Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved]
Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2017-10-01
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| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/6-1860/v1 |
| _version_ | 1828838360599232512 |
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| author | Carmen Mirabelli Els Scheers Johan Neyts |
| author_facet | Carmen Mirabelli Els Scheers Johan Neyts |
| author_sort | Carmen Mirabelli |
| collection | DOAJ |
| description | Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD. |
| first_indexed | 2024-12-12T19:01:00Z |
| format | Article |
| id | doaj.art-c160f0842a324e87af678042e5fc82dd |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-12T19:01:00Z |
| publishDate | 2017-10-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-c160f0842a324e87af678042e5fc82dd2022-12-22T00:15:06ZengF1000 Research LtdF1000Research2046-14022017-10-01610.12688/f1000research.11978.112951Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved]Carmen Mirabelli0Els Scheers1Johan Neyts2Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, BelgiumLaboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, BelgiumLaboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Leuven, BelgiumRhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD.https://f1000research.com/articles/6-1860/v1Allergy & HypersensitivityAntimicrobials & Drug ResistanceAsthma & Allergic RhinitisCellular Microbiology & PathogenesisCOPD & Allied DisordersImmunity to InfectionsMedical MicrobiologyRespiratory InfectionsRespiratory PediatricsVirology |
| spellingShingle | Carmen Mirabelli Els Scheers Johan Neyts Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved] F1000Research Allergy & Hypersensitivity Antimicrobials & Drug Resistance Asthma & Allergic Rhinitis Cellular Microbiology & Pathogenesis COPD & Allied Disorders Immunity to Infections Medical Microbiology Respiratory Infections Respiratory Pediatrics Virology |
| title | Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved] |
| title_full | Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved] |
| title_fullStr | Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved] |
| title_full_unstemmed | Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved] |
| title_short | Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved] |
| title_sort | novel therapeutic approaches to simultaneously target rhinovirus infection and asthma copd pathogenesis version 1 referees 2 approved |
| topic | Allergy & Hypersensitivity Antimicrobials & Drug Resistance Asthma & Allergic Rhinitis Cellular Microbiology & Pathogenesis COPD & Allied Disorders Immunity to Infections Medical Microbiology Respiratory Infections Respiratory Pediatrics Virology |
| url | https://f1000research.com/articles/6-1860/v1 |
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