Oxidative Stress Biomarkers among Schizophrenia Inpatients
Background. Finding the associations between schizophrenia symptoms and the biomarkers of inflammation, oxidative stress and the kynurenine pathway may lead to the individualization of treatment and increase its effectiveness. Methods. The study group included 82 schizophrenia inpatients. The Positi...
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MDPI AG
2023-03-01
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| author | Magdalena Więdłocha Natalia Zborowska Piotr Marcinowicz Weronika Dębowska Marta Dębowska Anna Zalewska Mateusz Maciejczyk Napoleon Waszkiewicz Agata Szulc |
| author_facet | Magdalena Więdłocha Natalia Zborowska Piotr Marcinowicz Weronika Dębowska Marta Dębowska Anna Zalewska Mateusz Maciejczyk Napoleon Waszkiewicz Agata Szulc |
| author_sort | Magdalena Więdłocha |
| collection | DOAJ |
| description | Background. Finding the associations between schizophrenia symptoms and the biomarkers of inflammation, oxidative stress and the kynurenine pathway may lead to the individualization of treatment and increase its effectiveness. Methods. The study group included 82 schizophrenia inpatients. The Positive and Negative Symptoms Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS) and the Calgary Depression in Schizophrenia Scale were used for symptom evaluation. Biochemical analyses included oxidative stress parameters and brain-derived neurotrophic factor (BDNF). Results. Linear models revealed the following: (1) malondiadehyde (MDA), N-formylkynurenine (N-formKYN), advanced oxidation protein products (AOPP), advanced glycation end-products of proteins (AGE) and total oxidative status (TOS) levels are related to the PANSS-total score; (2) MDA, reduced glutathione (GSH) and BDNF levels are related to the PANSS-negative score; (3) TOS and kynurenine (KYN) levels are related to the PANSS-positive score; (4) levels of total antioxidant status (TAS) and AOPP along with the CDSS score are related to the BACS-total score; (5) TAS and N-formKYN levels are related to the BACS-working memory score. Conclusions. Oxidative stress biomarkers may be associated with the severity of schizophrenia symptoms in positive, negative and cognitive dimensions. The identification of biochemical markers associated with the specific symptom clusters may increase the understanding of biochemical profiles in schizophrenia patients. |
| first_indexed | 2024-03-11T06:50:57Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-11T06:50:57Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-c1596c182a6c4e86aa0c994b9cc990a92023-11-17T10:00:34ZengMDPI AGBrain Sciences2076-34252023-03-0113349010.3390/brainsci13030490Oxidative Stress Biomarkers among Schizophrenia InpatientsMagdalena Więdłocha0Natalia Zborowska1Piotr Marcinowicz2Weronika Dębowska3Marta Dębowska4Anna Zalewska5Mateusz Maciejczyk6Napoleon Waszkiewicz7Agata Szulc8Department of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, PolandExperimental Dentistry Laboratory, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok, 15-089 Bialystok, PolandDepartment of Psychiatry, Medical University of Bialystok, 16-070 Choroszcz, PolandDepartment of Psychiatry, Faculty of Health Sciences, Medical University of Warsaw, 02-091 Warsaw, PolandBackground. Finding the associations between schizophrenia symptoms and the biomarkers of inflammation, oxidative stress and the kynurenine pathway may lead to the individualization of treatment and increase its effectiveness. Methods. The study group included 82 schizophrenia inpatients. The Positive and Negative Symptoms Scale (PANSS), the Brief Assessment of Cognition in Schizophrenia (BACS) and the Calgary Depression in Schizophrenia Scale were used for symptom evaluation. Biochemical analyses included oxidative stress parameters and brain-derived neurotrophic factor (BDNF). Results. Linear models revealed the following: (1) malondiadehyde (MDA), N-formylkynurenine (N-formKYN), advanced oxidation protein products (AOPP), advanced glycation end-products of proteins (AGE) and total oxidative status (TOS) levels are related to the PANSS-total score; (2) MDA, reduced glutathione (GSH) and BDNF levels are related to the PANSS-negative score; (3) TOS and kynurenine (KYN) levels are related to the PANSS-positive score; (4) levels of total antioxidant status (TAS) and AOPP along with the CDSS score are related to the BACS-total score; (5) TAS and N-formKYN levels are related to the BACS-working memory score. Conclusions. Oxidative stress biomarkers may be associated with the severity of schizophrenia symptoms in positive, negative and cognitive dimensions. The identification of biochemical markers associated with the specific symptom clusters may increase the understanding of biochemical profiles in schizophrenia patients.https://www.mdpi.com/2076-3425/13/3/490oxidative stresskynurenine pathwayschizophrenia |
| spellingShingle | Magdalena Więdłocha Natalia Zborowska Piotr Marcinowicz Weronika Dębowska Marta Dębowska Anna Zalewska Mateusz Maciejczyk Napoleon Waszkiewicz Agata Szulc Oxidative Stress Biomarkers among Schizophrenia Inpatients Brain Sciences oxidative stress kynurenine pathway schizophrenia |
| title | Oxidative Stress Biomarkers among Schizophrenia Inpatients |
| title_full | Oxidative Stress Biomarkers among Schizophrenia Inpatients |
| title_fullStr | Oxidative Stress Biomarkers among Schizophrenia Inpatients |
| title_full_unstemmed | Oxidative Stress Biomarkers among Schizophrenia Inpatients |
| title_short | Oxidative Stress Biomarkers among Schizophrenia Inpatients |
| title_sort | oxidative stress biomarkers among schizophrenia inpatients |
| topic | oxidative stress kynurenine pathway schizophrenia |
| url | https://www.mdpi.com/2076-3425/13/3/490 |
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