High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease
<p><strong>Foundation:</strong> High-sensitivity C-reactive protein and homocysteine seem to be related to ischemic cerebrovascular disease, but their findings on the risk and prognosis of this disease are controversial and inconclusive.<br /><strong>Objective:</stro...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Spanish |
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Centro Provincial de Información de Ciencias Médicas. Cienfuegos
2024-02-01
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| Series: | Medisur |
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| Online Access: | http://medisur.sld.cu/index.php/medisur/article/view/5873 |
| _version_ | 1797277665422475264 |
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| author | Marisol Peña Sánchez Cesarina Lisselotte Torres Vázquez Melany Betancourt Loza Alina González-Quevedo Monteagudo Marianela Arteche Prior María Caridad Menéndez Saiz |
| author_facet | Marisol Peña Sánchez Cesarina Lisselotte Torres Vázquez Melany Betancourt Loza Alina González-Quevedo Monteagudo Marianela Arteche Prior María Caridad Menéndez Saiz |
| author_sort | Marisol Peña Sánchez |
| collection | DOAJ |
| description | <p><strong>Foundation:</strong> High-sensitivity C-reactive protein and homocysteine seem to be related to ischemic cerebrovascular disease, but their findings on the risk and prognosis of this disease are controversial and inconclusive.<br /><strong>Objective:</strong> to characterize high sensitivity C-reactive protein and homocysteine in patients with ischemic cerebrovascular disease. <strong><br />Methods:</strong> a descriptive and retrospective cross-sectional study was carried out in patients with ischemic cerebrovascular disease, admitted to the Stroke Service of the Neurology and Neurosurgery Institute between 2016 and 2019. Demographic variables, clinical manifestations, time of evolution, etiology and infarction location, risk factors. High-sensitivity C-reactive protein (cardiovascular risk) and homocysteine were quantified.<br /><strong>Results:</strong> the means of C-reactive protein (7.0±8.3 mg/L) and homocysteine (17.1±7.3 µM) were high. Moderate and high cardiovascular risk occurred in equal proportions (46.8%). There were statistical differences in the relationship between cardiovascular risk and age (p=0.00); but neither the time of evolution nor the risk factors of the disease showed this behavior. Patients with high cardiovascular risk (hs-CRP >3 mg/L) and high homocysteine (>15 M), exhibited higher frequencies of atherothrombotic or cardioembolic etiologies.<br /><strong>Conclusions:</strong> cardiovascular risk increases as the age of patients with ischemic cerebrovascular disease increases. Demographic, clinical and neurological characteristics did not show a relationship with high cardiovascular risk and high homocysteine values, although an associative trend of atherothrombotic etiology was found with increased high-sensitivity C-reactive protein and homocysteine.</p> |
| first_indexed | 2024-03-07T15:52:35Z |
| format | Article |
| id | doaj.art-c1630ff06e9c4aa981fc70f9c8032e64 |
| institution | Directory Open Access Journal |
| issn | 1727-897X |
| language | Spanish |
| last_indexed | 2024-03-07T15:52:35Z |
| publishDate | 2024-02-01 |
| publisher | Centro Provincial de Información de Ciencias Médicas. Cienfuegos |
| record_format | Article |
| series | Medisur |
| spelling | doaj.art-c1630ff06e9c4aa981fc70f9c8032e642024-03-04T23:09:56ZspaCentro Provincial de Información de Ciencias Médicas. CienfuegosMedisur1727-897X2024-02-0122183932458High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular diseaseMarisol Peña Sánchez0Cesarina Lisselotte Torres Vázquez1Melany Betancourt Loza2Alina González-Quevedo Monteagudo3Marianela Arteche Prior4María Caridad Menéndez Saiz5Instituto de Neurología y Neurocirugía. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.Instituto de Neurología y Neurocirugía. La Habana, Cuba.<p><strong>Foundation:</strong> High-sensitivity C-reactive protein and homocysteine seem to be related to ischemic cerebrovascular disease, but their findings on the risk and prognosis of this disease are controversial and inconclusive.<br /><strong>Objective:</strong> to characterize high sensitivity C-reactive protein and homocysteine in patients with ischemic cerebrovascular disease. <strong><br />Methods:</strong> a descriptive and retrospective cross-sectional study was carried out in patients with ischemic cerebrovascular disease, admitted to the Stroke Service of the Neurology and Neurosurgery Institute between 2016 and 2019. Demographic variables, clinical manifestations, time of evolution, etiology and infarction location, risk factors. High-sensitivity C-reactive protein (cardiovascular risk) and homocysteine were quantified.<br /><strong>Results:</strong> the means of C-reactive protein (7.0±8.3 mg/L) and homocysteine (17.1±7.3 µM) were high. Moderate and high cardiovascular risk occurred in equal proportions (46.8%). There were statistical differences in the relationship between cardiovascular risk and age (p=0.00); but neither the time of evolution nor the risk factors of the disease showed this behavior. Patients with high cardiovascular risk (hs-CRP >3 mg/L) and high homocysteine (>15 M), exhibited higher frequencies of atherothrombotic or cardioembolic etiologies.<br /><strong>Conclusions:</strong> cardiovascular risk increases as the age of patients with ischemic cerebrovascular disease increases. Demographic, clinical and neurological characteristics did not show a relationship with high cardiovascular risk and high homocysteine values, although an associative trend of atherothrombotic etiology was found with increased high-sensitivity C-reactive protein and homocysteine.</p>http://medisur.sld.cu/index.php/medisur/article/view/5873accidente cerebrovascular isquémicoproteína c reactivahomocisteína |
| spellingShingle | Marisol Peña Sánchez Cesarina Lisselotte Torres Vázquez Melany Betancourt Loza Alina González-Quevedo Monteagudo Marianela Arteche Prior María Caridad Menéndez Saiz High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease Medisur accidente cerebrovascular isquémico proteína c reactiva homocisteína |
| title | High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease |
| title_full | High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease |
| title_fullStr | High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease |
| title_full_unstemmed | High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease |
| title_short | High sensitivity c-reactive protein and homocysteine in patients with ischemic cerebrovascular disease |
| title_sort | high sensitivity c reactive protein and homocysteine in patients with ischemic cerebrovascular disease |
| topic | accidente cerebrovascular isquémico proteína c reactiva homocisteína |
| url | http://medisur.sld.cu/index.php/medisur/article/view/5873 |
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