White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia
Background: Violent acts in patients with schizophrenia are often associated with their hostility and aggression levels. Poor visuospatial processing has been suggested as a possible risk factor of violence in schizophrenia. However, studies investigating the relationship between hostility, aggressi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.734488/full |
| _version_ | 1819132013327679488 |
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| author | Iseul An Tai Kiu Choi Tai Kiu Choi Minji Bang Sang-Hyuk Lee Sang-Hyuk Lee |
| author_facet | Iseul An Tai Kiu Choi Tai Kiu Choi Minji Bang Sang-Hyuk Lee Sang-Hyuk Lee |
| author_sort | Iseul An |
| collection | DOAJ |
| description | Background: Violent acts in patients with schizophrenia are often associated with their hostility and aggression levels. Poor visuospatial processing has been suggested as a possible risk factor of violence in schizophrenia. However, studies investigating the relationship between hostility, aggression, and the visuospatial function have been lacking. Here, we aimed to investigate brain dysconnectivity associated with hostility and aggression in schizophrenia, particularly focusing on the visuospatial function network.Methods: Eighty-eight participants with schizophrenia and 42 healthy controls were enrolled. The visuospatial function network regions of interest were analyzed using Tract-Based Spatial Statistics. The hostility item from the Positive and Negative Syndrome Scale (PANSS), aggressive, and agitated behavior item from the Scale for the Assessment of Positive Symptoms (SAPS), and the Rey Complex Figure Test (R-CFT) were measured.Results: Among the participants with schizophrenia, the SAPS aggressive and agitated behavior scores were significantly correlated with fractional anisotropies (FAs) of the white matter regions in the splenium of the corpus callosum (CC), left posterior thalamic radiations (PTR), and left posterior corona radiata (PCR). Exploratory correlational analysis revealed significant negative correlations between FAs of the splenium of the CC and R-CFT copy and immediate recall scores. In addition, three regions including CC, PTR, and PCR that significantly correlated with the aggression scores showed significant correlations with the total PANSS scores.Conclusion: Our main finding suggests that aggression of patients with schizophrenia may be associated with poor visuospatial ability and underlying white matter dysconnectivity. These may help enhance understanding aggression in patients with schizophrenia. |
| first_indexed | 2024-12-22T09:24:39Z |
| format | Article |
| id | doaj.art-c166ff81e0bd4769baf3870393b69c85 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T09:24:39Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-c166ff81e0bd4769baf3870393b69c852022-12-21T18:31:07ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-10-011210.3389/fpsyt.2021.734488734488White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With SchizophreniaIseul An0Tai Kiu Choi1Tai Kiu Choi2Minji Bang3Sang-Hyuk Lee4Sang-Hyuk Lee5Department of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South KoreaDepartment of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South KoreaClinical Counseling Psychology Graduate School, CHA University, Seongnam, South KoreaDepartment of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South KoreaDepartment of Psychiatry, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South KoreaDepartment of Clinical Pharmacology and Therapeutics, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South KoreaBackground: Violent acts in patients with schizophrenia are often associated with their hostility and aggression levels. Poor visuospatial processing has been suggested as a possible risk factor of violence in schizophrenia. However, studies investigating the relationship between hostility, aggression, and the visuospatial function have been lacking. Here, we aimed to investigate brain dysconnectivity associated with hostility and aggression in schizophrenia, particularly focusing on the visuospatial function network.Methods: Eighty-eight participants with schizophrenia and 42 healthy controls were enrolled. The visuospatial function network regions of interest were analyzed using Tract-Based Spatial Statistics. The hostility item from the Positive and Negative Syndrome Scale (PANSS), aggressive, and agitated behavior item from the Scale for the Assessment of Positive Symptoms (SAPS), and the Rey Complex Figure Test (R-CFT) were measured.Results: Among the participants with schizophrenia, the SAPS aggressive and agitated behavior scores were significantly correlated with fractional anisotropies (FAs) of the white matter regions in the splenium of the corpus callosum (CC), left posterior thalamic radiations (PTR), and left posterior corona radiata (PCR). Exploratory correlational analysis revealed significant negative correlations between FAs of the splenium of the CC and R-CFT copy and immediate recall scores. In addition, three regions including CC, PTR, and PCR that significantly correlated with the aggression scores showed significant correlations with the total PANSS scores.Conclusion: Our main finding suggests that aggression of patients with schizophrenia may be associated with poor visuospatial ability and underlying white matter dysconnectivity. These may help enhance understanding aggression in patients with schizophrenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.734488/fullschizophreniaaggressionvisuospatialbrain imaging (MRI)white matter connectivity |
| spellingShingle | Iseul An Tai Kiu Choi Tai Kiu Choi Minji Bang Sang-Hyuk Lee Sang-Hyuk Lee White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia Frontiers in Psychiatry schizophrenia aggression visuospatial brain imaging (MRI) white matter connectivity |
| title | White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia |
| title_full | White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia |
| title_fullStr | White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia |
| title_full_unstemmed | White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia |
| title_short | White Matter Correlates of Hostility and Aggression in the Visuospatial Function Network in Patients With Schizophrenia |
| title_sort | white matter correlates of hostility and aggression in the visuospatial function network in patients with schizophrenia |
| topic | schizophrenia aggression visuospatial brain imaging (MRI) white matter connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.734488/full |
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