Selective Depletion of ZAP-Binding CpG Motifs in HCV Evolution

Selective Depletion of ZAP-Binding CpG Motifs in HCV Evolution

Hepatitis C virus (HCV) is a bloodborne pathogen that can cause chronic liver disease and hepatocellular carcinoma. The loss of CpGs from virus genomes allows escape from restriction by the host zinc-finger antiviral protein (ZAP). The evolution of HCV in the human host has not been explored in the...

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Bibliographic Details
Main Authors: Sanket Mukherjee, Akhil Kumar, Jasmine Samal, Ekta Gupta, Perumal Vivekanandan, Manoj B. Menon
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Pathogens
Subjects:
HCV
CpG depletion
ZAP-binding motif
pathogenesis
evolution
HCV core gene
Online Access:https://www.mdpi.com/2076-0817/12/1/43

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