s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight
Background and aims: to estimate concentration of sMadCAM-1 in peripheral blood at patients with chronic hepatitis C with excess body weight.Materials and methods: The research included 88 patients (67 men, 21 women 41.4±3.2 years of age) with chronic hepatitis C (CHC) and excess body weight (the in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Journal Infectology
2019-05-01
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| Series: | Журнал инфектологии |
| Subjects: | |
| Online Access: | https://journal.niidi.ru/jofin/article/view/885 |
| _version_ | 1826557860314611712 |
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| author | K. V. Zhdanov A. V. Semenov S. S. Karyakin K. V. Kozlov V. S. Sukachev Yu. V. Ostankova D. E. Valutite E. B. Zueva R. S. Sidorov A. V. Saulevich Yu. I. Bulan’kov Yu. I. Lyashenko K. S. Ivanov |
| author_facet | K. V. Zhdanov A. V. Semenov S. S. Karyakin K. V. Kozlov V. S. Sukachev Yu. V. Ostankova D. E. Valutite E. B. Zueva R. S. Sidorov A. V. Saulevich Yu. I. Bulan’kov Yu. I. Lyashenko K. S. Ivanov |
| author_sort | K. V. Zhdanov |
| collection | DOAJ |
| description | Background and aims: to estimate concentration of sMadCAM-1 in peripheral blood at patients with chronic hepatitis C with excess body weight.Materials and methods: The research included 88 patients (67 men, 21 women 41.4±3.2 years of age) with chronic hepatitis C (CHC) and excess body weight (the index of body mass is ³25 kg/m2, and abdominal circumference more than 94 cm in men, and 80 cm in women) with various morfofunktsionalny changes in a liver and a small bowel. From them men there were 67 people, women – 21, middle age was 41.4±3.2 years.To all the patients complex clinical, biochemical, virologic, morphological trial was carried out. The functional condition of intestines was estimated by identification of a small intestinal bacterial overgrowth (SIBO) when carrying out the hydrogen respiratory test (HRT) with lactulose and existence of endoscopic signs of inflammation of a mucous membrane of intestines at a fibroezofagogastroduodenoskopiya. The quantitative assessment of a mucosal addressin cell adhesion molecule -1 was carried out by the definition concentration of its soluble form (sMadCAM-1) in a blood plasma by enzyme immunoassay method.Results: the sMadCAM-1 level of peripheral blood at the patients with excess body weight increased in process of progressing of a stage of chronic hepatitis C (F0 – 349.10 (324.27-373.92) ng/ml; F1/2 – 439.69 (406.43-472.94) ng/ml; F3/4 – 1057.82 (593.38-1522.26) ng/ml; p˂0.05), existence of a syndrome of excess bacterial growth and endoscopic signsof a duodenitis. Besides, patients had its concentration more with the biochemical signs characterizing cytolytic (at ALT˃N: 502.54 (432.04-573.03) ng/ml against 381.04(345.49-416.58) at the ALT normal values), cholestatic (at GGTP˃N: 550.59 (453.31-647.88) ng/ml against 400.86(365.13-436.59) atnormal GGTP, p values 0.05; at ALP N: 572.2 (353.7-790.8) ng/ml against 468.7 (408.5-528.9) ng/ml at normal ALP, p values 0.05) and metabolic syndromes (at glucose of blood, TG, VLDL N: 562.93 (369.59-756.27) ng/ml, 681.15 (387.81-974.49) ng/ml, 809.65(124.04-1495.28) against (438.34(391.36-485.31) ng/ml), (421.69(379.41-463.97) ng/ml), 434.47(389.45-479.48), p values 0.05 at normal values of these indicators respectively). Conclusion: Progressing of fibrosis and functional disturbances in intestines are interconnected with increase in concentration of MadCAM-1 in blood that allows to consider pathological changes in intestines of various genesis as the accessory factor promoting progressing of СHC at patients with excess body weight. Besides, definition of concentration of sMadCAM-1 in peripheral blood can be used as one of markers of noninvasive diagnostics of a stage of fibrosis at the patients with СHC and excess body weight. |
| first_indexed | 2024-03-12T04:53:11Z |
| format | Article |
| id | doaj.art-c16bdfe08fdd44bca64fbb91abfd12c6 |
| institution | Directory Open Access Journal |
| issn | 2072-6732 |
| language | Russian |
| last_indexed | 2025-03-14T08:35:18Z |
| publishDate | 2019-05-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj.art-c16bdfe08fdd44bca64fbb91abfd12c62025-03-02T13:00:31ZrusJournal InfectologyЖурнал инфектологии2072-67322019-05-01112637010.22625/2072-6732-2019-11-2-63-70723s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weightK. V. Zhdanov0A. V. Semenov1S. S. Karyakin2K. V. Kozlov3V. S. Sukachev4Yu. V. Ostankova5D. E. Valutite6E. B. Zueva7R. S. Sidorov8A. V. Saulevich9Yu. I. Bulan’kov10Yu. I. Lyashenko11K. S. Ivanov12Military Medical Academy named after S.M. KirovScience Research Institute of Epidemiology and Microbiology named after PasteurMilitary Medical Academy named after S.M. KirovMilitary Medical Academy named after S.M. KirovMilitary Medical Academy named after S.M. KirovScience Research Institute of Epidemiology and Microbiology named after PasteurScience Research Institute of Epidemiology and Microbiology named after PasteurScience Research Institute of Epidemiology and Microbiology named after PasteurCenter for Prevention and Control of AIDS and Infectious DiseasesMilitary Medical Academy named after S.M. KirovMilitary Medical Academy named after S.M. KirovMilitary Medical Academy named after S.M. KirovMilitary Medical Academy named after S.M. KirovBackground and aims: to estimate concentration of sMadCAM-1 in peripheral blood at patients with chronic hepatitis C with excess body weight.Materials and methods: The research included 88 patients (67 men, 21 women 41.4±3.2 years of age) with chronic hepatitis C (CHC) and excess body weight (the index of body mass is ³25 kg/m2, and abdominal circumference more than 94 cm in men, and 80 cm in women) with various morfofunktsionalny changes in a liver and a small bowel. From them men there were 67 people, women – 21, middle age was 41.4±3.2 years.To all the patients complex clinical, biochemical, virologic, morphological trial was carried out. The functional condition of intestines was estimated by identification of a small intestinal bacterial overgrowth (SIBO) when carrying out the hydrogen respiratory test (HRT) with lactulose and existence of endoscopic signs of inflammation of a mucous membrane of intestines at a fibroezofagogastroduodenoskopiya. The quantitative assessment of a mucosal addressin cell adhesion molecule -1 was carried out by the definition concentration of its soluble form (sMadCAM-1) in a blood plasma by enzyme immunoassay method.Results: the sMadCAM-1 level of peripheral blood at the patients with excess body weight increased in process of progressing of a stage of chronic hepatitis C (F0 – 349.10 (324.27-373.92) ng/ml; F1/2 – 439.69 (406.43-472.94) ng/ml; F3/4 – 1057.82 (593.38-1522.26) ng/ml; p˂0.05), existence of a syndrome of excess bacterial growth and endoscopic signsof a duodenitis. Besides, patients had its concentration more with the biochemical signs characterizing cytolytic (at ALT˃N: 502.54 (432.04-573.03) ng/ml against 381.04(345.49-416.58) at the ALT normal values), cholestatic (at GGTP˃N: 550.59 (453.31-647.88) ng/ml against 400.86(365.13-436.59) atnormal GGTP, p values 0.05; at ALP N: 572.2 (353.7-790.8) ng/ml against 468.7 (408.5-528.9) ng/ml at normal ALP, p values 0.05) and metabolic syndromes (at glucose of blood, TG, VLDL N: 562.93 (369.59-756.27) ng/ml, 681.15 (387.81-974.49) ng/ml, 809.65(124.04-1495.28) against (438.34(391.36-485.31) ng/ml), (421.69(379.41-463.97) ng/ml), 434.47(389.45-479.48), p values 0.05 at normal values of these indicators respectively). Conclusion: Progressing of fibrosis and functional disturbances in intestines are interconnected with increase in concentration of MadCAM-1 in blood that allows to consider pathological changes in intestines of various genesis as the accessory factor promoting progressing of СHC at patients with excess body weight. Besides, definition of concentration of sMadCAM-1 in peripheral blood can be used as one of markers of noninvasive diagnostics of a stage of fibrosis at the patients with СHC and excess body weight.https://journal.niidi.ru/jofin/article/view/885hepatitis cexcess body weightsmall intestinal bacterial overgrowthliver fibrosisliver steatosismucosal addressin cell adhesion molecule -1 |
| spellingShingle | K. V. Zhdanov A. V. Semenov S. S. Karyakin K. V. Kozlov V. S. Sukachev Yu. V. Ostankova D. E. Valutite E. B. Zueva R. S. Sidorov A. V. Saulevich Yu. I. Bulan’kov Yu. I. Lyashenko K. S. Ivanov s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight Журнал инфектологии hepatitis c excess body weight small intestinal bacterial overgrowth liver fibrosis liver steatosis mucosal addressin cell adhesion molecule -1 |
| title | s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight |
| title_full | s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight |
| title_fullStr | s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight |
| title_full_unstemmed | s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight |
| title_short | s MadCAM-1 as an immunological marker in the «gut liver axis» at patients with chronic hepatitis C and excess body weight |
| title_sort | s madcam 1 as an immunological marker in the gut liver axis at patients with chronic hepatitis c and excess body weight |
| topic | hepatitis c excess body weight small intestinal bacterial overgrowth liver fibrosis liver steatosis mucosal addressin cell adhesion molecule -1 |
| url | https://journal.niidi.ru/jofin/article/view/885 |
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