Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy
Background: To compare the intraoperative and postoperative outcomes of indocyanine green (ICG) administration in robot-assisted partial nephrectomy (RAPN) and report the differences in the results between patients with benign and malignant renal tumors. Methods: From 2017 to 2020, 132 patients unde...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Online Access: | https://www.mdpi.com/2072-6694/14/12/3032 |
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| author | Yu-Kuan Yang Ming-Li Hsieh Sy-Yuan Chen Chung-Yi Liu Po-Hung Lin Hung-Cheng Kan See-Tong Pang Kai-Jie Yu |
| author_facet | Yu-Kuan Yang Ming-Li Hsieh Sy-Yuan Chen Chung-Yi Liu Po-Hung Lin Hung-Cheng Kan See-Tong Pang Kai-Jie Yu |
| author_sort | Yu-Kuan Yang |
| collection | DOAJ |
| description | Background: To compare the intraoperative and postoperative outcomes of indocyanine green (ICG) administration in robot-assisted partial nephrectomy (RAPN) and report the differences in the results between patients with benign and malignant renal tumors. Methods: From 2017 to 2020, 132 patients underwent RAPN at our institution, including 21 patients with ICG administration. Clinical data obtained from our institution’s RAPN database were retrospectively reviewed. Intraoperative, postoperative, pathological, and functional outcomes of RAPN were assessed. Results: The pathological results indicated that among the 127 patients, 38 and 89 had received diagnoses of benign and malignant tumors, respectively. A longer operative time (311 vs. 271 min; <i>p</i> = 0.006) but superior preservation of estimated glomerular filtration rate (eGFR) at 3-month follow-up (90% vs. 85%; <i>p</i> = 0.031) were observed in the ICG-RAPN group. Less estimated blood loss, shorter warm ischemia time, and superior preservation of eGFR at postoperative day 1 and 6-month follow-up were also noted, despite no significant differences. Among the patients with malignant tumors, less estimated blood loss (30 vs. 100 mL; <i>p</i> < 0.001) was reported in the ICG-RAPN subgroup. Conclusions: Patients with ICG-RAPN exhibited superior short-term renal function outcomes compared with the standard RAPN group. Of the patients with malignant tumors, ICG-RAPN was associated with less blood loss than standard RAPN without a more positive margin rate. Further studies with larger cohorts and prospective designs are necessary to verify the intraoperative and functional advantages of the green dye. |
| first_indexed | 2024-03-10T00:12:23Z |
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| id | doaj.art-c165cfd8d7d245b486956b9f10b5e3da |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:12:23Z |
| publishDate | 2022-06-01 |
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| series | Cancers |
| spelling | doaj.art-c165cfd8d7d245b486956b9f10b5e3da2023-11-23T15:58:16ZengMDPI AGCancers2072-66942022-06-011412303210.3390/cancers14123032Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial NephrectomyYu-Kuan Yang0Ming-Li Hsieh1Sy-Yuan Chen2Chung-Yi Liu3Po-Hung Lin4Hung-Cheng Kan5See-Tong Pang6Kai-Jie Yu7Division of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDivision of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDivision of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanCollege of Medicine, Graduate Institute of Clinical Medical Sciences, Chang Gung University, Taoyuan 333, TaiwanDivision of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDivision of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDivision of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDivision of Urology, Department of Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan 333, TaiwanBackground: To compare the intraoperative and postoperative outcomes of indocyanine green (ICG) administration in robot-assisted partial nephrectomy (RAPN) and report the differences in the results between patients with benign and malignant renal tumors. Methods: From 2017 to 2020, 132 patients underwent RAPN at our institution, including 21 patients with ICG administration. Clinical data obtained from our institution’s RAPN database were retrospectively reviewed. Intraoperative, postoperative, pathological, and functional outcomes of RAPN were assessed. Results: The pathological results indicated that among the 127 patients, 38 and 89 had received diagnoses of benign and malignant tumors, respectively. A longer operative time (311 vs. 271 min; <i>p</i> = 0.006) but superior preservation of estimated glomerular filtration rate (eGFR) at 3-month follow-up (90% vs. 85%; <i>p</i> = 0.031) were observed in the ICG-RAPN group. Less estimated blood loss, shorter warm ischemia time, and superior preservation of eGFR at postoperative day 1 and 6-month follow-up were also noted, despite no significant differences. Among the patients with malignant tumors, less estimated blood loss (30 vs. 100 mL; <i>p</i> < 0.001) was reported in the ICG-RAPN subgroup. Conclusions: Patients with ICG-RAPN exhibited superior short-term renal function outcomes compared with the standard RAPN group. Of the patients with malignant tumors, ICG-RAPN was associated with less blood loss than standard RAPN without a more positive margin rate. Further studies with larger cohorts and prospective designs are necessary to verify the intraoperative and functional advantages of the green dye.https://www.mdpi.com/2072-6694/14/12/3032robot-assisted partial nephrectomyrenal cell carcinomaindocyanine greennephron sparing |
| spellingShingle | Yu-Kuan Yang Ming-Li Hsieh Sy-Yuan Chen Chung-Yi Liu Po-Hung Lin Hung-Cheng Kan See-Tong Pang Kai-Jie Yu Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy Cancers robot-assisted partial nephrectomy renal cell carcinoma indocyanine green nephron sparing |
| title | Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy |
| title_full | Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy |
| title_fullStr | Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy |
| title_full_unstemmed | Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy |
| title_short | Clinical Benefits of Indocyanine Green Fluorescence in Robot-Assisted Partial Nephrectomy |
| title_sort | clinical benefits of indocyanine green fluorescence in robot assisted partial nephrectomy |
| topic | robot-assisted partial nephrectomy renal cell carcinoma indocyanine green nephron sparing |
| url | https://www.mdpi.com/2072-6694/14/12/3032 |
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