The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia
RNA molecules are a source of phenotypic diversity and an operating system that connects multiple genetic and metabolic processes in the cell. A dysregulated RNA network is a common feature of cancer. Aberrant expression of long non-coding RNA (lncRNA), micro RNA (miRNA), and circular RNA (circRNA)...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-12-01
|
| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/12/3854 |
| _version_ | 1797544094190272512 |
|---|---|
| author | Irina A. Elcheva Vladimir S. Spiegelman |
| author_facet | Irina A. Elcheva Vladimir S. Spiegelman |
| author_sort | Irina A. Elcheva |
| collection | DOAJ |
| description | RNA molecules are a source of phenotypic diversity and an operating system that connects multiple genetic and metabolic processes in the cell. A dysregulated RNA network is a common feature of cancer. Aberrant expression of long non-coding RNA (lncRNA), micro RNA (miRNA), and circular RNA (circRNA) in tumors compared to their normal counterparts, as well as the recurrent mutations in functional regulatory <i>cis</i>-acting RNA motifs have emerged as biomarkers of disease development and progression, opening avenues for the design of novel therapeutic approaches. This review looks at the progress, challenges and future prospects of targeting <i>cis</i>-acting and <i>trans</i>-acting RNA elements for leukemia diagnosis and treatment. |
| first_indexed | 2024-03-10T13:54:35Z |
| format | Article |
| id | doaj.art-c157efe3c74d4fb09271642ca6f44d68 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T13:54:35Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-c157efe3c74d4fb09271642ca6f44d682023-11-21T01:46:59ZengMDPI AGCancers2072-66942020-12-011212385410.3390/cancers12123854The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in LeukemiaIrina A. Elcheva0Vladimir S. Spiegelman1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, P.O. Box 850, MC H085, 500 University Drive, Hershey, PA 17033-0850, USADivision of Pediatric Hematology and Oncology, Department of Pediatrics, Pennsylvania State University College of Medicine, P.O. Box 850, MC H085, 500 University Drive, Hershey, PA 17033-0850, USARNA molecules are a source of phenotypic diversity and an operating system that connects multiple genetic and metabolic processes in the cell. A dysregulated RNA network is a common feature of cancer. Aberrant expression of long non-coding RNA (lncRNA), micro RNA (miRNA), and circular RNA (circRNA) in tumors compared to their normal counterparts, as well as the recurrent mutations in functional regulatory <i>cis</i>-acting RNA motifs have emerged as biomarkers of disease development and progression, opening avenues for the design of novel therapeutic approaches. This review looks at the progress, challenges and future prospects of targeting <i>cis</i>-acting and <i>trans</i>-acting RNA elements for leukemia diagnosis and treatment.https://www.mdpi.com/2072-6694/12/12/3854RNAleukemiapediatric leukemia |
| spellingShingle | Irina A. Elcheva Vladimir S. Spiegelman The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia Cancers RNA leukemia pediatric leukemia |
| title | The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia |
| title_full | The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia |
| title_fullStr | The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia |
| title_full_unstemmed | The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia |
| title_short | The Role of <i>cis</i>- and <i>trans</i>-Acting RNA Regulatory Elements in Leukemia |
| title_sort | role of i cis i and i trans i acting rna regulatory elements in leukemia |
| topic | RNA leukemia pediatric leukemia |
| url | https://www.mdpi.com/2072-6694/12/12/3854 |
| work_keys_str_mv | AT irinaaelcheva theroleoficisianditransiactingrnaregulatoryelementsinleukemia AT vladimirsspiegelman theroleoficisianditransiactingrnaregulatoryelementsinleukemia AT irinaaelcheva roleoficisianditransiactingrnaregulatoryelementsinleukemia AT vladimirsspiegelman roleoficisianditransiactingrnaregulatoryelementsinleukemia |