Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report
Introduction. Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory state mediated by uncontrolled cytokine storm and haemophagocytosis. Although rarely reported, MAS might occur in systemic lupus erythematosus (SLE), notably as an inaugural manifestation. Glucocorticoids (GCs...
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| Format: | Article |
| Language: | English |
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Sciendo
2018-03-01
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| Series: | Romanian Journal of Internal Medicine |
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| Online Access: | https://doi.org/10.1515/rjim-2017-0035 |
| _version_ | 1828332686560722944 |
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| author | Tulbă Delia Balea Marius Băicuş Cristian |
| author_facet | Tulbă Delia Balea Marius Băicuş Cristian |
| author_sort | Tulbă Delia |
| collection | DOAJ |
| description | Introduction. Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory state mediated by uncontrolled cytokine storm and haemophagocytosis. Although rarely reported, MAS might occur in systemic lupus erythematosus (SLE), notably as an inaugural manifestation. Glucocorticoids (GCs) are the cornerstone of SLE therapy. However, in some cases high doses of GCs are required to achieve remission (i.e. glucocorticoid-resistance), leading to significant side effects. |
| first_indexed | 2024-04-13T21:09:42Z |
| format | Article |
| id | doaj.art-c16874715b4c4eeb9779291b3b06446c |
| institution | Directory Open Access Journal |
| issn | 2501-062X |
| language | English |
| last_indexed | 2024-04-13T21:09:42Z |
| publishDate | 2018-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Internal Medicine |
| spelling | doaj.art-c16874715b4c4eeb9779291b3b06446c2022-12-22T02:29:51ZengSciendoRomanian Journal of Internal Medicine2501-062X2018-03-01561677010.1515/rjim-2017-0035rjim-2017-0035Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case reportTulbă Delia0Balea Marius1Băicuş Cristian2Internal Medicine Department, “Colentina” Clinical Hospital, Bucharest, RomaniaHematology Department, “Colentina” Clinical Hospital, Bucharest, RomaniaInternal Medicine Department, “Colentina” Clinical Hospital, Bucharest, RomaniaIntroduction. Macrophage activation syndrome (MAS) is a life-threatening hyperinflammatory state mediated by uncontrolled cytokine storm and haemophagocytosis. Although rarely reported, MAS might occur in systemic lupus erythematosus (SLE), notably as an inaugural manifestation. Glucocorticoids (GCs) are the cornerstone of SLE therapy. However, in some cases high doses of GCs are required to achieve remission (i.e. glucocorticoid-resistance), leading to significant side effects.https://doi.org/10.1515/rjim-2017-0035macrophage activation syndromesystemic lupus erythematosushyperferritinemiaglucocorticoid-resistancehigh-dose corticotherapy |
| spellingShingle | Tulbă Delia Balea Marius Băicuş Cristian Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report Romanian Journal of Internal Medicine macrophage activation syndrome systemic lupus erythematosus hyperferritinemia glucocorticoid-resistance high-dose corticotherapy |
| title | Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report |
| title_full | Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report |
| title_fullStr | Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report |
| title_full_unstemmed | Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report |
| title_short | Macrophage activation syndrome at the onset of glucocorticoid-resistant systemic lupus erythematosus: a case report |
| title_sort | macrophage activation syndrome at the onset of glucocorticoid resistant systemic lupus erythematosus a case report |
| topic | macrophage activation syndrome systemic lupus erythematosus hyperferritinemia glucocorticoid-resistance high-dose corticotherapy |
| url | https://doi.org/10.1515/rjim-2017-0035 |
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