Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants
Preterm infants are particularly vulnerable to developing iodine deficiency. Donor human milk (DHM) is the preferred feeding option if the mother’s own milk (MOM) is not available, but information on DHM iodine concentration (DHMIC) is lacking. Hence, we aimed to assess DHMIC to further evaluate the...
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| author | Noelia Ureta-Velasco Kristin Keller Diana Escuder-Vieco José C. E. Serrano Nadia Raquel García-Lara Carmen R. Pallás-Alonso |
| author_facet | Noelia Ureta-Velasco Kristin Keller Diana Escuder-Vieco José C. E. Serrano Nadia Raquel García-Lara Carmen R. Pallás-Alonso |
| author_sort | Noelia Ureta-Velasco |
| collection | DOAJ |
| description | Preterm infants are particularly vulnerable to developing iodine deficiency. Donor human milk (DHM) is the preferred feeding option if the mother’s own milk (MOM) is not available, but information on DHM iodine concentration (DHMIC) is lacking. Hence, we aimed to assess DHMIC to further evaluate the adequacy of iodine provision in preterm infants. Finally, associations that might influence DHMIC were studied. In 113 donors, we measured iodine intake by evaluating dietary records for five consecutive days with the DIAL<sup>®</sup> Software. From the second day of dietary record, donors provided human milk samples (at least one per day) for four consecutive days. Daily human milk samples were analyzed for DHMIC. A DHMIC ≥ 200 µg/L was considered an adequate iodine content for preterm infants. DHMIC and urine iodine concentration (UIC) were determined using ICP-MS. In our study, 83.2% of donors had a full-term infant. Breastfeeding time range was 1.5–49.4 months. During the dietary record, 55.8% took iodine-containing supplements, providing 40–200 µg/day of iodine. The medians (p25, p75) UIC and DHMIC were 112.4 (75.8, 160.1) and 148.5 (97.6, 206.1) µg/L, respectively. In this iodine-sufficient population, 70% had a DHMIC of <200 µg/L. Donors’ intake of iodine-containing supplements was associated with higher DHMIC. |
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| format | Article |
| id | doaj.art-c15b8b37db8d4a4e9463a87325e02184 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T19:39:45Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-c15b8b37db8d4a4e9463a87325e021842023-11-24T01:44:12ZengMDPI AGNutrients2072-66432022-10-011420430410.3390/nu14204304Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm InfantsNoelia Ureta-Velasco0Kristin Keller1Diana Escuder-Vieco2José C. E. Serrano3Nadia Raquel García-Lara4Carmen R. Pallás-Alonso5Department of Neonatology, 12 de Octubre University Hospital, Research Institute i+12, Complutense University of Madrid, 28041 Madrid, Spain“Aladina-MGU”—Regional Human Milk Bank, 12 de Octubre University Hospital, Research Institute i+12, 28041 Madrid, Spain“Aladina-MGU”—Regional Human Milk Bank, 12 de Octubre University Hospital, Research Institute i+12, 28041 Madrid, SpainDepartment of Experimental Medicine, Medicine Faculty, Lleida University, 25008 Lleida, SpainDepartment of Neonatology, 12 de Octubre University Hospital, Research Institute i+12, Complutense University of Madrid, 28041 Madrid, SpainDepartment of Neonatology, 12 de Octubre University Hospital, Research Institute i+12, Complutense University of Madrid, 28041 Madrid, SpainPreterm infants are particularly vulnerable to developing iodine deficiency. Donor human milk (DHM) is the preferred feeding option if the mother’s own milk (MOM) is not available, but information on DHM iodine concentration (DHMIC) is lacking. Hence, we aimed to assess DHMIC to further evaluate the adequacy of iodine provision in preterm infants. Finally, associations that might influence DHMIC were studied. In 113 donors, we measured iodine intake by evaluating dietary records for five consecutive days with the DIAL<sup>®</sup> Software. From the second day of dietary record, donors provided human milk samples (at least one per day) for four consecutive days. Daily human milk samples were analyzed for DHMIC. A DHMIC ≥ 200 µg/L was considered an adequate iodine content for preterm infants. DHMIC and urine iodine concentration (UIC) were determined using ICP-MS. In our study, 83.2% of donors had a full-term infant. Breastfeeding time range was 1.5–49.4 months. During the dietary record, 55.8% took iodine-containing supplements, providing 40–200 µg/day of iodine. The medians (p25, p75) UIC and DHMIC were 112.4 (75.8, 160.1) and 148.5 (97.6, 206.1) µg/L, respectively. In this iodine-sufficient population, 70% had a DHMIC of <200 µg/L. Donors’ intake of iodine-containing supplements was associated with higher DHMIC.https://www.mdpi.com/2072-6643/14/20/4304breast milkdonor human milkhuman milk bankiodine intakeiodine in lactating womenurine iodine concentration |
| spellingShingle | Noelia Ureta-Velasco Kristin Keller Diana Escuder-Vieco José C. E. Serrano Nadia Raquel García-Lara Carmen R. Pallás-Alonso Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants Nutrients breast milk donor human milk human milk bank iodine intake iodine in lactating women urine iodine concentration |
| title | Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants |
| title_full | Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants |
| title_fullStr | Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants |
| title_full_unstemmed | Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants |
| title_short | Assessment of Iodine Concentration in Human Milk from Donors: Implications for Preterm Infants |
| title_sort | assessment of iodine concentration in human milk from donors implications for preterm infants |
| topic | breast milk donor human milk human milk bank iodine intake iodine in lactating women urine iodine concentration |
| url | https://www.mdpi.com/2072-6643/14/20/4304 |
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