Histological and Morphometrical Studies in Liver Regeneration in Mice
Liver regeneration after loss of important cell population is a complex process involving all mature liver cell types. We study the response of hepatocytes in 24h and 48h after partial hepatectomy by microscopic and morphometric analysis. Thirty adult male NMRI, 8 week old mice were used in the stud...
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| Format: | Article |
| Language: | English |
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Agroprint Timisoara
2023-09-01
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| Series: | Scientific Papers Animal Science and Biotechnologies |
| Subjects: | |
| Online Access: | https://spasb.ro/index.php/public_html/article/view/696 |
| _version_ | 1827288333315735552 |
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| author | Roxana Popescu Marioara Nicoleta Filimon Gabi Dumitrescu Liliana Petculescu-Ciochina Victor Dumitrascu Daliborca Vlad Doina Verdes |
| author_facet | Roxana Popescu Marioara Nicoleta Filimon Gabi Dumitrescu Liliana Petculescu-Ciochina Victor Dumitrascu Daliborca Vlad Doina Verdes |
| author_sort | Roxana Popescu |
| collection | DOAJ |
| description | Liver regeneration after loss of important cell population is a complex process involving all mature liver cell types. We study the response of hepatocytes in 24h and 48h after partial hepatectomy by microscopic and morphometric analysis. Thirty adult male NMRI, 8 week old mice were used in the study. Liver regeneration after partial hepatectomy (68%) in mice is a complex process that is performed on account differentiated mature hepatocyte proliferation, as evidenced by the presence of nuclei hypertrophy, binucleate cells or polyploidy, and numerous mitotic figures. Morphometrical analysis of cell size showed increases in average dimension of the control compared to the experimental groups. After this study, we can conclude that liver regeneration after partial hepatectomy is marked by the proliferation of liver cell population, while reducing the apoptotic process. |
| first_indexed | 2024-04-24T11:29:13Z |
| format | Article |
| id | doaj.art-c16b6a680ed6499d9c422a9f3a7380c1 |
| institution | Directory Open Access Journal |
| issn | 1841-9364 2344-4576 |
| language | English |
| last_indexed | 2024-04-24T11:29:13Z |
| publishDate | 2023-09-01 |
| publisher | Agroprint Timisoara |
| record_format | Article |
| series | Scientific Papers Animal Science and Biotechnologies |
| spelling | doaj.art-c16b6a680ed6499d9c422a9f3a7380c12024-04-10T11:07:19ZengAgroprint TimisoaraScientific Papers Animal Science and Biotechnologies1841-93642344-45762023-09-01452203203696Histological and Morphometrical Studies in Liver Regeneration in MiceRoxana Popescu0Marioara Nicoleta Filimon1Gabi Dumitrescu2Liliana Petculescu-Ciochina3Victor Dumitrascu4Daliborca Vlad5Doina Verdes6University of Medicine and Pharmacy “Victor Babes” Timisoara, Department of Cellular and Molecular Biology,300041, 2 Eftimie Murgu Street, RomaniaWest University of Timisoara, Faculty of Chemistry-Biology-Geography, Department of Biology, 300115, 16 Pestalozzy Street RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Animal Science and Biotechnology, 300645, Timişoara, C. Aradului 119, RomaniaBanat’s University of Agricultural Sciences and Veterinary Medicine, Faculty of Animal Science and Biotechnology, 300645, Timişoara, C. Aradului 119, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, Department of Pharmacology, 300041, 2 Eftimie Murgu Street, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, Department of Pharmacology, 300041, 2 Eftimie Murgu Street, RomaniaUniversity of Medicine and Pharmacy “Victor Babes” Timisoara, Department of Pharmacology, 300041, 2 Eftimie Murgu Street, RomaniaLiver regeneration after loss of important cell population is a complex process involving all mature liver cell types. We study the response of hepatocytes in 24h and 48h after partial hepatectomy by microscopic and morphometric analysis. Thirty adult male NMRI, 8 week old mice were used in the study. Liver regeneration after partial hepatectomy (68%) in mice is a complex process that is performed on account differentiated mature hepatocyte proliferation, as evidenced by the presence of nuclei hypertrophy, binucleate cells or polyploidy, and numerous mitotic figures. Morphometrical analysis of cell size showed increases in average dimension of the control compared to the experimental groups. After this study, we can conclude that liver regeneration after partial hepatectomy is marked by the proliferation of liver cell population, while reducing the apoptotic process.https://spasb.ro/index.php/public_html/article/view/696histologyliver regenerationmorphometry |
| spellingShingle | Roxana Popescu Marioara Nicoleta Filimon Gabi Dumitrescu Liliana Petculescu-Ciochina Victor Dumitrascu Daliborca Vlad Doina Verdes Histological and Morphometrical Studies in Liver Regeneration in Mice Scientific Papers Animal Science and Biotechnologies histology liver regeneration morphometry |
| title | Histological and Morphometrical Studies in Liver Regeneration in Mice |
| title_full | Histological and Morphometrical Studies in Liver Regeneration in Mice |
| title_fullStr | Histological and Morphometrical Studies in Liver Regeneration in Mice |
| title_full_unstemmed | Histological and Morphometrical Studies in Liver Regeneration in Mice |
| title_short | Histological and Morphometrical Studies in Liver Regeneration in Mice |
| title_sort | histological and morphometrical studies in liver regeneration in mice |
| topic | histology liver regeneration morphometry |
| url | https://spasb.ro/index.php/public_html/article/view/696 |
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