Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis
BackgroundProline metabolism is closely related to the occurrence and development of cancer. Δ1-Pyrroline-5-carboxylate reductase (PYCR) is the last enzyme in proline biosynthesis. As one of the enzyme types, PYCR1 takes part in the whole process of the growth, invasion, and drug resistance of cance...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.985613/full |
| _version_ | 1798024628536344576 |
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| author | Yue Li Jiahuan Xu Pengchen Bao Zhijing Wei Lei Pan Jiawei Zhou Wei Wang |
| author_facet | Yue Li Jiahuan Xu Pengchen Bao Zhijing Wei Lei Pan Jiawei Zhou Wei Wang |
| author_sort | Yue Li |
| collection | DOAJ |
| description | BackgroundProline metabolism is closely related to the occurrence and development of cancer. Δ1-Pyrroline-5-carboxylate reductase (PYCR) is the last enzyme in proline biosynthesis. As one of the enzyme types, PYCR1 takes part in the whole process of the growth, invasion, and drug resistance of cancer cells. This study investigated PYCR1 expressions in cancers together with their relationship to clinical prognosis.MethodsA thorough database search was performed in PubMed, EMBASE, and Cochrane Library. RevMan5.3 software was used for the statistical analysis.ResultsEight articles were selected, and 728 cancer patients were enrolled. The cancer types include lung, stomach, pancreatic ductal adenocarcinoma, hepatocellular carcinoma, and renal cell carcinoma. The meta-analysis results showed that the expression of PYCR1 was higher in the clinical stage III–IV group than that in the clinical stage I–II group (OR = 1.67, 95%CI: 1.03–2.71), higher in the lymph node metastasis group than in the non-lymph node metastasis group (OR = 1.57, 95%CI: 1.06–2.33), and higher in the distant metastasis group than in the non-distant metastasis group (OR = 3.46, 95%CI: 1.64–7.29). However, there was no statistical difference in PYCR1 expression between different tumor sizes (OR = 1.50, 95%CI: 0.89–2.53) and degrees of differentiation (OR = 0.82, 95%CI: 0.54–1.24).ConclusionPYCR1 had a high expression in various cancers and was associated with cancer volume and metastasis. The higher the PYCR1 expression was, the poorer the cancer prognosis was. The molecular events and biological processes mediated by PYCR1 might be the underlying mechanisms of metastasis. |
| first_indexed | 2024-04-11T18:05:40Z |
| format | Article |
| id | doaj.art-c16bea6043274a5385a252d8be63a3c4 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-11T18:05:40Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-c16bea6043274a5385a252d8be63a3c42022-12-22T04:10:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-09-011210.3389/fonc.2022.985613985613Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysisYue Li0Jiahuan Xu1Pengchen Bao2Zhijing Wei3Lei Pan4Jiawei Zhou5Wei Wang6Department of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, ChinaChina Medical University, Shenyang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, ChinaDepartment of Respiratory and Critical Care Medicine, The First Hospital of China Medical University, Shenyang, ChinaBackgroundProline metabolism is closely related to the occurrence and development of cancer. Δ1-Pyrroline-5-carboxylate reductase (PYCR) is the last enzyme in proline biosynthesis. As one of the enzyme types, PYCR1 takes part in the whole process of the growth, invasion, and drug resistance of cancer cells. This study investigated PYCR1 expressions in cancers together with their relationship to clinical prognosis.MethodsA thorough database search was performed in PubMed, EMBASE, and Cochrane Library. RevMan5.3 software was used for the statistical analysis.ResultsEight articles were selected, and 728 cancer patients were enrolled. The cancer types include lung, stomach, pancreatic ductal adenocarcinoma, hepatocellular carcinoma, and renal cell carcinoma. The meta-analysis results showed that the expression of PYCR1 was higher in the clinical stage III–IV group than that in the clinical stage I–II group (OR = 1.67, 95%CI: 1.03–2.71), higher in the lymph node metastasis group than in the non-lymph node metastasis group (OR = 1.57, 95%CI: 1.06–2.33), and higher in the distant metastasis group than in the non-distant metastasis group (OR = 3.46, 95%CI: 1.64–7.29). However, there was no statistical difference in PYCR1 expression between different tumor sizes (OR = 1.50, 95%CI: 0.89–2.53) and degrees of differentiation (OR = 0.82, 95%CI: 0.54–1.24).ConclusionPYCR1 had a high expression in various cancers and was associated with cancer volume and metastasis. The higher the PYCR1 expression was, the poorer the cancer prognosis was. The molecular events and biological processes mediated by PYCR1 might be the underlying mechanisms of metastasis.https://www.frontiersin.org/articles/10.3389/fonc.2022.985613/fullPYCR1cancermeta-analysisprognosissurvival |
| spellingShingle | Yue Li Jiahuan Xu Pengchen Bao Zhijing Wei Lei Pan Jiawei Zhou Wei Wang Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis Frontiers in Oncology PYCR1 cancer meta-analysis prognosis survival |
| title | Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis |
| title_full | Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis |
| title_fullStr | Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis |
| title_full_unstemmed | Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis |
| title_short | Survival and clinicopathological significance of PYCR1 expression in cancer: A meta-analysis |
| title_sort | survival and clinicopathological significance of pycr1 expression in cancer a meta analysis |
| topic | PYCR1 cancer meta-analysis prognosis survival |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.985613/full |
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