Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells

Synthesis of Tetrahydrohonokiol Derivates and Their Evaluation for Cytotoxic Activity against CCRF-CEM Leukemia, U251 Glioblastoma and HCT-116 Colon Cancer Cells

Biphenyl neolignans such as honokiol and magnolol, which are the major active constituents of the Asian medicinal plant Magnolia officinalis, are known to exert a multitude of pharmacological and biological activities. Among these, cytotoxic and tumor growth inhibitory activity against various tumou...

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Bibliographic Details
Main Authors: Marketa Bernaskova, Nadine Kretschmer, Wolfgang Schuehly, Antje Huefner, Robert Weis, Rudolf Bauer
Format: Article
Language:English
Published: MDPI AG 2014-01-01
Series:Molecules
Subjects:
tetrahydrohonokiol derivatives
cytotoxicity
CCRF-CEM leukemia cells
U251 glioblastoma
HCT-116 colon cancer cells
Magnolia officinalis
Online Access:http://www.mdpi.com/1420-3049/19/1/1223

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