The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia
Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological sympt...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/9/2619 |
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| author | Katarzyna Rek-Owodziń Ernest Tyburski Piotr Plichta Katarzyna Waszczuk Maksymilian Bielecki Krzysztof Wietrzyński Piotr Podwalski Krzysztof Rudkowski Anna Michalczyk Tomasz Grąźlewski Leszek Sagan Jolanta Kucharska-Mazur Jerzy Samochowiec Monika Mak |
| author_facet | Katarzyna Rek-Owodziń Ernest Tyburski Piotr Plichta Katarzyna Waszczuk Maksymilian Bielecki Krzysztof Wietrzyński Piotr Podwalski Krzysztof Rudkowski Anna Michalczyk Tomasz Grąźlewski Leszek Sagan Jolanta Kucharska-Mazur Jerzy Samochowiec Monika Mak |
| author_sort | Katarzyna Rek-Owodziń |
| collection | DOAJ |
| description | Impairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients. |
| first_indexed | 2024-03-10T04:00:47Z |
| format | Article |
| id | doaj.art-c1609c7f4f8c45c4bc6c853534054d87 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:00:47Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-c1609c7f4f8c45c4bc6c853534054d872023-11-23T08:34:56ZengMDPI AGJournal of Clinical Medicine2077-03832022-05-01119261910.3390/jcm11092619The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic SchizophreniaKatarzyna Rek-Owodziń0Ernest Tyburski1Piotr Plichta2Katarzyna Waszczuk3Maksymilian Bielecki4Krzysztof Wietrzyński5Piotr Podwalski6Krzysztof Rudkowski7Anna Michalczyk8Tomasz Grąźlewski9Leszek Sagan10Jolanta Kucharska-Mazur11Jerzy Samochowiec12Monika Mak13Department of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Neurosurgery, Pomeranian Medical University in Szczecin, 71-252 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Psychiatry, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandDepartment of Health Psychology, Pomeranian Medical University in Szczecin, 71-457 Szczecin, PolandImpairments in cognitive functions are one of the main features of schizophrenia. A variety of factors can influence the extent of cognitive deficits. In our study, we examined the severity of cognitive deficits at different stages of the disease and the relationship between psychopathological symptoms and cognitive functions. We recruited 32 patients with first-episode psychosis (FEP), 70 with chronic schizophrenia (CS), and 39 healthy controls (HC). Psychopathological symptoms were evaluated with the Positive and Negative Syndrome Scale (PANSS) and cognitive functions were measured with the MATRICS Cognitive Consensus Battery (MCCB). Cognitive deficits were present in both FEP and CS participants. CS individuals had lower overall scores and poorer working memory; however, clinical variables appeared to play a significant role in these scores. In FEP, disorganization correlated negatively with verbal and visual learning and memory, social cognition, and overall score; negative symptoms negatively correlated with social cognition. In CS participants, disorganization correlated negatively with speed of processing, reasoning, problem solving, and overall score; negative symptoms were negatively correlated with speed of processing, visual learning, memory, and overall score; positive symptoms were negatively correlated with reasoning and problem solving. Our findings indicate that psychopathological symptoms have a significant impact on cognitive functions in FEP and CS patients.https://www.mdpi.com/2077-0383/11/9/2619first-episode psychosischronic schizophreniacognitive functionspsychopathologyMATRICS Consensus Cognitive BatteryMCCB |
| spellingShingle | Katarzyna Rek-Owodziń Ernest Tyburski Piotr Plichta Katarzyna Waszczuk Maksymilian Bielecki Krzysztof Wietrzyński Piotr Podwalski Krzysztof Rudkowski Anna Michalczyk Tomasz Grąźlewski Leszek Sagan Jolanta Kucharska-Mazur Jerzy Samochowiec Monika Mak The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia Journal of Clinical Medicine first-episode psychosis chronic schizophrenia cognitive functions psychopathology MATRICS Consensus Cognitive Battery MCCB |
| title | The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia |
| title_full | The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia |
| title_fullStr | The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia |
| title_full_unstemmed | The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia |
| title_short | The Relationship between Cognitive Functions and Psychopathological Symptoms in First Episode Psychosis and Chronic Schizophrenia |
| title_sort | relationship between cognitive functions and psychopathological symptoms in first episode psychosis and chronic schizophrenia |
| topic | first-episode psychosis chronic schizophrenia cognitive functions psychopathology MATRICS Consensus Cognitive Battery MCCB |
| url | https://www.mdpi.com/2077-0383/11/9/2619 |
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