The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon
Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic proc...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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Scientific Сentre for Family Health and Human Reproduction Problems
2021-11-01
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| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/3051 |
| _version_ | 1797237225236201472 |
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| author | E. A. Tseimakh V. Yu. Zinchenko |
| author_facet | E. A. Tseimakh V. Yu. Zinchenko |
| author_sort | E. A. Tseimakh |
| collection | DOAJ |
| description | Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic processes are the emerging microcirculation disorders due to the formation of micro-clots. An important point that aggravates the course of the disease is the development of thrombohemorrhagic syndrome. As a result, even with a variety of antibacterial drugs and the ыavailability of new treatment methods, it is often not possible to achieve positive results in the treatment of this heavy contingent of patients.Aim: to improve the effectiveness of complex therapy of patients with extensive soft tissue phlegmon by relieving thrombohemorrhagic syndrome.Materials and methods. Cryoplasma-anti-enzyme therapy in the composition of complex treatment was received by 59 (48.8 %) patients of the main group, 62 (51.2 %) patients of the comparison group received only the generally accepted treatment. In each group, there are three variants of the course of the disease – moderate, severe and septic.Results. The analysis of the clinical course of the disease showed that in patients of the first group, wounds were cleared of necrotic masses and purulent discharge with filling them with healthy granulation tissue 5.3 days faster than in the second group (p˂0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The proportion of thrombotic and thromboembolic causes of death in the first group (14.3 %) was lower than in the second (17.7 %) (p˂ 0.05).Conclusion. The use of cryoplasma-anti-enzyme therapy as part of complex treatment contributed to the effective relief of thrombohemorrhagic syndrome, the elimination of microcirculatory disorders, which allowed performing plastic closure of a wound defect 1.6 times faster, prevented the progression of multiple organ failure, and contributed to a reduction in mortality. |
| first_indexed | 2024-03-08T12:16:17Z |
| format | Article |
| id | doaj.art-c15644f5d56a475abba36e7a693ec56d |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2024-04-24T17:16:22Z |
| publishDate | 2021-11-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-c15644f5d56a475abba36e7a693ec56d2024-03-28T07:49:25ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962021-11-016521222110.29413/ABS.2021-6.5.202226The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmonE. A. Tseimakh0V. Yu. Zinchenko1Altai State Medical UniversityAltai State Medical University; City Hospital No. 8Background. The treatment of purulent-inflammatory processes of soft tissues remains today an area of surgery that is not given enough attention by specialists of both inpatient and outpatient levels, with many unresolved problems. Of particular importance in the pathogenesis of purulent-septic processes are the emerging microcirculation disorders due to the formation of micro-clots. An important point that aggravates the course of the disease is the development of thrombohemorrhagic syndrome. As a result, even with a variety of antibacterial drugs and the ыavailability of new treatment methods, it is often not possible to achieve positive results in the treatment of this heavy contingent of patients.Aim: to improve the effectiveness of complex therapy of patients with extensive soft tissue phlegmon by relieving thrombohemorrhagic syndrome.Materials and methods. Cryoplasma-anti-enzyme therapy in the composition of complex treatment was received by 59 (48.8 %) patients of the main group, 62 (51.2 %) patients of the comparison group received only the generally accepted treatment. In each group, there are three variants of the course of the disease – moderate, severe and septic.Results. The analysis of the clinical course of the disease showed that in patients of the first group, wounds were cleared of necrotic masses and purulent discharge with filling them with healthy granulation tissue 5.3 days faster than in the second group (p˂0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The number of deaths decreased – 11.9 % in the first group against 27.4 % in the second group (p˂ 0.001). The proportion of thrombotic and thromboembolic causes of death in the first group (14.3 %) was lower than in the second (17.7 %) (p˂ 0.05).Conclusion. The use of cryoplasma-anti-enzyme therapy as part of complex treatment contributed to the effective relief of thrombohemorrhagic syndrome, the elimination of microcirculatory disorders, which allowed performing plastic closure of a wound defect 1.6 times faster, prevented the progression of multiple organ failure, and contributed to a reduction in mortality.https://www.actabiomedica.ru/jour/article/view/3051cryoplasma-anti-enzyme complexphlegmonthrombohemorrhagic syndromesepsismicrocirculation disorder |
| spellingShingle | E. A. Tseimakh V. Yu. Zinchenko The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon Acta Biomedica Scientifica cryoplasma-anti-enzyme complex phlegmon thrombohemorrhagic syndrome sepsis microcirculation disorder |
| title | The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon |
| title_full | The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon |
| title_fullStr | The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon |
| title_full_unstemmed | The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon |
| title_short | The importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon |
| title_sort | importance of eliminating microcirculatory disorders in the complex treatment of common soft tissue phlegmon |
| topic | cryoplasma-anti-enzyme complex phlegmon thrombohemorrhagic syndrome sepsis microcirculation disorder |
| url | https://www.actabiomedica.ru/jour/article/view/3051 |
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