Microbiota metabolites in bone: Shaping health and Confronting disease
The intricate interplay between the gut microbiota and bone health has become increasingly recognized as a fundamental determinant of skeletal well-being. Microbiota-derived metabolites play a crucial role in dynamic interaction, specifically in bone homeostasis. In this sense, short-chain fatty aci...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-04-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024044669 |
| _version_ | 1797245006260469760 |
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| author | Dong Han Weijiao Wang Jinpeng Gong Yupeng Ma Yu Li |
| author_facet | Dong Han Weijiao Wang Jinpeng Gong Yupeng Ma Yu Li |
| author_sort | Dong Han |
| collection | DOAJ |
| description | The intricate interplay between the gut microbiota and bone health has become increasingly recognized as a fundamental determinant of skeletal well-being. Microbiota-derived metabolites play a crucial role in dynamic interaction, specifically in bone homeostasis. In this sense, short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, indirectly promote bone formation by regulating insulin-like growth factor-1 (IGF-1). Trimethylamine N-oxide (TMAO) has been found to increase the expression of osteoblast genes, such as Runt-related transcription factor 2 (RUNX2) and bone morphogenetic protein-2 (BMP2), thus enhancing osteogenic differentiation and bone quality through BMP/SMADs and Wnt signaling pathways. Remarkably, in the context of bone infections, the role of microbiota metabolites in immune modulation and host defense mechanisms potentially affects susceptibility to infections such as osteomyelitis. Furthermore, ongoing research elucidates the precise mechanisms through which microbiota-derived metabolites influence bone cells, such as osteoblasts and osteoclasts. Understanding the multifaceted influence of microbiota metabolites on bone, from regulating homeostasis to modulating susceptibility to infections, has the potential to revolutionize our approach to bone health and disease management. This review offers a comprehensive exploration of this evolving field, providing a holistic perspective on the impact of microbiota metabolites on bone health and diseases. |
| first_indexed | 2024-04-24T19:20:02Z |
| format | Article |
| id | doaj.art-c1605b14de7b44cdbe6e68d64577f636 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T19:20:02Z |
| publishDate | 2024-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c1605b14de7b44cdbe6e68d64577f6362024-03-26T04:26:52ZengElsevierHeliyon2405-84402024-04-01107e28435Microbiota metabolites in bone: Shaping health and Confronting diseaseDong Han0Weijiao Wang1Jinpeng Gong2Yupeng Ma3Yu Li4Department of Trauma Orthopedics, Yantaishan Hospital, Yantai 264000, ChinaDepartment of Otolaryngology, Yantaishan Hospital, Yantai 264000, ChinaDepartment of Trauma Orthopedics, Yantaishan Hospital, Yantai 264000, ChinaDepartment of Trauma Orthopedics, Yantaishan Hospital, Yantai 264000, ChinaDepartment of Trauma Orthopedics, Yantaishan Hospital, Yantai 264000, China; Corresponding author.The intricate interplay between the gut microbiota and bone health has become increasingly recognized as a fundamental determinant of skeletal well-being. Microbiota-derived metabolites play a crucial role in dynamic interaction, specifically in bone homeostasis. In this sense, short-chain fatty acids (SCFAs), including acetate, propionate, and butyrate, indirectly promote bone formation by regulating insulin-like growth factor-1 (IGF-1). Trimethylamine N-oxide (TMAO) has been found to increase the expression of osteoblast genes, such as Runt-related transcription factor 2 (RUNX2) and bone morphogenetic protein-2 (BMP2), thus enhancing osteogenic differentiation and bone quality through BMP/SMADs and Wnt signaling pathways. Remarkably, in the context of bone infections, the role of microbiota metabolites in immune modulation and host defense mechanisms potentially affects susceptibility to infections such as osteomyelitis. Furthermore, ongoing research elucidates the precise mechanisms through which microbiota-derived metabolites influence bone cells, such as osteoblasts and osteoclasts. Understanding the multifaceted influence of microbiota metabolites on bone, from regulating homeostasis to modulating susceptibility to infections, has the potential to revolutionize our approach to bone health and disease management. This review offers a comprehensive exploration of this evolving field, providing a holistic perspective on the impact of microbiota metabolites on bone health and diseases.http://www.sciencedirect.com/science/article/pii/S2405844024044669MicrobiotaSCFAsBile acids boneTryptophane-derived metabolitesTMAOOsteoblast |
| spellingShingle | Dong Han Weijiao Wang Jinpeng Gong Yupeng Ma Yu Li Microbiota metabolites in bone: Shaping health and Confronting disease Heliyon Microbiota SCFAs Bile acids bone Tryptophane-derived metabolites TMAO Osteoblast |
| title | Microbiota metabolites in bone: Shaping health and Confronting disease |
| title_full | Microbiota metabolites in bone: Shaping health and Confronting disease |
| title_fullStr | Microbiota metabolites in bone: Shaping health and Confronting disease |
| title_full_unstemmed | Microbiota metabolites in bone: Shaping health and Confronting disease |
| title_short | Microbiota metabolites in bone: Shaping health and Confronting disease |
| title_sort | microbiota metabolites in bone shaping health and confronting disease |
| topic | Microbiota SCFAs Bile acids bone Tryptophane-derived metabolites TMAO Osteoblast |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024044669 |
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