Trends in hepatocellular carcinoma in Louisiana, 2005–2015
Introduction: Louisiana has one of the highest incidence and mortality rates of hepatocellular carcinoma (HCC) in the nation. The aim of this study was to analyze the trends in HCC incidence and relative survival rates in Louisiana and compare them with corresponding national rates, which can be use...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Dialogues in Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772653322000417 |
| _version_ | 1811178661621006336 |
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| author | John M. Lyons, III Denise M. Danos Lauren Maniscalco Yong Yi Xiao-Cheng Wu Quyen D. Chu |
| author_facet | John M. Lyons, III Denise M. Danos Lauren Maniscalco Yong Yi Xiao-Cheng Wu Quyen D. Chu |
| author_sort | John M. Lyons, III |
| collection | DOAJ |
| description | Introduction: Louisiana has one of the highest incidence and mortality rates of hepatocellular carcinoma (HCC) in the nation. The aim of this study was to analyze the trends in HCC incidence and relative survival rates in Louisiana and compare them with corresponding national rates, which can be used to formulate strategies to improve Louisiana HCC outcomes. Methods: Data on primary invasive HCC diagnosed in patients 20 years or older between 2005 and 2015 were obtained from the Surveillance, Epidemiology and End Results (SEER) program and Louisiana Tumor Registry. Time trends in HCC incidence and 12-month relative survival were analyzed using Joinpoint regression. Case characteristics were compared on 2 time periods (2005–2009 and 2010–2015) using Chi-squared tests. Cause-specific survival was analyzed via log-rank and multivariable Cox proportional hazard model. Results: Over the study period, the average annual percent change (AAPC) in age-adjusted HCC incidence in Louisiana was nearly double that of the national estimate, 6% (95% CI: 4.7, 7.3) compared to 3.1% (95% CI: 2.4, 3.7). 12-month relative survival among HCC patients in Louisiana was 40.7% (95% CI: 38.9, 42.4) which was significantly less than the US rate of 48.2% (95% CI: 47.8, 48.6). Relative survival did improve in Louisiana from 2000 to 2015 at a rate similar to that of the US (AAPC (95% CI): 2.9 (0.7, 5.2) vs. 2.7 (2.3, 3.1), p = 0.8). In multivariable survival analysis, factors amongst Louisianans associated with worse survival were older age at diagnosis, advanced stage of disease, and lack of surgical therapy. Conclusion: The incidence of HCC continues to rise more dramatically in Louisiana than in the US. While some modest improvements in HCC survival have been realized, outcomes remain dismal. Future work identifying the most at-risk populations are needed to inform statewide public health initiatives. |
| first_indexed | 2024-04-11T06:23:20Z |
| format | Article |
| id | doaj.art-c15b801018e0498e99ba42d50cd4a347 |
| institution | Directory Open Access Journal |
| issn | 2772-6533 |
| language | English |
| last_indexed | 2024-04-11T06:23:20Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Dialogues in Health |
| spelling | doaj.art-c15b801018e0498e99ba42d50cd4a3472022-12-22T04:40:30ZengElsevierDialogues in Health2772-65332022-12-011100041Trends in hepatocellular carcinoma in Louisiana, 2005–2015John M. Lyons, III0Denise M. Danos1Lauren Maniscalco2Yong Yi3Xiao-Cheng Wu4Quyen D. Chu5Our Lady of the Lake Regional Medical Center at Baton Rouge, Baton Rouge, Louisiana, United States of America; School of Medicine, Louisiana State University Health Sciences Center-New Orleans, New Orleans, Louisiana, United States of America; Corresponding author at: Louisiana State University Health Sciences Center-New Orleans, Our Lady of the Lake-Mary Bird Perkins Cancer Center, 7777 Hennessy Blvd, Baton Rouge, LA 70808, United States of America.School of Public Health, Louisiana State University Health Sciences Center-New Orleans, New Orleans, Louisiana, United States of AmericaLouisiana Tumor Registry, Louisiana State University Health Sciences Center-New Orleans, Louisiana, United States of AmericaLouisiana Tumor Registry, Louisiana State University Health Sciences Center-New Orleans, Louisiana, United States of AmericaSchool of Public Health, Louisiana State University Health Sciences Center-New Orleans, New Orleans, Louisiana, United States of America; Louisiana Tumor Registry, Louisiana State University Health Sciences Center-New Orleans, Louisiana, United States of AmericaDepartment of Surgery, Louisiana State University Health Sciences Center-Shreveport, Louisiana, United States of AmericaIntroduction: Louisiana has one of the highest incidence and mortality rates of hepatocellular carcinoma (HCC) in the nation. The aim of this study was to analyze the trends in HCC incidence and relative survival rates in Louisiana and compare them with corresponding national rates, which can be used to formulate strategies to improve Louisiana HCC outcomes. Methods: Data on primary invasive HCC diagnosed in patients 20 years or older between 2005 and 2015 were obtained from the Surveillance, Epidemiology and End Results (SEER) program and Louisiana Tumor Registry. Time trends in HCC incidence and 12-month relative survival were analyzed using Joinpoint regression. Case characteristics were compared on 2 time periods (2005–2009 and 2010–2015) using Chi-squared tests. Cause-specific survival was analyzed via log-rank and multivariable Cox proportional hazard model. Results: Over the study period, the average annual percent change (AAPC) in age-adjusted HCC incidence in Louisiana was nearly double that of the national estimate, 6% (95% CI: 4.7, 7.3) compared to 3.1% (95% CI: 2.4, 3.7). 12-month relative survival among HCC patients in Louisiana was 40.7% (95% CI: 38.9, 42.4) which was significantly less than the US rate of 48.2% (95% CI: 47.8, 48.6). Relative survival did improve in Louisiana from 2000 to 2015 at a rate similar to that of the US (AAPC (95% CI): 2.9 (0.7, 5.2) vs. 2.7 (2.3, 3.1), p = 0.8). In multivariable survival analysis, factors amongst Louisianans associated with worse survival were older age at diagnosis, advanced stage of disease, and lack of surgical therapy. Conclusion: The incidence of HCC continues to rise more dramatically in Louisiana than in the US. While some modest improvements in HCC survival have been realized, outcomes remain dismal. Future work identifying the most at-risk populations are needed to inform statewide public health initiatives.http://www.sciencedirect.com/science/article/pii/S2772653322000417Hepatocellular carcinomaLouisianaIncidenceMortalityTrends |
| spellingShingle | John M. Lyons, III Denise M. Danos Lauren Maniscalco Yong Yi Xiao-Cheng Wu Quyen D. Chu Trends in hepatocellular carcinoma in Louisiana, 2005–2015 Dialogues in Health Hepatocellular carcinoma Louisiana Incidence Mortality Trends |
| title | Trends in hepatocellular carcinoma in Louisiana, 2005–2015 |
| title_full | Trends in hepatocellular carcinoma in Louisiana, 2005–2015 |
| title_fullStr | Trends in hepatocellular carcinoma in Louisiana, 2005–2015 |
| title_full_unstemmed | Trends in hepatocellular carcinoma in Louisiana, 2005–2015 |
| title_short | Trends in hepatocellular carcinoma in Louisiana, 2005–2015 |
| title_sort | trends in hepatocellular carcinoma in louisiana 2005 2015 |
| topic | Hepatocellular carcinoma Louisiana Incidence Mortality Trends |
| url | http://www.sciencedirect.com/science/article/pii/S2772653322000417 |
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