Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2
The healthcare-associated infections (HAIs) and pandemics caused by multidrug-resistant (MDR) and new-generation pathogens threaten the whole world community. Cu and its alloys have been attracting widespread interest as anti-contamination materials due to the rapid inactivation of MDR-superbugs and...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024042695 |
| _version_ | 1827293947484962816 |
|---|---|
| author | L. Lorenzetti M. Brandolini G. Gatti E. Bernardi C. Chiavari P. Gualandi G. Galliani V. Sambri C. Martini |
| author_facet | L. Lorenzetti M. Brandolini G. Gatti E. Bernardi C. Chiavari P. Gualandi G. Galliani V. Sambri C. Martini |
| author_sort | L. Lorenzetti |
| collection | DOAJ |
| description | The healthcare-associated infections (HAIs) and pandemics caused by multidrug-resistant (MDR) and new-generation pathogens threaten the whole world community. Cu and its alloys have been attracting widespread interest as anti-contamination materials due to the rapid inactivation of MDR-superbugs and viruses. Applying thin Cu-based foils on pre-existing surfaces in hygiene-sensitive areas represents a quick, simple, cost-effective self-sanitising practice. However, the influence of chemical composition and microstructure should be deeply investigated when evaluating the antimicrobial capability and durability of Cu-based materials. The effect of composition on micromechanical and antiviral properties was investigated by comparing Cu15Zn and Cu18Ni20Zn (foil thickness from 13 to 27 μm) with Phosphorous High-Conductivity (PHC) Cu. The influence of recrystallisation annealing of PHC Cu was also investigated. Microstructural characterisation was carried out by optical (OM) and scanning electron (FEG-SEM) microscopy, Energy-dispersive Spectroscopy (EDS) and Electron-Backscattered Diffraction (EBSD). The micromechanical behaviour was assessed by microhardness, microscale abrasion and scratch tests. Cu-based foils were exposed to SARS-CoV-2 for different time points in quasi-dry conditions (artificial sweat solution), evaluating their antiviral capability by quantitative Reverse-Transcriptase Polymerase Chain Reaction (qRT-PCR). Surface morphology, contact angle measurements and Cu release were measured. All Cu-based surfaces completely inactivated SARS-CoV-2 in 10 min: pure Cu was the best option regarding antiviral efficiency, while Cu15Zn showed the best trade-off between micromechanical and antiviral properties. |
| first_indexed | 2024-04-24T13:48:36Z |
| format | Article |
| id | doaj.art-c16770b1a21043859014051244d5bc9f |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-24T13:48:36Z |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-c16770b1a21043859014051244d5bc9f2024-04-04T05:07:03ZengElsevierHeliyon2405-84402024-03-01106e28238Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2L. Lorenzetti0M. Brandolini1G. Gatti2E. Bernardi3C. Chiavari4P. Gualandi5G. Galliani6V. Sambri7C. Martini8Dept. Industrial Engineering (DIN), University of Bologna, Viale Risorgimento 4, 40136 Bologna, Italy; Corresponding author. Department of Industrial Engineering, Alma Mater Studiorum, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy.Unit of Microbiology, The Great Romagna Hub Laboratory, Piazza della Liberazione 60, 47522 Pievesestina, Italy; Dept. Medical and Surgical Sciences (DIMEC), University of Bologna, Via Irnerio 49, 40126 Bologna, ItalyUnit of Microbiology, The Great Romagna Hub Laboratory, Piazza della Liberazione 60, 47522 Pievesestina, Italy; Dept. Medical and Surgical Sciences (DIMEC), University of Bologna, Via Irnerio 49, 40126 Bologna, ItalyDept. Industrial Chemistry ''Toso Montanari'', University of Bologna, Via Piero Gobetti 85, Bologna 40129, ItalyDept. Cultural Heritage (DBC), University of Bologna, Via degli Ariani 1, 48121 Ravenna, ItalyPietro Galliani SpA, Via Molino Malpasso 65, 40038 Vergato (BO), ItalyPietro Galliani SpA, Via Molino Malpasso 65, 40038 Vergato (BO), ItalyUnit of Microbiology, The Great Romagna Hub Laboratory, Piazza della Liberazione 60, 47522 Pievesestina, Italy; Dept. Medical and Surgical Sciences (DIMEC), University of Bologna, Via Irnerio 49, 40126 Bologna, ItalyDept. Industrial Engineering (DIN), University of Bologna, Viale Risorgimento 4, 40136 Bologna, ItalyThe healthcare-associated infections (HAIs) and pandemics caused by multidrug-resistant (MDR) and new-generation pathogens threaten the whole world community. Cu and its alloys have been attracting widespread interest as anti-contamination materials due to the rapid inactivation of MDR-superbugs and viruses. Applying thin Cu-based foils on pre-existing surfaces in hygiene-sensitive areas represents a quick, simple, cost-effective self-sanitising practice. However, the influence of chemical composition and microstructure should be deeply investigated when evaluating the antimicrobial capability and durability of Cu-based materials. The effect of composition on micromechanical and antiviral properties was investigated by comparing Cu15Zn and Cu18Ni20Zn (foil thickness from 13 to 27 μm) with Phosphorous High-Conductivity (PHC) Cu. The influence of recrystallisation annealing of PHC Cu was also investigated. Microstructural characterisation was carried out by optical (OM) and scanning electron (FEG-SEM) microscopy, Energy-dispersive Spectroscopy (EDS) and Electron-Backscattered Diffraction (EBSD). The micromechanical behaviour was assessed by microhardness, microscale abrasion and scratch tests. Cu-based foils were exposed to SARS-CoV-2 for different time points in quasi-dry conditions (artificial sweat solution), evaluating their antiviral capability by quantitative Reverse-Transcriptase Polymerase Chain Reaction (qRT-PCR). Surface morphology, contact angle measurements and Cu release were measured. All Cu-based surfaces completely inactivated SARS-CoV-2 in 10 min: pure Cu was the best option regarding antiviral efficiency, while Cu15Zn showed the best trade-off between micromechanical and antiviral properties.http://www.sciencedirect.com/science/article/pii/S2405844024042695Respiratory tract infectionsCu-based thin foilsHigh-touch surfacesMicrostructureMicromechanical propertiesAntiviral efficiency (vs SARS-CoV-2) |
| spellingShingle | L. Lorenzetti M. Brandolini G. Gatti E. Bernardi C. Chiavari P. Gualandi G. Galliani V. Sambri C. Martini Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2 Heliyon Respiratory tract infections Cu-based thin foils High-touch surfaces Microstructure Micromechanical properties Antiviral efficiency (vs SARS-CoV-2) |
| title | Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2 |
| title_full | Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2 |
| title_fullStr | Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2 |
| title_full_unstemmed | Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2 |
| title_short | Cu-based thin rolled foils: relationship among alloy composition, micromechanical and antiviral properties against SARS-CoV-2 |
| title_sort | cu based thin rolled foils relationship among alloy composition micromechanical and antiviral properties against sars cov 2 |
| topic | Respiratory tract infections Cu-based thin foils High-touch surfaces Microstructure Micromechanical properties Antiviral efficiency (vs SARS-CoV-2) |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024042695 |
| work_keys_str_mv | AT llorenzetti cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT mbrandolini cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT ggatti cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT ebernardi cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT cchiavari cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT pgualandi cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT ggalliani cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT vsambri cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 AT cmartini cubasedthinrolledfoilsrelationshipamongalloycompositionmicromechanicalandantiviralpropertiesagainstsarscov2 |