New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels

New Flurbiprofen Derivatives: Synthesis, Membrane Affinity and Evaluation of in Vitro Effect on β-Amyloid Levels

Alzheimer’s disease (AD) is characterized by irreversible and progressive loss of memory and cognition and profound neuronal loss. Current therapeutic strategies for the treatment of AD have been directed to a variety of targets with the aim of reversing or preventing the disease but, unfortunately,...

Full description

Bibliographic Details
Main Authors:	Stephanie Pacella, Lucia Grumetto, Francesco Barbato, Dario Ambrosini, Gianfabio Giorgioni, Hasan Türkez, Antonella Fontana, Ivana Cacciatore, Lisa Marinelli, Piera Sozio, Amelia Cataldi, Antonio Di Stefano
Format:	Article
Language:	English
Published:	MDPI AG 2013-09-01
Series:	Molecules
Subjects:	Alzheimer’s disease beta amyloid peptide flurbiprofen γ-secretase
Online Access:	http://www.mdpi.com/1420-3049/18/9/10747

Similar Items

Modulation of γ-Secretase Activity by a Carborane-Based Flurbiprofen Analogue
by: Stefan Saretz, et al.
Published: (2021-05-01)

The Comparison of Plasma and Cerebrospinal Fluid R(−)- and S(+)-Flurbiprofen Concentration After Intravenous Injection of Flurbiprofen Axetil in Human Subjects
by: Han Yao, et al.
Published: (2021-04-01)

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
by: Frank Raven, et al.
Published: (2017-10-01)

Modulation of γ-secretase by EVP-0015962 reduces amyloid deposition and behavioral deficits in Tg2576 mice
by: Rogers Kathryn, et al.
Published: (2012-12-01)

Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28
by: Li-Mei Chen, et al.
Published: (2019-01-01)

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease
by: Jing Zhao, et al.
Published: (2020-08-01)

Residues at P2-P1 positions of ɛ- and ζ-cleavage sites are important in formation of β-amyloid peptide
by: Jianxin Tan, et al.
Published: (2009-12-01)

Flurbiprofen loaded ethosomes - transdermal delivery of anti-inflammatory effect in rat model
by: Sarvesh Paliwal, et al.
Published: (2019-06-01)

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production
by: Loukia Parisiadou, et al.
Published: (2008-06-01)

Population pharmacokinetic modeling of flurbiprofen, the active metabolite of flurbiprofen axetil, in Chinese patients with postoperative pain
by: Zhang J, et al.
Published: (2018-11-01)

Comparison of the analgesic efficacy of spray and tablet flurbiprofen for pain after soft tissue surgery
by: Cennet Neslihan Eroglu, et al.
Published: (2024-11-01)

Stability-indicating RP-HPLC method for simultaneous determination of gatifloxacin and flurbiprofen in binary combination
by: Islam Ullah Khan, et al.
Published: (2014-04-01)

Oxidative stress and lipid peroxidation are upstream of amyloid pathology
by: Muriel Arimon, et al.
Published: (2015-12-01)

Population Pharmacokinetic Modeling of Flurbiprofen, the Active Metabolite of Flurbiprofen Axetil, in Chinese Patients with Postoperative Pain [Corrigendum]
by: Zhang J, et al.
Published: (2020-03-01)

Liraglutide improves cognition function in streptozotocin-induced diabetic rats by downregulating β-secretase and γ-secretase and alleviating oxidative stress in HT-22 cells
by: Lou-yan Ma, et al.
Published: (2025-03-01)

Effect of flurbiprofen sodium on pupillary dilatation during scleral buckling surgery
by: Roysarkar T, et al.
Published: (1994-01-01)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
by: Maho eMorishima-Kawashima
Published: (2014-11-01)

Use of Flurbiprofen Ester in 4-Dimensional Hysterosalpingography: Does Flurbiprofen Ester Relieve Pain During an Infertility Evaluation?
by: Long Tan, et al.
Published: (2024-07-01)

Cyclodextrine Based Nanogels and Phase Solubility Studies of Flurbiprofen as a Chemopreventive Agent
by: Ayşe Nur Oktay, et al.
Published: (2017-11-01)

Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterol
by: Vladimir Rudajev, et al.
Published: (2023-09-01)

Solubility and dissolution enhancement of flurbiprofen by solid dispersion using hydrophilic carriers
by: Bhaskar Daravath, et al.
Published: (2018-05-01)

Ethylenediamine Salt Enhances the Solubility and Dissolution of Flurbiprofen
by: Dr. Lei Gao, et al.
Published: (2024-06-01)

Enantioselective esterification of (R,S)-flurbiprofen catalyzed by lipase in ionic liquid
by: Ruihong Zhao, et al.
Published: (2017-01-01)

Investigation of the parameters affecting the release of flurbiprofen from chitosan microspheres
by: Müşerref Günseli Yüksel Tilkan, et al.
Published: (2018-04-01)

The β amyloid peptide can act as a modular aggregation domain
by: Christopher D. Link, et al.
Published: (2008-12-01)

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines
by: Alessio Colombo, et al.
Published: (2013-01-01)

Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors
by: Svetlana Sharifulina, et al.
Published: (2022-10-01)

The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase
by: Yuan Li, et al.
Published: (2024-02-01)

BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer’s Disease
by: Miguel A. Maia, et al.
Published: (2019-03-01)

A simple high-performance liquid chromatographic practical approach for determination of flurbiprofen
by: Muhammad Akhlaq, et al.
Published: (2011-01-01)

Preparation and evaluation of oral soft chewable jelly containing flurbiprofen
by: Lubna Abdalkarim Sabri, et al.
Published: (2022-01-01)

Physicochemical Properties and Transdermal Absorption of a Flurbiprofen and Lidocaine Complex in the Non-Crystalline Form
by: Qihui Xu, et al.
Published: (2023-01-01)

A Systematic Review of Flurbiprofen 8.75 mg Dose and Risk of Haemorrhagic Events
by: Sandeep Dhanda, et al.
Published: (2021-08-01)

Effect of flurbiprofen axetil on postoperative delirium for elderly patients
by: Xifan Wang, et al.
Published: (2019-06-01)

Preparation and Study on the Single-Crystal Structure of Flurbiprofen–Salicylamide Co-crystal
by: Jia-Wei Hou, et al.
Published: (2023-06-01)

Association between perioperative flurbiprofen administration and acute kidney injury (AKI) in spine surgery: a retrospective cohort study
by: Yongrong Liu, et al.
Published: (2024-06-01)

Mutations in APP have independent effects on Aβ and CTFγ generation
by: Silva Hecimovic, et al.
Published: (2004-11-01)

Hydroxypropylcellulose-flurbiprofen conjugates: design, characterization, anti-inflammatory activity and enhanced bioavailability
by: Muhammad Ajaz Hussain, et al.
Published: (2020-07-01)

Case Report: Flurbiprofen-induced Type I Kounis syndrome
by: Chao Tang, et al.
Published: (2023-11-01)

Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis
by: Lukas P Feilen, et al.
Published: (2022-05-01)