1422-7The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applicationsPan Zhang0Chen Zhang1Jing Li2Jiyang Han3Xiru Liu4Hui Yang5School of Life Sciences, Northwestern Polytechnical UniversitySchool of Life Sciences, Northwestern Polytechnical UniversitySchool of Life Sciences, Northwestern Polytechnical UniversitySchool of Life Sciences, Northwestern Polytechnical UniversitySchool of Life Sciences, Northwestern Polytechnical UniversitySchool of Life Sciences, Northwestern Polytechnical UniversityAbstract Stem cells are considered the fundamental underpinnings of tissue biology. The stem cell microenvironment provides factors and elements that play significant roles in controlling the cell fate direction. The bone marrow is an important environment for functional hematopoietic stem cells in adults. Remarkable progress has been achieved in the area of hematopoietic stem cell fate modulation based on the recognition of biochemical factors provided by bone marrow niches. In this review, we focus on emerging evidence that hematopoietic stem cell fate is altered in response to a variety of microenvironmental physical cues, such as geometric properties, matrix stiffness, and mechanical forces. Based on knowledge of these biophysical cues, recent developments in harnessing hematopoietic stem cell niches ex vivo are also discussed. A comprehensive understanding of cell microenvironments helps provide mechanistic insights into pathophysiological mechanisms and underlies biomaterial-based hematopoietic stem cell engineering.http://link.springer.com/article/10.1186/s13287-019-1422-7Hematopoietic stem cellBone marrow nicheBiophysical signalBiomaterialEngineering |
| spellingShingle | Pan Zhang Chen Zhang Jing Li Jiyang Han Xiru Liu Hui Yang The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications Stem Cell Research & Therapy Hematopoietic stem cell Bone marrow niche Biophysical signal Biomaterial Engineering |
| title | The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications |
| title_full | The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications |
| title_fullStr | The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications |
| title_full_unstemmed | The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications |
| title_short | The physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications |
| title_sort | physical microenvironment of hematopoietic stem cells and its emerging roles in engineering applications |
| topic | Hematopoietic stem cell Bone marrow niche Biophysical signal Biomaterial Engineering |
| url | http://link.springer.com/article/10.1186/s13287-019-1422-7 |
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