Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors
Major depressive disorder (MDD) is a prevalent illness that can be precipitated by acute or chronic stress. Studies of patients with Wolfram syndrome and carriers have identified Wfs1 mutations as causative for MDD. The medial prefrontal cortex (mPFC) is known to be involved in depression and behavi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2015-09-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/08752 |
| _version_ | 1811200194243461120 |
|---|---|
| author | Prerana Shrestha Awni Mousa Nathaniel Heintz |
| author_facet | Prerana Shrestha Awni Mousa Nathaniel Heintz |
| author_sort | Prerana Shrestha |
| collection | DOAJ |
| description | Major depressive disorder (MDD) is a prevalent illness that can be precipitated by acute or chronic stress. Studies of patients with Wolfram syndrome and carriers have identified Wfs1 mutations as causative for MDD. The medial prefrontal cortex (mPFC) is known to be involved in depression and behavioral resilience, although the cell types and circuits in the mPFC that moderate depressive behaviors in response to stress have not been determined. Here, we report that deletion of Wfs1 from layer 2/3 pyramidal cells impairs the ability of the mPFC to suppress stress-induced depressive behaviors, and results in hyperactivation of the hypothalamic–pituitary–adrenal axis and altered accumulation of important growth and neurotrophic factors. Our data identify superficial layer 2/3 pyramidal cells as critical for moderation of stress in the context of depressive behaviors and suggest that dysfunction in these cells may contribute to the clinical relationship between stress and depression. |
| first_indexed | 2024-04-12T02:00:39Z |
| format | Article |
| id | doaj.art-c1569d87750842cbbcbb459112467e1e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:00:39Z |
| publishDate | 2015-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-c1569d87750842cbbcbb459112467e1e2022-12-22T03:52:41ZengeLife Sciences Publications LtdeLife2050-084X2015-09-01410.7554/eLife.08752Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviorsPrerana Shrestha0Awni Mousa1Nathaniel Heintz2Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, United StatesLaboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, United StatesLaboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, United StatesMajor depressive disorder (MDD) is a prevalent illness that can be precipitated by acute or chronic stress. Studies of patients with Wolfram syndrome and carriers have identified Wfs1 mutations as causative for MDD. The medial prefrontal cortex (mPFC) is known to be involved in depression and behavioral resilience, although the cell types and circuits in the mPFC that moderate depressive behaviors in response to stress have not been determined. Here, we report that deletion of Wfs1 from layer 2/3 pyramidal cells impairs the ability of the mPFC to suppress stress-induced depressive behaviors, and results in hyperactivation of the hypothalamic–pituitary–adrenal axis and altered accumulation of important growth and neurotrophic factors. Our data identify superficial layer 2/3 pyramidal cells as critical for moderation of stress in the context of depressive behaviors and suggest that dysfunction in these cells may contribute to the clinical relationship between stress and depression.https://elifesciences.org/articles/08752depressionstressanxietymedial prefrontal cortexwolfram syndromelayer 2/3 |
| spellingShingle | Prerana Shrestha Awni Mousa Nathaniel Heintz Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors eLife depression stress anxiety medial prefrontal cortex wolfram syndrome layer 2/3 |
| title | Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors |
| title_full | Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors |
| title_fullStr | Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors |
| title_full_unstemmed | Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors |
| title_short | Layer 2/3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors |
| title_sort | layer 2 3 pyramidal cells in the medial prefrontal cortex moderate stress induced depressive behaviors |
| topic | depression stress anxiety medial prefrontal cortex wolfram syndrome layer 2/3 |
| url | https://elifesciences.org/articles/08752 |
| work_keys_str_mv | AT preranashrestha layer23pyramidalcellsinthemedialprefrontalcortexmoderatestressinduceddepressivebehaviors AT awnimousa layer23pyramidalcellsinthemedialprefrontalcortexmoderatestressinduceddepressivebehaviors AT nathanielheintz layer23pyramidalcellsinthemedialprefrontalcortexmoderatestressinduceddepressivebehaviors |